Tobramycin Sulfate: Aminoglycoside Antibiotic
Tobramycin is an aminoglycoside antibiotic produced by Streptomyces tenebrarius. It binds irreversibly to the 30S ribosomal subunit, causing misreading of mRNA and inhibiting bacterial protein synthesis. Tobramycin exhibits concentration-dependent bactericidal activity and has particular potency against Pseudomonas aeruginosa, often surpassing gentamicin in this regard.
Product Profile
| CAS Number | 79645-27-5 |
|---|---|
| Molecular Formula | C18H37N5O9 · H2SO4 |
| Appearance | White to off-white hygroscopic powder |
| Therapeutic Category | Aminoglycoside Antibiotic |
| Storage | Store at controlled room temperature |
Applications
Tobramycin sulfate is used parenterally (IM/IV) for serious gram-negative infections including septicemia, lower respiratory tract infections, intra-abdominal infections, and complicated urinary tract infections. Inhaled tobramycin (nebulizer solution and dry powder inhaler) is a cornerstone of chronic Pseudomonas aeruginosa suppressive therapy in cystic fibrosis patients, delivered in alternating 28-day on/off cycles. Ophthalmic tobramycin solution and ointment (0.3%) are used for bacterial conjunctivitis and keratitis. Therapeutic drug monitoring with peak and trough levels is essential for parenteral use to optimize efficacy and minimize ototoxicity and nephrotoxicity.
Why Source from TCS
TCS supplies tobramycin sulfate to pharmaceutical companies across Europe and globally. Flexible order quantities from development samples to commercial volumes. Contact us with your target market and project requirements for a tailored quotation.
FAQ
What information should be included in an inquiry for Tobramycin Sulfate 79645-27-5?
A useful inquiry normally includes the product name, target application, estimated quantity, destination market, and any specific documentation or packaging requests.
How is Tobramycin Sulfate 79645-27-5 usually evaluated for sourcing?
This product is positioned for pharmaceutical sourcing discussions covering development, pilot, or commercial demand, subject to the buyer confirming application scope, market, and document requirements.
What documentation and commercial points are commonly reviewed before buying Tobramycin Sulfate 79645-27-5?
For pharmaceutical API procurement, buyers commonly align on specification review, target market, batch or annual demand, packaging expectations, and the documentation package needed for the project.
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