Mitomycin C: Antitumor Antibiotic Alkylating Agent
Mitomycin C is a natural product isolated from Streptomyces caespitosus that functions as a bioreductive alkylating agent. Upon intracellular reduction, it forms crosslinks between complementary DNA strands, primarily at guanine-guanine sequences, inhibiting DNA synthesis. Its activation under hypoxic conditions makes it particularly effective against poorly vascularized solid tumors.
Product Profile
| CAS Number | 50-07-7 |
|---|---|
| Molecular Formula | C15H18N4O5 |
| Appearance | Blue-violet crystalline powder |
| Therapeutic Category | Antineoplastic / Alkylating Agent |
| Storage | Store at controlled room temperature, protect from light |
Applications
Mitomycin C is administered intravenously for the treatment of gastric adenocarcinoma, pancreatic cancer, and bladder cancer (intravesical instillation for superficial transitional cell carcinoma). Intravesical mitomycin C after transurethral resection of bladder tumors reduces recurrence rates. In ophthalmology, topical mitomycin C is applied during trabeculectomy and pterygium surgery to modulate wound healing and prevent fibrosis. It is also used as an adjunct in laryngeal and airway surgery to prevent stenosis. The compound requires reconstitution before use and is vesicant, requiring careful intravenous administration.
Why Source from TCS
TCS supplies mitomycin C to pharmaceutical companies across Europe and globally. Flexible order quantities from development samples to commercial volumes. Contact us with your target market and project requirements for a tailored quotation.
FAQ
What information should be included in an inquiry for Mitomycin C 50-07-7?
A useful inquiry normally includes the product name, target application, estimated quantity, destination market, and any specific documentation or packaging requests.
How is Mitomycin C 50-07-7 usually evaluated for sourcing?
This product is positioned for pharmaceutical sourcing discussions covering development, pilot, or commercial demand, subject to the buyer confirming application scope, market, and document requirements.
What documentation and commercial points are commonly reviewed before buying Mitomycin C 50-07-7?
For pharmaceutical API procurement, buyers commonly align on specification review, target market, batch or annual demand, packaging expectations, and the documentation package needed for the project.
Request a Quote
If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.