TCS Industries Limited (China-sourced API supplier) supplies Vincristine Sulfate — API CAS 2068-78-2 for pharmaceutical B2B procurement — COA, MSDS, and technical documentation available on request.
> Overview
| Product Name | Vincristine Sulfate |
|---|---|
| Structural Formula |  |
| CAS Number | 2068-78-2 |
| Molecular Formula | C46H58N4O14S |
| Molecular Weight | 923.0 g/mol |
| InChIKey | AQTQHPDCURKLKT-JKDPCDLQSA-N |
| SMILES | Available on request where applicable |
| Appearance | White to slightly yellow hygroscopic powder |
| Purity / Grade | By agreed specification and batch COA |
| Storage | Store at 2–8°C, protect from light |
Vincristine Sulfate (CAS 2068-78-2) is a vinca alkaloid antineoplastic agent with the formula C₄₆H₅₆N₄O₁₀·H₂SO₄ (MW 923.04). Extracted from Catharanthus roseus (Madagascar periwinkle), vincristine binds tubulin and inhibits microtubule assembly, arresting cells in mitosis. It is used in combination chemotherapy for acute leukemia, lymphoma, and pediatric tumors, and is on the WHO Model List of Essential Medicines.
TCS Industries Limited, a Hong Kong-based trading and sourcing company, supplies Vincristine Sulfate API in pharmaceutical grade for global procurement programs.
> Applications
Lymphoma and leukemia chemotherapy
Vincristine is a key component of CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) for non-Hodgkin lymphoma, ABVD for Hodgkin lymphoma, and induction regimens for acute lymphoblastic leukemia (ALL). It is administered IV at 1.4 mg/m² (maximum 2 mg) weekly or every 3–4 weeks depending on the protocol. Pui et al. (N Engl J Med, 2006, 354:166–178) described the central role of vincristine in multi-agent induction chemotherapy protocols for pediatric ALL, achieving >95% complete remission rates.
Pediatric solid tumors
Vincristine is used in combination regimens for Wilms tumor, rhabdomyosarcoma, Ewing sarcoma, neuroblastoma, and medulloblastoma. Its non-myelosuppressive profile (primary toxicity is neurotoxicity) makes it combinable with myelosuppressive agents without additive marrow toxicity.
> Sourcing & Supply
TCS Industries Limited supports development, qualification and commercial purchasing discussions for Vincristine Sulfate with buyers in Australia, New Zealand, Canada and South Korea.
- Evaluation and commercial quantities: 1 g samples for analytical qualification; 10 g and 100 g for production. Plant extraction-derived pharmaceutical-grade powder. Cytotoxic API — containment required. DMF reference letters available.
- Pallet quantities and production campaigns: repeat supply is coordinated against packaging, lead time, annual demand and destination-market import requirements.
> Quality & Documentation
Key specification parameters include assay (≥90.0% on anhydrous basis), related substances (vinblastine ≤0.5%), specific optical rotation, water content, residual solvents, heavy metals, and microbial limits. White to slightly yellow amorphous powder. Soluble in methanol and water. Hygroscopic. Handle as cytotoxic material. Identity by HPLC and UV-Vis. Meets USP (Vincristine Sulfate), Ph.Eur. (Vincristini sulfas), and BP. COA and MSDS are standard.
> Packaging
Vincristine sulfate is a white to slightly yellow hygroscopic amorphous powder, cytotoxic. Standard packaging includes sealed amber glass vials under nitrogen (1 g, 5 g, or 10 g). Store at 2–8 °C. Protect from light. Cytotoxic substance labeling applies. Shelf life is typically 24 months at 2–8 °C. Labels and documents are checked before dispatch.
> Pricing & MOQ
Pricing is quoted by specification, packaging and destination. Common commercial discussions use 25 kg bag/drum formats, pallet quantities and production-campaign planning; smaller samples may be reviewed for qualified formulation teams.
