TCS Industries Limited (China-sourced API supplier) supplies Acetazolamide — API CAS 59-66-5 for pharmaceutical B2B procurement — COA, MSDS, and technical documentation available on request.
> Overview
| Product Name | Acetazolamide |
|---|---|
| Structural Formula |  |
| CAS Number | 59-66-5 |
| Molecular Formula | C₄H₆N₄O₃S₂ |
| Molecular Weight | 222.3 g/mol |
| InChIKey | BZKPWHYZMXOIDC-UHFFFAOYSA-N |
| SMILES | Available on request where applicable |
| Appearance | White to slightly yellowish crystalline powder |
| Purity / Grade | By agreed specification and batch COA |
| Storage | Room temperature |
Acetazolamide (CAS 59-66-5) is a carbonic anhydrase inhibitor with the formula C₄H₆N₄O₃S₂ (MW 222.25). It inhibits carbonic anhydrase (CA) isoenzymes, particularly CA-II and CA-IV, reducing bicarbonate reabsorption in the renal proximal tubule and aqueous humor production in the ciliary body. Acetazolamide is used for glaucoma, altitude sickness, epilepsy, and idiopathic intracranial hypertension.
TCS Industries Limited, a Hong Kong-based trading and sourcing company, supplies Acetazolamide API in pharmaceutical grade for global procurement programs.
> Applications
Glaucoma and altitude sickness
Acetazolamide 250 mg 2–4 times daily reduces aqueous humor production, lowering IOP in glaucoma. For altitude sickness prevention, 125–250 mg twice daily starting 1 day before ascent accelerates acclimatization by inducing metabolic acidosis and stimulating ventilation. Leaf et al. (BMJ, 2007, 335:1159) published guidelines on the prevention and treatment of acute mountain sickness including the role of acetazolamide in acclimatization protocols for high-altitude travelers.
Epilepsy and intracranial hypertension
Acetazolamide is used as adjunctive therapy for absence seizures, catamenial epilepsy, and as a first-line medical treatment for idiopathic intracranial hypertension (IIH/pseudotumor cerebri). It reduces CSF production through choroid plexus CA inhibition.
> Sourcing & Supply
TCS Industries Limited supports development, qualification and commercial purchasing discussions for Acetazolamide with buyers in Australia, New Zealand, Canada and South Korea.
- Evaluation and commercial quantities: 500 g samples for formulation development; 5 kg and 25 kg for production. Pharmaceutical (USP/Ph.Eur.) grade. DMF reference letters available.
- Pallet quantities and production campaigns: repeat supply is coordinated against packaging, lead time, annual demand and destination-market import requirements.
> Quality & Documentation
Key specification parameters include assay (≥99.0%), related substances, loss on drying, residue on ignition, heavy metals, residual solvents, and microbial limits. White to slightly yellowish crystalline powder. Slightly soluble in water, soluble in DMSO and dilute NaOH. Melting point 258–261 °C. Identity by HPLC, IR, and melting point. Meets USP (Acetazolamide), Ph.Eur. (Acetazolamidum), and BP. COA and MSDS are standard.
> Packaging
Acetazolamide is a white to slightly yellowish crystalline powder. Standard packaging includes double PE-lined foil bags in fibre drums (1 kg, 5 kg, or 25 kg). Store at controlled room temperature (15–25 °C). Protect from light and moisture. Shelf life is typically 36 months. Labels and documents are checked before dispatch.
> Pricing & MOQ
Pricing is quoted by specification, packaging and destination. Common commercial discussions use 25 kg bag/drum formats, pallet quantities and production-campaign planning; smaller samples may be reviewed for qualified formulation teams.
> Regulatory & Compounding Context
Acetazolamide is monographed in USP, Ph.Eur. (Acetazolamidum), BP, and JP. FDA-approved in 1953 (Diamox). On the WHO Model List of Essential Medicines. Off-patent with multiple generic approvals. Available as tablets, sustained-release capsules, and IV injection. DMF support available.
> Alias Index
- INN: Acetazolamide
- CAS Number: 59-66-5
- Formula: C₄H₆N₄O₃S₂ (MW 222.25)
- Brand name: Diamox
- ATC code: S01EC01
- Pharmacological class: Carbonic anhydrase inhibitor
- Commercial request terms: acetazolamide API, Diamox generic, carbonic anhydrase inhibitor, altitude sickness drug, TCS Industries Limited
> FAQ
How does Acetazolamide prevent altitude sickness?
Acetazolamide inhibits renal CA-II, causing bicarbonate diuresis and metabolic acidosis. This acidosis stimulates ventilation (respiratory compensation), increasing blood oxygen saturation at altitude. It accelerates the natural acclimatization process by 1–2 days. It is most effective when started 24 hours before ascent to >2500 meters.
What documents are available for Acetazolamide orders?
COA and MSDS are standard for commercial discussions. COO, packing list, invoice and other import-support documents can be arranged according to order scope.
Do you supply Acetazolamide to Australia and Canada?
Yes. We support B2B buyers in Australia, New Zealand, Canada and South Korea, subject to route and document review.
Do you supply New Zealand and South Korea?
Yes. We review Australia, New Zealand, Canada and South Korea for project supply, import documents, packaging and logistics planning before quotation.
Why do patients experience tingling with Acetazolamide?
Paresthesias (tingling in fingers, toes, lips) occur in ~50% of patients and are caused by CA inhibition in peripheral nerves and altered electrolyte balance (metabolic acidosis, potassium loss). This side effect is dose-dependent and usually tolerable. It serves as a marker of pharmacological activity.
Is Acetazolamide a sulfonamide?
Yes. Acetazolamide contains a sulfonamide group and is contraindicated in patients with documented sulfonamide allergy. However, the cross-reactivity risk between sulfonamide antibiotics and non-antibiotic sulfonamides (like acetazolamide) is debated. Clinical judgment is required for patients with sulfonamide hypersensitivity history.
Can you arrange samples before commercial purchasing?
Samples or evaluation quantities may be reviewed for qualified buyers after target specification, application and destination-market requirements are clarified.
How is Acetazolamide packaged for export?
Packaging is confirmed by quantity and material properties. Typical options include foil bags, HDPE containers, fibre drums, 25 kg bags or palletized export packaging.
Can buyer-defined specifications be reviewed?
Yes. Send the specification, methods, impurity limits and required documents. TCS can review feasibility before confirming quotation and lead time.
What payment terms are normally used?
Standard payment is 100% T/T before dispatch unless a different arrangement has been approved for an established commercial account.
What lead time should buyers expect?
Lead time depends on stock, batch size, document scope and destination. Available stock can move faster; made-to-order or pallet programs require longer planning.
Is a DMF available?
Yes. TCS sources acetazolamide from manufacturers who maintain active DMFs. Off-patent with extensive generic availability. COA, stability data, and DMF reference letters are provided for generic dossier support.
Last reviewed: June 2026
Evaluation and research orders (≤10 kg) are shipped with COA, MSDS, and certificate of origin. Bulk commercial orders (>10 kg) qualify for volume pricing with a full technical documentation package available on request.
> Request a Quote
If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.