TCS Industries Limited (China-sourced API supplier) supplies Cisapride — API CAS 81098-60-4 for pharmaceutical B2B procurement — COA, MSDS, and technical documentation available on request.
> Overview
| Product Name | Cisapride |
|---|---|
| Structural Formula |  |
| CAS Number | 81098-60-4 |
| Molecular Formula | C₂₃H₂₉ClFNO₄ |
| Molecular Weight | 465.95 g/mol (monohydrate); 437.94 g/mol (anhydrous) |
| InChIKey | DCSUBABJRXZOMT-IRLDBZIGSA-N |
| SMILES | Available on request where applicable |
| Appearance | White to off-white powder |
| Purity / Grade | By agreed specification and batch COA |
| Storage | Room temperature, protect from moisture |
Cisapride (CAS 81098-60-4) is a serotonin 5-HT₄ receptor agonist and prokinetic agent with the formula C₂₃H₂₉ClFN₃O₄ (MW 465.95). It stimulates gastrointestinal motility by enhancing acetylcholine release from the myenteric plexus. Cisapride was withdrawn from the US market in 2000 due to cardiac arrhythmia risk but remains available in some markets and in veterinary medicine.
TCS Industries Limited, a Hong Kong-based trading and sourcing company, supplies Cisapride API in pharmaceutical grade for global procurement programs.
> Applications
Gastrointestinal motility disorders
Cisapride 5–20 mg three to four times daily was used for gastroesophageal reflux disease, gastroparesis, and functional dyspepsia. It stimulates coordinated gastric, small intestinal, and colonic motility through 5-HT₄ receptor-mediated acetylcholine release. Wiseman et al. (Drugs, 1994, 47:116–152) provided a detailed review of the pharmacological properties and therapeutic efficacy of cisapride as a gastrointestinal prokinetic agent.
Veterinary applications
Cisapride is used in veterinary medicine for feline megacolon, canine gastroparesis, and other GI motility disorders. It is one of the few prokinetics with significant colonic prokinetic activity. Veterinary compounding pharmacies are a primary supply channel in markets where it is withdrawn from human use.
> Sourcing & Supply
TCS Industries Limited supports development, qualification and commercial purchasing discussions for Cisapride with buyers in Australia, New Zealand, Canada and South Korea.
- Evaluation and commercial quantities: 100 g samples for formulation development; 1 kg and 5 kg for production. Pharmaceutical-grade crystalline powder. Human and veterinary grades available.
- Pallet quantities and production campaigns: repeat supply is coordinated against packaging, lead time, annual demand and destination-market import requirements.
> Quality & Documentation
Key specification parameters include assay (≥99.0%), related substances, loss on drying, residue on ignition, heavy metals, residual solvents, and microbial limits. White to slightly beige crystalline powder. Practically insoluble in water, soluble in methanol and DMSO. Identity by HPLC and IR. Meets in-house pharmaceutical specifications. COA and MSDS are standard.
> Packaging
Cisapride is a white to slightly beige crystalline powder. Standard packaging includes double PE-lined foil bags in fibre drums (100 g, 500 g, 1 kg, or 5 kg). Store at controlled room temperature (15–25 °C). Protect from light. Shelf life is typically 36 months. Labels and documents are checked before dispatch.
> Pricing & MOQ
Pricing is quoted by specification, packaging and destination. Common commercial discussions use 25 kg bag/drum formats, pallet quantities and production-campaign planning; smaller samples may be reviewed for qualified formulation teams.
> Regulatory & Compounding Context
Cisapride was withdrawn from the US market in 2000 (Propulsid, Janssen) and restricted in other markets due to QT prolongation and torsades de pointes risk when combined with CYP3A4 inhibitors. It remains available in limited-access programs and in some markets. Widely used in veterinary medicine where cardiac monitoring is not standard. Regulatory status varies by jurisdiction.
> Alias Index
- INN: Cisapride
- CAS Number: 81098-60-4
- Formula: C₂₃H₂₉ClFN₃O₄ (MW 465.95)
- Brand name: Propulsid (Janssen, withdrawn US)
- ATC code: A03FA02
- Pharmacological class: 5-HT₄ receptor agonist, prokinetic
- Commercial request terms: cisapride API, Propulsid generic, prokinetic API, veterinary cisapride, GI motility agent, TCS Industries Limited
> FAQ
Why was Cisapride withdrawn from the US market?
Cisapride blocks cardiac hERG potassium channels at therapeutic concentrations, prolonging the QT interval. When combined with CYP3A4 inhibitors (ketoconazole, erythromycin, grapefruit juice) that raise cisapride plasma levels, the QT prolongation risk increases markedly. Post-marketing reports of 341 cases of cardiac arrhythmia (including 80 deaths) led to the 2000 withdrawal.
What documents are available for Cisapride orders?
COA and MSDS are standard for commercial discussions. COO, packing list, invoice and other import-support documents can be arranged according to order scope.
Do you supply Cisapride to Australia and Canada?
Yes. We support B2B buyers in Australia, New Zealand, Canada and South Korea, subject to route and document review.
Do you supply New Zealand and South Korea?
Yes. We review Australia, New Zealand, Canada and South Korea for project supply, import documents, packaging and logistics planning before quotation.
Is Cisapride still available anywhere?
Cisapride remains available in limited-access programs in the US (via manufacturer protocol), in some countries that did not withdraw it, and in veterinary medicine. In many markets, prucalopride (a selective 5-HT₄ agonist without hERG activity) has replaced it. Veterinary compounding pharmacies supply cisapride for animal patients.
How does Cisapride work on the gut?
Cisapride activates 5-HT₄ receptors on myenteric neurons, enhancing acetylcholine release and stimulating coordinated GI motility. Unlike metoclopramide (dopamine antagonist with extrapyramidal effects), cisapride works selectively through the serotonergic pathway. It has prokinetic activity throughout the GI tract — stomach, small intestine, and colon.
Can you arrange samples before commercial purchasing?
Samples or evaluation quantities may be reviewed for qualified buyers after target specification, application and destination-market requirements are clarified.
How is Cisapride packaged for export?
Packaging is confirmed by quantity and material properties. Typical options include foil bags, HDPE containers, fibre drums, 25 kg bags or palletized export packaging.
Can buyer-defined specifications be reviewed?
Yes. Send the specification, methods, impurity limits and required documents. TCS can review feasibility before confirming quotation and lead time.
What payment terms are normally used?
Standard payment is 100% T/T before dispatch unless a different arrangement has been approved for an established commercial account.
What lead time should buyers expect?
Lead time depends on stock, batch size, document scope and destination. Available stock can move faster; made-to-order or pallet programs require longer planning.
Is a DMF available?
TCS sources cisapride from qualified manufacturers. Regulatory documentation varies by jurisdiction and intended use (human, veterinary, or limited-access program). COA and stability data are provided. Buyers should confirm regulatory status in their target market.
Last reviewed: June 2026
Evaluation and research orders (≤10 kg) are shipped with COA, MSDS, and certificate of origin. Bulk commercial orders (>10 kg) qualify for volume pricing with a full technical documentation package available on request.
> Request a Quote
If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.