Acetazolamide: Carbonic Anhydrase Inhibitor
Acetazolamide is a sulfonamide derivative that reversibly inhibits carbonic anhydrase, the enzyme catalyzing the hydration of carbon dioxide and the dehydration of carbonic acid. By inhibiting this enzyme in the renal proximal tubule, acetazolamide promotes bicarbonate excretion, producing a mild metabolic acidosis. In the eye, inhibition of carbonic anhydrase in the ciliary body reduces aqueous humor formation, lowering intraocular pressure.
Product Profile
| CAS Number | 59-66-5 |
|---|---|
| Molecular Formula | C4H6N4O3S2 |
| Appearance | White to off-white crystalline powder |
| Therapeutic Category | Carbonic anhydrase inhibitor |
| Storage | Room temperature |
Applications
Acetazolamide is used in the treatment of open-angle glaucoma and secondary glaucoma as an adjunct to other ocular hypotensives. It is a first-line prophylactic for acute mountain sickness (AMS), typically dosed at 125–250 mg twice daily starting 24 hours before ascent. Acetazolamide is also indicated for certain forms of epilepsy (absence seizures) and as a diuretic in edematous conditions associated with congestive heart failure. Extended-release capsules and injectable formulations are available. In neurology, it is used to manage idiopathic intracranial hypertension (pseudotumor cerebri).
Why Source from TCS
TCS supplies acetazolamide to pharmaceutical companies across Europe and globally. Flexible order quantities from development samples to commercial volumes. Contact us with your target market and project requirements for a tailored quotation.
FAQ
What information should be included in an inquiry for Acetazolamide 59-66-5?
A useful inquiry normally includes the product name, target application, estimated quantity, destination market, and any specific documentation or packaging requests.
How is Acetazolamide 59-66-5 usually evaluated for sourcing?
This product is positioned for pharmaceutical sourcing discussions covering development, pilot, or commercial demand, subject to the buyer confirming application scope, market, and document requirements.
What documentation and commercial points are commonly reviewed before buying Acetazolamide 59-66-5?
For pharmaceutical API procurement, buyers commonly align on specification review, target market, batch or annual demand, packaging expectations, and the documentation package needed for the project.
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