TCS Industries Limited (China-sourced API supplier) supplies Benazepril — API CAS 86541-75-5 for pharmaceutical B2B procurement — COA, MSDS, and technical documentation available on request.
> Overview
| Product Name | Benazepril |
|---|---|
| Structural Formula |  |
| CAS Number | 86541-75-5 |
| Molecular Formula | C₂₄H₂₈N₂O₅ |
| Molecular Weight | 424.5 g/mol |
| InChIKey | XPCFTKFZXHTYIP-PMACEKPBSA-N |
| SMILES | Available on request where applicable |
| Appearance | White to off-white crystalline powder |
| Purity / Grade | By agreed specification and batch COA |
| Storage | Room temperature, protect from moisture |
Benazepril (CAS 86541-75-5) is an angiotensin-converting enzyme (ACE) inhibitor prodrug with the formula C₂₄H₂₈N₂O₅ (MW 424.49). Benazepril is hydrolyzed in the liver to benazeprilat, the active diacid that inhibits ACE, reducing angiotensin II formation and aldosterone secretion. It is used for hypertension and congestive heart failure.
TCS Industries Limited, a Hong Kong-based trading and sourcing company, supplies Benazepril HCl API in pharmaceutical grade for global procurement programs.
> Applications
Hypertension and cardiovascular protection
Benazepril 10–40 mg once daily lowers blood pressure by inhibiting ACE-mediated conversion of angiotensin I to angiotensin II. This reduces peripheral vascular resistance, aldosterone secretion, and sodium/water retention. It is used as monotherapy or combined with hydrochlorothiazide (Lotensin HCT) or amlodipine (Lotrel). Balfour et al. (Drugs, 1991, 42:511–539) reviewed the pharmacodynamic properties and clinical efficacy of benazepril as an ACE inhibitor for hypertension management with its favorable once-daily dosing profile.
Veterinary use
Benazepril HCl is also widely used in veterinary medicine (Fortekor) for chronic kidney disease and heart failure in dogs and cats. It is one of the few ACE inhibitors with significant hepatic elimination, making it suitable for patients with renal impairment.
> Sourcing & Supply
TCS Industries Limited supports development, qualification and commercial purchasing discussions for Benazepril with buyers in Australia, New Zealand, Canada and South Korea.
- Evaluation and commercial quantities: 500 g samples for formulation development; 5 kg and 25 kg for production. Pharmaceutical (USP) grade. Human and veterinary grades available. DMF reference letters provided.
- Pallet quantities and production campaigns: repeat supply is coordinated against packaging, lead time, annual demand and destination-market import requirements.
> Quality & Documentation
Key specification parameters include assay (≥98.0%), related substances, specific optical rotation, loss on drying, residue on ignition, heavy metals, residual solvents, and microbial limits. White to off-white crystalline powder (as HCl salt). Slightly soluble in water, soluble in methanol. Identity by HPLC and IR. Meets USP (Benazepril Hydrochloride) and Ph.Eur. COA and MSDS are standard.
> Packaging
Benazepril HCl is a white to off-white crystalline powder. Standard packaging includes double PE-lined foil bags in fibre drums (1 kg, 5 kg, or 25 kg). Store at controlled room temperature (15–25 °C). Protect from moisture. Shelf life is typically 36 months. Labels and documents are checked before dispatch.
> Pricing & MOQ
Pricing is quoted by specification, packaging and destination. Common commercial discussions use 25 kg bag/drum formats, pallet quantities and production-campaign planning; smaller samples may be reviewed for qualified formulation teams.
> Regulatory & Compounding Context
Benazepril HCl is monographed in USP. FDA-approved in 1991 (Lotensin). Combination products: Lotensin HCT (with HCTZ) and Lotrel (with amlodipine). Off-patent with multiple generic approvals. Veterinary product (Fortekor) approved in EU and other markets. DMF support available.
> Alias Index
- INN: Benazepril
- CAS Number: 86541-75-5 (base); 86541-74-4 (HCl)
- Formula: C₂₄H₂₈N₂O₅ (MW 424.49)
- Brand names: Lotensin, Lotrel (with amlodipine), Fortekor (veterinary)
- ATC code: C09AA07
- Active metabolite: Benazeprilat (diacid)
- Commercial request terms: benazepril HCl API, Lotensin generic, ACE inhibitor API, Fortekor API, TCS Industries Limited
> FAQ
What makes Benazepril different from other ACE inhibitors?
Benazepril has dual elimination — approximately 50% hepatic and 50% renal excretion. Most ACE inhibitors (enalapril, lisinopril, ramipril) are primarily renally eliminated. This dual pathway means benazepril dose adjustment in renal impairment is less critical. It also has a long duration of action (24 hours) supporting once-daily dosing.
What documents are available for Benazepril orders?
COA and MSDS are standard for commercial discussions. COO, packing list, invoice and other import-support documents can be arranged according to order scope.
Do you supply Benazepril to Australia and Canada?
Yes. We support B2B buyers in Australia, New Zealand, Canada and South Korea, subject to route and document review.
Do you supply New Zealand and South Korea?
Yes. We review Australia, New Zealand, Canada and South Korea for project supply, import documents, packaging and logistics planning before quotation.
Is Benazepril used in veterinary medicine?
Yes. Benazepril (Fortekor, 0.25–0.5 mg/kg once daily) is widely used in dogs for congestive heart failure and in cats for chronic kidney disease. The dual hepatic-renal elimination is advantageous in cats with renal impairment. It is one of the few ACE inhibitors specifically approved and studied for feline chronic kidney disease.
How does Lotrel combine Benazepril and Amlodipine?
Lotrel contains benazepril HCl + amlodipine besylate in a fixed-dose combination tablet. The ACE inhibitor reduces renin-angiotensin activation and the amlodipine-induced ankle edema. The calcium channel blocker adds vasodilation beyond ACE inhibition alone. Available in multiple dose combinations (5/10, 5/20, 5/40, 10/20, 10/40 mg).
Can you arrange samples before commercial purchasing?
Samples or evaluation quantities may be reviewed for qualified buyers after target specification, application and destination-market requirements are clarified.
How is Benazepril packaged for export?
Packaging is confirmed by quantity and material properties. Typical options include foil bags, HDPE containers, fibre drums, 25 kg bags or palletized export packaging.
Can buyer-defined specifications be reviewed?
Yes. Send the specification, methods, impurity limits and required documents. TCS can review feasibility before confirming quotation and lead time.
What payment terms are normally used?
Standard payment is 100% T/T before dispatch unless a different arrangement has been approved for an established commercial account.
What lead time should buyers expect?
Lead time depends on stock, batch size, document scope and destination. Available stock can move faster; made-to-order or pallet programs require longer planning.
Is a DMF available?
Yes. TCS sources benazepril HCl from manufacturers who maintain active DMFs with the FDA. Off-patent with generic competition. COA, stability data, and DMF reference letters are provided.
Last reviewed: June 2026
Evaluation and research orders (≤10 kg) are shipped with COA, MSDS, and certificate of origin. Bulk commercial orders (>10 kg) qualify for volume pricing with a full technical documentation package available on request.
> Request a Quote
If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.