Cisapride: Serotonin 5-HT4 Receptor Agonist Prokinetic
Cisapride is a substituted benzamide that acts as a serotonin 5-HT4 receptor agonist, stimulating acetylcholine release from the myenteric plexus. This enhances coordinated motility throughout the gastrointestinal tract — esophageal peristalsis, gastric emptying, and intestinal transit. Cisapride was withdrawn from most human markets due to cardiac arrhythmia risk (QT prolongation) but remains in active veterinary use.
Product Profile
| CAS Number | 81098-60-4 |
|---|---|
| Molecular Formula | C23H29ClFNO4 |
| Appearance | White to off-white powder |
| Therapeutic Category | Gastroprokinetic agent |
| Storage | Room temperature, protect from moisture |
Applications
In veterinary medicine, cisapride is widely used in cats for megacolon and chronic constipation, where it is often the prokinetic of choice. It is also used in dogs for gastroesophageal reflux and delayed gastric emptying. Veterinary doses in cats are typically 2.5–5 mg per cat, two to three times daily. Compounding pharmacies prepare cisapride into oral suspensions and capsules for veterinary dispensing. Although human use has been restricted, cisapride remains available through limited-access programs in some countries for patients who have failed other therapies.
Why Source from TCS
TCS supplies cisapride to veterinary pharmaceutical companies and compounding pharmacies across Europe and globally. Flexible order quantities from development samples to commercial volumes. Contact us with your project requirements for a tailored quotation.
FAQ
What information should be included in an inquiry for Cisapride 81098-60-4?
A useful inquiry normally includes the product name, target application, estimated quantity, destination market, and any specific documentation or packaging requests.
How is Cisapride 81098-60-4 usually evaluated for sourcing?
This product is positioned for pharmaceutical sourcing discussions covering development, pilot, or commercial demand, subject to the buyer confirming application scope, market, and document requirements.
What documentation and commercial points are commonly reviewed before buying Cisapride 81098-60-4?
For pharmaceutical API procurement, buyers commonly align on specification review, target market, batch or annual demand, packaging expectations, and the documentation package needed for the project.
Request a Quote
If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.