TCS Industries Limited (China-sourced API supplier) supplies Prostaglandin E1 — API CAS 745-65-3 for pharmaceutical B2B procurement — COA, MSDS, and technical documentation available on request.
> Overview
| Product Name | Prostaglandin E1 |
|---|---|
| Structural Formula |  |
| CAS Number | 745-65-3 |
| Molecular Formula | C₂₀H₃₄O₅ |
| Molecular Weight | 354.5 g/mol |
| InChIKey | GMVPRGQOIOIIMI-DWKJAMRDSA-N |
| SMILES | Available on request where applicable |
| Appearance | White to off-white crystalline powder |
| Purity / Grade | By agreed specification and batch COA |
| Storage | -20°C, protect from light, store under inert gas |
Prostaglandin E1 (CAS 745-65-3, alprostadil, PGE₁) is a naturally occurring prostaglandin with the formula C₂₀H₃₄O₅ (MW 354.48). PGE₁ relaxes smooth muscle, causes vasodilation, and inhibits platelet aggregation. It is used for maintaining patent ductus arteriosus in neonates, erectile dysfunction (intracavernosal injection), and peripheral vascular disease.
TCS Industries Limited, a Hong Kong-based trading and sourcing company, supplies Prostaglandin E1 (Alprostadil) API in pharmaceutical grade for global procurement programs.
> Applications
Neonatal ductus arteriosus maintenance
Alprostadil IV infusion 0.05–0.1 μg/kg/min maintains ductal patency in neonates with ductus-dependent congenital heart defects (transposition of great arteries, pulmonary atresia, critical coarctation) pending surgical repair. PGE₁ prevents the normal postnatal ductal closure by relaxing ductal smooth muscle. Olley et al. (Circulation, 1976, 53:728–731) first demonstrated the life-saving effectiveness of PGE₁ infusion in maintaining patent ductus arteriosus in critically ill neonates with ductus-dependent congenital heart disease.
Erectile dysfunction and peripheral vascular disease
Alprostadil intracavernosal injection (Caverject, 5–40 μg) or intraurethral pellet (MUSE, 125–1000 μg) is used for erectile dysfunction. IV alprostadil is used in Europe and Japan for chronic peripheral arterial occlusive disease (Buerger disease, intermittent claudication) and diabetic neuropathy.
> Sourcing & Supply
TCS Industries Limited supports development, qualification and commercial purchasing discussions for Prostaglandin E1 with buyers in Australia, New Zealand, Canada and South Korea.
- Evaluation and commercial quantities: 1 g samples for analytical qualification; 10 g and 100 g for production. High-potency API — microgram dosing. Cold chain required. DMF reference letters available.
- Pallet quantities and production campaigns: repeat supply is coordinated against packaging, lead time, annual demand and destination-market import requirements.
> Quality & Documentation
Key specification parameters include assay (≥97.0%), related substances (PGA₁, 15-keto-PGE₁), specific optical rotation, water content, residual solvents, heavy metals, and microbial limits. White to off-white crystalline powder. Soluble in ethanol, slightly soluble in water. Thermally and oxidatively sensitive. Identity by HPLC and IR. Meets USP (Alprostadil) and Ph.Eur. (Alprostadilum). COA and MSDS are standard.
> Packaging
Alprostadil (PGE₁) is a white to off-white crystalline powder, sensitive to heat and oxidation. High-potency API. Standard packaging includes sealed amber glass vials or foil bags under nitrogen (1 g, 5 g, or 10 g). Store at -20 °C. Protect from light and moisture. Shelf life is typically 24 months at -20 °C. Labels and documents are checked before dispatch.
> Pricing & MOQ
Pricing is quoted by specification, packaging and destination. Common commercial discussions use 25 kg bag/drum formats, pallet quantities and production-campaign planning; smaller samples may be reviewed for qualified formulation teams.
> Regulatory & Compounding Context
Alprostadil is monographed in USP and Ph.Eur. FDA-approved for neonatal ductus (Prostin VR, 1981) and erectile dysfunction (Caverject, 1995; MUSE, 1997). EMA-authorized. On the WHO Model List of Essential Medicines (neonatal indication). Generic alprostadil products available. High-potency API. DMF support available.
> Alias Index
- INN: Alprostadil
- CAS Number: 745-65-3
- Formula: C₂₀H₃₄O₅ (MW 354.48)
- Chemical name: Prostaglandin E1 (PGE₁)
- Brand names: Prostin VR (neonatal), Caverject (ED), MUSE (ED)
- ATC code: C01EA01 (vascular), G04BE01 (ED)
- Commercial request terms: alprostadil API, PGE1 pharmaceutical grade, Prostin VR generic, Caverject generic, TCS Industries Limited
> FAQ
Why is PGE1 critical for neonates with heart defects?
In ductus-dependent congenital heart defects, systemic or pulmonary blood flow depends on a patent ductus arteriosus. Without PGE₁, the ductus closes within 24–48 hours after birth, causing fatal hypoxemia. PGE₁ infusion maintains ductal patency until surgical repair can be performed. It is a life-saving emergency medication.
What documents are available for Prostaglandin E1 orders?
COA and MSDS are standard for commercial discussions. COO, packing list, invoice and other import-support documents can be arranged according to order scope.
Do you supply Prostaglandin E1 to Australia and Canada?
Yes. We support B2B buyers in Australia, New Zealand, Canada and South Korea, subject to route and document review.
Do you supply New Zealand and South Korea?
Yes. We review Australia, New Zealand, Canada and South Korea for project supply, import documents, packaging and logistics planning before quotation.
Why is cold storage required?
Alprostadil is chemically unstable — it undergoes oxidation and dehydration at elevated temperatures. The cyclopentanone ring and hydroxyl groups are susceptible to degradation. Storage at -20 °C preserves stability. Reconstituted solutions must be used within hours. Cold chain logistics are required for API shipment.
What formulations are available for erectile dysfunction?
Caverject: lyophilized alprostadil for intracavernosal injection (5–40 μg per injection). MUSE: intraurethral pellet inserted via applicator (125–1000 μg). Topical cream (Vitaros, 300 μg) is approved in some markets. Each route has different onset, efficacy, and local side effect profiles.
Can you arrange samples before commercial purchasing?
Samples or evaluation quantities may be reviewed for qualified buyers after target specification, application and destination-market requirements are clarified.
How is Prostaglandin E1 packaged for export?
Packaging is confirmed by quantity and material properties. Typical options include foil bags, HDPE containers, fibre drums, 25 kg bags or palletized export packaging.
Can buyer-defined specifications be reviewed?
Yes. Send the specification, methods, impurity limits and required documents. TCS can review feasibility before confirming quotation and lead time.
What payment terms are normally used?
Standard payment is 100% T/T before dispatch unless a different arrangement has been approved for an established commercial account.
What lead time should buyers expect?
Lead time depends on stock, batch size, document scope and destination. Available stock can move faster; made-to-order or pallet programs require longer planning.
Is a DMF available?
Yes. TCS sources alprostadil from manufacturers who maintain active DMFs with the FDA and equivalent regulatory submissions. High-potency API production with cold chain capability verified. COA, stability data, and DMF reference letters are provided.
Last reviewed: June 2026
Evaluation and research orders (≤10 kg) are shipped with COA, MSDS, and certificate of origin. Bulk commercial orders (>10 kg) qualify for volume pricing with a full technical documentation package available on request.
> Request a Quote
If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.