Prostaglandin E1 (Alprostadil): Vasodilatory Prostanoid
Prostaglandin E1 (PGE1), also known as alprostadil, is a naturally occurring prostaglandin with potent vasodilatory, antiplatelet, and smooth muscle-relaxing properties. It acts on specific EP receptors, increasing intracellular cAMP in vascular smooth muscle cells, leading to vasodilation. PGE1 also inhibits platelet aggregation and stimulates intestinal smooth muscle contraction.
Product Profile
| CAS Number | 745-65-3 |
|---|---|
| Molecular Formula | C20H34O5 |
| Appearance | White to off-white crystalline powder |
| Therapeutic Category | Vasodilator / prostanoid |
| Storage | -20°C, protect from light, store under inert gas |
Applications
Alprostadil is used intravenously in neonates to maintain patency of the ductus arteriosus in ductal-dependent congenital heart defects prior to corrective surgery. In adults, intravenous PGE1 is used for critical limb ischemia and peripheral arterial disease, particularly in Europe and Japan. Intracavernosal or intraurethral alprostadil is an established treatment for erectile dysfunction. The compound is inherently unstable and requires specialized formulation approaches, including lipid microsphere encapsulation and cyclodextrin complexation, for injectable products.
Why Source from TCS
TCS supplies prostaglandin E1 to pharmaceutical companies across Europe and globally. Flexible order quantities from development samples to commercial volumes. Contact us with your target market and project requirements for a tailored quotation.
FAQ
What information should be included in an inquiry for Prostaglandin E1 745-65-3?
A useful inquiry normally includes the product name, target application, estimated quantity, destination market, and any specific documentation or packaging requests.
How is Prostaglandin E1 745-65-3 usually evaluated for sourcing?
This product is positioned for pharmaceutical sourcing discussions covering development, pilot, or commercial demand, subject to the buyer confirming application scope, market, and document requirements.
What documentation and commercial points are commonly reviewed before buying Prostaglandin E1 745-65-3?
For pharmaceutical API procurement, buyers commonly align on specification review, target market, batch or annual demand, packaging expectations, and the documentation package needed for the project.
Request a Quote
If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.