TCS Industries Limited (China-sourced API supplier) supplies Trilostane API — API CAS 13647-35-3 for pharmaceutical B2B procurement — COA, MSDS, and technical documentation available on request.
> Overview
| Product Name | Trilostane API |
|---|---|
| Structural Formula |  |
| CAS Number | 13647-35-3 |
| Molecular Formula | C20H27NO3 |
| Molecular Weight | 329.44 g/mol |
| InChIKey | KVJXBPDAXMEYOA-CXANFOAXSA-N |
| SMILES | Available on request where applicable |
| Appearance | White to off-white crystalline powder |
| Purity / Grade | ≥98% (HPLC) |
| Storage | 2–8°C, protected from light, dry conditions |
Trilostane (CAS 13647-35-3) is a competitive inhibitor of 3β-hydroxysteroid dehydrogenase (3β-HSD) with the formula C₂₀H₂₇NO₃ (MW 329.43). It blocks the conversion of pregnenolone to progesterone and dehydroepiandrosterone (DHEA) to androstenedione, thereby reducing cortisol, aldosterone, and sex steroid synthesis. Trilostane is used for canine hyperadrenocorticism (Cushing disease) and is the primary medical treatment for pituitary-dependent and adrenal-dependent forms.
TCS Industries Limited, a Hong Kong-based trading and sourcing company, supplies Trilostane API in veterinary pharmaceutical grade for global procurement programs.
> Applications
Canine hyperadrenocorticism (Cushing disease)
Trilostane 1–2 mg/kg orally once or twice daily (starting dose ~2 mg/kg once daily with food) is the standard medical treatment for both pituitary-dependent (PDH, ~85% of cases) and adrenal-dependent hyperadrenocorticism in dogs. It suppresses adrenal steroidogenesis, reducing cortisol production. ACTH stimulation testing at 4-hour post-pill is used for dose monitoring. Ramsey et al. (J Small Anim Pract, 2008, 49:2–11) evaluated the safety and efficacy of trilostane for hyperadrenocorticism in dogs and established the dosing and monitoring protocols used as the standard of care.
Dose titration and monitoring
Individual dose titration is critical — response to trilostane varies widely between patients. Post-ACTH cortisol target is 1.5–5.0 μg/dL (40–140 nmol/L) at 4–6 hours post-pill. Doses are adjusted in 0.5–1 mg/kg increments every 4–6 weeks. Twice-daily dosing may provide better cortisol control in some patients.
> Sourcing & Supply
TCS Industries Limited supports development, qualification and commercial purchasing discussions for Trilostane API with buyers in Australia, New Zealand, Canada and South Korea.
- Evaluation and commercial quantities: 100 g samples for formulation development; 1 kg and 5 kg for production. Veterinary pharmaceutical-grade crystalline powder. For veterinary use only.
- Pallet quantities and production campaigns: repeat supply is coordinated against packaging, lead time, annual demand and destination-market import requirements.
> Quality & Documentation
Key specification parameters include assay (≥98.0%), related substances, specific optical rotation, loss on drying, residue on ignition, heavy metals, residual solvents, and microbial limits. White to off-white crystalline powder. Practically insoluble in water, soluble in chloroform and ethanol. Melting point 269–273 °C. Identity by HPLC, IR, and specific optical rotation. Meets in-house veterinary pharmaceutical specifications. COA and MSDS are standard.
> Packaging
Trilostane is a white to off-white crystalline powder. Standard packaging includes double PE-lined foil bags in fibre drums (100 g, 500 g, 1 kg, or 5 kg). Store at controlled room temperature (15–25 °C). Protect from light and moisture. Shelf life is typically 36 months. Labels and documents are checked before dispatch.
> Pricing & MOQ
Pricing is quoted by specification, packaging and destination. Common commercial discussions use 25 kg bag/drum formats, pallet quantities and production-campaign planning; smaller samples may be reviewed for qualified formulation teams.
