Clarithromycin: Semisynthetic Macrolide Antibiotic
Clarithromycin is a semisynthetic 14-membered ring macrolide derived from erythromycin A by methylation of the 6-hydroxyl group. This structural modification confers acid stability and improved oral bioavailability compared to erythromycin. Clarithromycin inhibits bacterial protein synthesis by binding to the 23S rRNA component of the 50S ribosomal subunit. Its active 14-hydroxy metabolite contributes additional antibacterial activity, particularly against Haemophilus influenzae.
Product Profile
| CAS Number | 81103-11-9 |
|---|---|
| Molecular Formula | C38H69NO13 |
| Appearance | White to off-white crystalline powder |
| Therapeutic Category | Macrolide antibiotic |
| Storage | Room temperature, protect from light |
Applications
Clarithromycin is indicated for upper and lower respiratory tract infections (pharyngitis, sinusitis, community-acquired pneumonia, acute exacerbations of chronic bronchitis), skin and soft tissue infections, and disseminated Mycobacterium avium complex (MAC) infection in immunocompromised patients. It is a core component of Helicobacter pylori eradication regimens in combination with a PPI and amoxicillin or metronidazole. Available as immediate-release tablets (250 mg, 500 mg), extended-release tablets, and oral suspension. Standard adult dosing is 250–500 mg twice daily for 7–14 days.
Why Source from TCS
TCS supplies clarithromycin to pharmaceutical companies across Europe and globally. Flexible order quantities from development samples to commercial volumes. Contact us with your target market and project requirements for a tailored quotation.
FAQ
What information should be included in an inquiry for Clarithromycin 81103-11-9?
A useful inquiry normally includes the product name, target application, estimated quantity, destination market, and any specific documentation or packaging requests.
How is Clarithromycin 81103-11-9 usually evaluated for sourcing?
This product is positioned for pharmaceutical sourcing discussions covering development, pilot, or commercial demand, subject to the buyer confirming application scope, market, and document requirements.
What documentation and commercial points are commonly reviewed before buying Clarithromycin 81103-11-9?
For pharmaceutical API procurement, buyers commonly align on specification review, target market, batch or annual demand, packaging expectations, and the documentation package needed for the project.
Request a Quote
If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.