TCS Industries Limited (China-sourced API supplier) supplies Atenolol — API CAS 29122-68-7 for pharmaceutical B2B procurement — COA, MSDS, and technical documentation available on request.
> Overview
| Product Name | Atenolol |
|---|---|
| Structural Formula |  |
| CAS Number | 29122-68-7 |
| Molecular Formula | C₁₄H₂₂N₂O₃ |
| Molecular Weight | 266.34 g/mol |
| InChIKey | METKIMKYRPQLGS-UHFFFAOYSA-N |
| SMILES | Available on request where applicable |
| Appearance | White crystalline powder |
| Purity / Grade | By agreed specification and batch COA |
| Storage | Room temperature, protect from moisture and light |
Atenolol (CAS 29122-68-7) is a cardioselective beta-1 adrenergic receptor blocker with the formula C₁₄H₂₂N₂O₃ (MW 266.34). It preferentially blocks β₁ receptors in the heart, reducing heart rate, contractility, and blood pressure without significant β₂ bronchospasm. Atenolol is used for hypertension, angina pectoris, and acute myocardial infarction, and is on the WHO Model List of Essential Medicines.
TCS Industries Limited, a Hong Kong-based trading and sourcing company, supplies Atenolol API in pharmaceutical grade for global procurement programs.
> Applications
Hypertension and angina
Atenolol 25–100 mg once daily is used for hypertension and chronic stable angina. Its β₁ selectivity provides cardiac rate and force reduction with less bronchospastic risk than non-selective beta-blockers. It is hydrophilic (does not cross the BBB significantly), reducing CNS side effects. Carlberg et al. (Lancet, 2004, 364:1684–1689) conducted a meta-analysis showing that atenolol-based antihypertensive therapy reduced stroke risk less than other antihypertensives, leading to reassessment of its role as first-line therapy for uncomplicated hypertension.
Acute MI and rate control
IV atenolol (5 mg, repeated once) followed by oral therapy is used in acute myocardial infarction to reduce infarct size and early mortality. It is also used for supraventricular tachycardia rate control and as rate-control therapy in atrial fibrillation.
> Sourcing & Supply
TCS Industries Limited supports development, qualification and commercial purchasing discussions for Atenolol with buyers in Australia, New Zealand, Canada and South Korea.
- Evaluation and commercial quantities: 1 kg samples for formulation development; 5 kg and 25 kg for production. Pharmaceutical (USP/Ph.Eur.) grade. DMF reference letters available.
- Pallet quantities and production campaigns: repeat supply is coordinated against packaging, lead time, annual demand and destination-market import requirements.
> Quality & Documentation
Key specification parameters include assay (≥99.0%), related substances (individual ≤0.1%, total ≤0.5%), loss on drying, residue on ignition, heavy metals, residual solvents, and microbial limits. White crystalline powder. Sparingly soluble in water, soluble in methanol. Melting point 152–155 °C. Identity by HPLC, IR, and melting point. Meets USP (Atenolol), Ph.Eur. (Atenololum), BP, and JP. COA and MSDS are standard.
> Packaging
Atenolol is a white crystalline powder. Standard packaging includes double PE-lined foil bags in fibre drums (1 kg, 5 kg, or 25 kg). Store at controlled room temperature (15–25 °C). Protect from light and moisture. Shelf life is typically 36 months. Labels and documents are checked before dispatch.
> Pricing & MOQ
Pricing is quoted by specification, packaging and destination. Common commercial discussions use 25 kg bag/drum formats, pallet quantities and production-campaign planning; smaller samples may be reviewed for qualified formulation teams.
> Regulatory & Compounding Context
Atenolol is monographed in USP, Ph.Eur. (Atenololum), BP, and JP. FDA-approved in 1981 (Tenormin). On the WHO Model List of Essential Medicines. Off-patent globally with extensive generic availability. Available as tablets (25, 50, 100 mg) and IV injection. DMF support available.
> Alias Index
- INN: Atenolol
- CAS Number: 29122-68-7
- Formula: C₁₄H₂₂N₂O₃ (MW 266.34)
- Brand name: Tenormin (AstraZeneca)
- ATC code: C07AB03
- Pharmacological class: Cardioselective beta-1 blocker
- Commercial request terms: atenolol API, Tenormin generic, beta blocker API, antihypertensive API, TCS Industries Limited
> FAQ
Is Atenolol still recommended as first-line for hypertension?
Current guidelines (ESC/ESH, AHA/ACC) have moved atenolol from first-line to second-line for uncomplicated hypertension based on the Carlberg meta-analysis and ASCOT-BPLA trial. However, atenolol remains first-line for hypertension with concurrent angina, post-MI, tachyarrhythmia, or heart failure with preserved ejection fraction.
What documents are available for Atenolol orders?
COA and MSDS are standard for commercial discussions. COO, packing list, invoice and other import-support documents can be arranged according to order scope.
Do you supply Atenolol to Australia and Canada?
Yes. We support B2B buyers in Australia, New Zealand, Canada and South Korea, subject to route and document review.
Do you supply New Zealand and South Korea?
Yes. We review Australia, New Zealand, Canada and South Korea for project supply, import documents, packaging and logistics planning before quotation.
Why is Atenolol considered hydrophilic?
Atenolol has low lipophilicity (log P ~0.16), limiting BBB penetration. This reduces CNS side effects (insomnia, nightmares, depression) compared to lipophilic beta-blockers (propranolol, metoprolol). However, it also means less CNS beta-blockade benefit where that is therapeutically desired (tremor, anxiety, migraine prophylaxis).
Is renal dose adjustment needed?
Yes. Atenolol is ~50% renally eliminated unchanged. Dose reduction is required in renal impairment: CrCl 15–35 mL/min → max 50 mg/day; CrCl <15 mL/min → max 25 mg/day. Dialysis removes atenolol — give supplemental doses after hemodialysis. This renal elimination distinguishes atenolol from metoprolol (hepatically metabolized).
Can you arrange samples before commercial purchasing?
Samples or evaluation quantities may be reviewed for qualified buyers after target specification, application and destination-market requirements are clarified.
How is Atenolol packaged for export?
Packaging is confirmed by quantity and material properties. Typical options include foil bags, HDPE containers, fibre drums, 25 kg bags or palletized export packaging.
Can buyer-defined specifications be reviewed?
Yes. Send the specification, methods, impurity limits and required documents. TCS can review feasibility before confirming quotation and lead time.
What payment terms are normally used?
Standard payment is 100% T/T before dispatch unless a different arrangement has been approved for an established commercial account.
What lead time should buyers expect?
Lead time depends on stock, batch size, document scope and destination. Available stock can move faster; made-to-order or pallet programs require longer planning.
Is a DMF available?
Yes. TCS sources atenolol from manufacturers who maintain active DMFs. Off-patent with extensive generic availability globally. COA, stability data, and DMF reference letters provided.
Last reviewed: June 2026
Evaluation and research orders (≤10 kg) are shipped with COA, MSDS, and certificate of origin. Bulk commercial orders (>10 kg) qualify for volume pricing with a full technical documentation package available on request.
> Request a Quote
If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.