Sevelamer: Non-Absorbed Phosphate Binder
Sevelamer is a cross-linked polymeric amine (poly(allylamine hydrochloride) or carbonate salt) that acts as a non-absorbed, non-calcium, non-metal phosphate binder in the gastrointestinal tract. It binds dietary phosphate through ionic and hydrogen bonding, forming an insoluble complex that is excreted in the feces, reducing serum phosphorus levels without adding calcium load.
Product Profile
| CAS Number | 52757-95-6 |
|---|---|
| Appearance | White to off-white powder |
| Therapeutic Category | Phosphate binder |
| Storage | Room temperature, protect from moisture |
Applications
Sevelamer is indicated for the control of hyperphosphatemia in patients with chronic kidney disease (CKD) on dialysis. Available as sevelamer hydrochloride or sevelamer carbonate — the carbonate form was developed to avoid the metabolic acidosis risk associated with the hydrochloride salt. Typical dosing is 800–1600 mg three times daily with meals, adjusted based on serum phosphorus levels. Sevelamer also provides ancillary benefits including LDL cholesterol reduction and decreased uric acid levels. It is formulated as tablets and powder for oral suspension.
Why Source from TCS
TCS supplies sevelamer to pharmaceutical companies across Europe and globally. Flexible order quantities from development samples to commercial volumes. Contact us with your target market and project requirements for a tailored quotation.
FAQ
What information should be included in an inquiry for Sevelamer 52757-95-6?
A useful inquiry normally includes the product name, target application, estimated quantity, destination market, and any specific documentation or packaging requests.
How is Sevelamer 52757-95-6 usually evaluated for sourcing?
This product is positioned for pharmaceutical sourcing discussions covering development, pilot, or commercial demand, subject to the buyer confirming application scope, market, and document requirements.
What documentation and commercial points are commonly reviewed before buying Sevelamer 52757-95-6?
For pharmaceutical API procurement, buyers commonly align on specification review, target market, batch or annual demand, packaging expectations, and the documentation package needed for the project.
Request a Quote
If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.