> Regulatory & Compounding Context
Vincristine sulfate is monographed in USP, Ph.Eur. (Vincristini sulfas), BP, and JP. FDA-approved (Oncovin, 1963). Liposomal vincristine (Marqibo) approved in 2012 for ALL. On the WHO Model List of Essential Medicines. Generic vincristine injection available. DMF support available.
> Alias Index
- INN: Vincristine
- CAS Number: 2068-78-2 (sulfate); 57-22-7 (free base)
- Formula: C₄₆H₅₆N₄O₁₀·H₂SO₄ (MW 923.04)
- Source: Catharanthus roseus (Madagascar periwinkle)
- Brand names: Oncovin, Marqibo (liposomal)
- ATC code: L01CA02
- Related: Vinblastine, Vinorelbine, Vindesine
- Commercial request terms: vincristine sulfate API, Oncovin generic, vinca alkaloid API, CHOP regimen, ALL chemotherapy, TCS Industries Limited
> FAQ
Why is there a 2 mg dose cap?
Vincristine dose is typically capped at 2 mg per administration to limit neurotoxicity, regardless of body surface area. Above 2 mg, the incidence of severe peripheral neuropathy (foot drop, constipation, autonomic dysfunction) increases significantly. Some pediatric protocols allow exceeding the cap based on pharmacokinetic data, but this remains controversial.
What documents are available for Vincristine Sulfate orders?
COA and MSDS are standard for commercial discussions. COO, packing list, invoice and other import-support documents can be arranged according to order scope.
Do you supply Vincristine Sulfate to Australia and Canada?
Yes. We support B2B buyers in Australia, New Zealand, Canada and South Korea, subject to route and document review.
Do you supply New Zealand and South Korea?
Yes. We review Australia, New Zealand, Canada and South Korea for project supply, import documents, packaging and logistics planning before quotation.
Why must Vincristine never be given intrathecally?
Intrathecal vincristine is uniformly fatal. It causes ascending paralysis, coma, and death within days. Vincristine binds CNS tubulin irreversibly. Multiple safety systems (syringe labeling, separate preparation, “NOT for intrathecal use” warnings) are mandated to prevent this error. WHO recommends IV vincristine be dispensed in minibags, not syringes.
How is Vincristine extracted?
Vincristine is extracted from the leaves of Catharanthus roseus, where it occurs at extremely low concentrations (~0.0003% of leaf dry weight). Large-scale leaf extraction, chromatographic separation from vinblastine and other alkaloids, and crystallization are required. Semi-synthetic coupling of catharanthine and vindoline intermediates is an alternative production method.
Can you arrange samples before commercial purchasing?
Samples or evaluation quantities may be reviewed for qualified buyers after target specification, application and destination-market requirements are clarified.
How is Vincristine Sulfate packaged for export?
Packaging is confirmed by quantity and material properties. Typical options include foil bags, HDPE containers, fibre drums, 25 kg bags or palletized export packaging.
Can buyer-defined specifications be reviewed?
Yes. Send the specification, methods, impurity limits and required documents. TCS can review feasibility before confirming quotation and lead time.
What payment terms are normally used?
Standard payment is 100% T/T before dispatch unless a different arrangement has been approved for an established commercial account.
What lead time should buyers expect?
Lead time depends on stock, batch size, document scope and destination. Available stock can move faster; made-to-order or pallet programs require longer planning.
Is a DMF available?
Yes. TCS sources vincristine sulfate from manufacturers who maintain active DMFs with the FDA and ASMF/CEP with EMA. Plant extraction-derived material with validated supply chain. Cytotoxic API containment and cold chain logistics are standard. COA, stability data, and DMF reference letters provided.
Last reviewed: June 2026
Evaluation and research orders (≤10 kg) are shipped with COA, MSDS, and certificate of origin. Bulk commercial orders (>10 kg) qualify for volume pricing with a full technical documentation package available on request.
> Request a Quote
If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.