Mycophenolic Acid: Inosine Monophosphate Dehydrogenase (IMPDH) Inhibitor
Mycophenolic acid (MPA) is a potent, selective, non-competitive, and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH), a key enzyme in the de novo synthesis of guanosine nucleotides. Since lymphocytes are uniquely dependent on the de novo pathway (lacking the salvage pathway available to other cell types), MPA selectively suppresses T and B lymphocyte proliferation without broadly affecting other rapidly dividing cells.
Product Profile
| CAS Number | 24280-93-1 |
|---|---|
| Molecular Formula | C17H20O6 |
| Appearance | White to off-white crystalline powder |
| Therapeutic Category | Immunosuppressant |
| Storage | Store at controlled room temperature, protect from moisture |
Applications
Mycophenolic acid, in the form of its prodrug mycophenolate mofetil (CellCept) or as enteric-coated mycophenolate sodium (Myfortic), is a standard component of immunosuppressive regimens for the prevention of organ rejection after kidney, heart, and liver transplantation. It is used in combination with calcineurin inhibitors and corticosteroids. Off-label, mycophenolic acid is used in the treatment of autoimmune conditions including lupus nephritis, myasthenia gravis, and pemphigus vulgaris. Gastrointestinal side effects are common and may be mitigated by the enteric-coated sodium salt formulation.
Why Source from TCS
TCS supplies mycophenolic acid to pharmaceutical companies across Europe and globally. Flexible order quantities from development samples to commercial volumes. Contact us with your target market and project requirements for a tailored quotation.
FAQ
What information should be included in an inquiry for Mycophenolic Acid 24280-93-1?
A useful inquiry normally includes the product name, target application, estimated quantity, destination market, and any specific documentation or packaging requests.
How is Mycophenolic Acid 24280-93-1 usually evaluated for sourcing?
This product is positioned for pharmaceutical sourcing discussions covering development, pilot, or commercial demand, subject to the buyer confirming application scope, market, and document requirements.
What documentation and commercial points are commonly reviewed before buying Mycophenolic Acid 24280-93-1?
For pharmaceutical API procurement, buyers commonly align on specification review, target market, batch or annual demand, packaging expectations, and the documentation package needed for the project.
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