> Regulatory & Compounding Context
Trilostane is approved for veterinary use (Vetoryl, Dechra) — FDA-CVM approved in 2008 for canine hyperadrenocorticism. EMA-authorized for veterinary use. Trilostane was previously approved for human use (Modrenal) in the UK for breast cancer and Cushing syndrome but was withdrawn from the human market. Available as Vetoryl capsules (5, 10, 30, 60, 120 mg). Generic veterinary trilostane products available in some markets.
> Alias Index
- INN: Trilostane
- CAS Number: 13647-35-3
- Formula: C₂₀H₂₇NO₃ (MW 329.43)
- Brand names: Vetoryl (Dechra, veterinary), Modrenal (withdrawn human product)
- ATCvet code: QH02CA01
- Target: 3β-hydroxysteroid dehydrogenase (3β-HSD) inhibitor
- Commercial request terms: trilostane API, Vetoryl generic, Cushing disease treatment, adrenal steroidogenesis inhibitor, TCS Industries Limited
> FAQ
How does ACTH stimulation monitoring work?
ACTH stimulation test is performed 4–6 hours after trilostane administration. Synthetic ACTH (cosyntropin 5 μg/kg IV) is given, and cortisol is measured before and 1 hour after ACTH injection. Target post-ACTH cortisol: 1.5–5.0 μg/dL (40–140 nmol/L). Below 1.5 μg/dL indicates overdosing and risk of Addisonian crisis. Testing is done at 10 days, 4 weeks, 12 weeks, then every 3 months.
What documents are available for Trilostane API orders?
COA and MSDS are standard for commercial discussions. COO, packing list, invoice and other import-support documents can be arranged according to order scope.
Do you supply Trilostane API to Australia and Canada?
Yes. We support B2B buyers in Australia, New Zealand, Canada and South Korea, subject to route and document review.
Do you supply New Zealand and South Korea?
Yes. We review Australia, New Zealand, Canada and South Korea for project supply, import documents, packaging and logistics planning before quotation.
What is the risk of Addisonian crisis?
Trilostane overdose can cause iatrogenic hypoadrenocorticism (Addisonian crisis): weakness, collapse, vomiting, diarrhea, bradycardia, and hyperkalemia. This is a medical emergency requiring IV fluids, dexamethasone, and discontinuation of trilostane. Incidence is ~2–3% with proper monitoring. Trilostane effect is reversible (unlike mitotane, which causes permanent adrenocortical destruction).
Why is Trilostane preferred over Mitotane?
Trilostane reversibly inhibits steroid synthesis (competitive enzyme inhibition), while mitotane (Lysodren) causes progressive adrenocortical necrosis (permanent destruction). Trilostane has a wider safety margin, is easier to dose-titrate, and has fewer severe adverse effects. Mitotane is reserved for trilostane-refractory cases or adrenal tumors. Trilostane has largely replaced mitotane as the first-line medical treatment.
Can you arrange samples before commercial purchasing?
Samples or evaluation quantities may be reviewed for qualified buyers after target specification, application and destination-market requirements are clarified.
How is Trilostane API packaged for export?
Packaging is confirmed by quantity and material properties. Typical options include foil bags, HDPE containers, fibre drums, 25 kg bags or palletized export packaging.
Can buyer-defined specifications be reviewed?
Yes. Send the specification, methods, impurity limits and required documents. TCS can review feasibility before confirming quotation and lead time.
What payment terms are normally used?
Standard payment is 100% T/T before dispatch unless a different arrangement has been approved for an established commercial account.
What lead time should buyers expect?
Lead time depends on stock, batch size, document scope and destination. Available stock can move faster; made-to-order or pallet programs require longer planning.
Is regulatory documentation available?
Yes. TCS sources trilostane from qualified manufacturers. Veterinary pharmaceutical-grade material meeting in-house specifications. COA, stability data, and regulatory documentation provided for veterinary generic capsule formulation development.
Last reviewed: June 2026
Evaluation and research orders (≤10 kg) are shipped with COA, MSDS, and certificate of origin. Bulk commercial orders (>10 kg) qualify for volume pricing with a full technical documentation package available on request.
> Request a Quote
If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.