Chlorambucil: Aromatic Nitrogen Mustard Alkylating Agent
Chlorambucil is the slowest-acting and least toxic of the nitrogen mustard alkylating agents. It crosslinks DNA by forming covalent bonds with nucleophilic sites on DNA bases, primarily at the N-7 position of guanine. Its aromatic ring structure slows the rate of alkylation, giving it a milder side effect profile compared to other nitrogen mustards such as cyclophosphamide.
Product Profile
| CAS Number | 305-03-3 |
|---|---|
| Molecular Formula | C14H19Cl2NO2 |
| Appearance | Off-white to pale yellow crystalline powder |
| Therapeutic Category | Antineoplastic / Alkylating Agent |
| Storage | Store at 2–8°C |
Applications
Chlorambucil is administered orally for chronic lymphocytic leukemia (CLL), low-grade non-Hodgkin’s lymphoma, Waldenström’s macroglobulinemia, and advanced ovarian cancer. Its oral bioavailability and relatively mild toxicity profile make it suitable for elderly patients and those with comorbidities. In veterinary oncology, chlorambucil is widely used in dogs and cats for the treatment of lymphoma, chronic lymphocytic leukemia, and immune-mediated conditions such as inflammatory bowel disease. It is typically formulated as 2 mg tablets and may be used in continuous low-dose or intermittent high-dose schedules.
Why Source from TCS
TCS supplies chlorambucil to pharmaceutical companies across Europe and globally. Flexible order quantities from development samples to commercial volumes. Contact us with your target market and project requirements for a tailored quotation.
FAQ
What information should be included in an inquiry for Chlorambucil 305-03-3?
A useful inquiry normally includes the product name, target application, estimated quantity, destination market, and any specific documentation or packaging requests.
How is Chlorambucil 305-03-3 usually evaluated for sourcing?
This product is positioned for pharmaceutical sourcing discussions covering development, pilot, or commercial demand, subject to the buyer confirming application scope, market, and document requirements.
What documentation and commercial points are commonly reviewed before buying Chlorambucil 305-03-3?
For pharmaceutical API procurement, buyers commonly align on specification review, target market, batch or annual demand, packaging expectations, and the documentation package needed for the project.
Request a Quote
If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.