Tamoxifen: Selective Estrogen Receptor Modulator (SERM)
Tamoxifen is a non-steroidal selective estrogen receptor modulator (SERM) that acts as an estrogen antagonist in breast tissue while exhibiting partial agonist activity in other tissues such as the endometrium and bone. It competes with estradiol for binding to estrogen receptors, blocking estrogen-driven tumor cell proliferation. Tamoxifen remains a cornerstone of endocrine therapy in hormone receptor-positive breast cancer.
Product Profile
| CAS Number | 10540-29-1 |
|---|---|
| Molecular Formula | C26H29NO |
| Appearance | White crystalline powder |
| Therapeutic Category | Antineoplastic / SERM |
| Storage | Store at controlled room temperature, protect from light |
Applications
Tamoxifen is indicated for the adjuvant treatment of hormone receptor-positive early breast cancer, reducing the risk of recurrence and contralateral breast cancer. It is also used in the treatment of metastatic breast cancer in both pre- and postmenopausal women. As a chemopreventive agent, it is approved for risk reduction in women at high risk of developing breast cancer. Tamoxifen is formulated as oral tablets, typically at 20 mg daily. Its active metabolite, endoxifen, is primarily responsible for the pharmacological activity, with metabolism dependent on CYP2D6 enzyme activity.
Why Source from TCS
TCS supplies tamoxifen to pharmaceutical companies across Europe and globally. Flexible order quantities from development samples to commercial volumes. Contact us with your target market and project requirements for a tailored quotation.
FAQ
What information should be included in an inquiry for Tamoxifen 10540-29-1?
A useful inquiry normally includes the product name, target application, estimated quantity, destination market, and any specific documentation or packaging requests.
How is Tamoxifen 10540-29-1 usually evaluated for sourcing?
This product is positioned for pharmaceutical sourcing discussions covering development, pilot, or commercial demand, subject to the buyer confirming application scope, market, and document requirements.
What documentation and commercial points are commonly reviewed before buying Tamoxifen 10540-29-1?
For pharmaceutical API procurement, buyers commonly align on specification review, target market, batch or annual demand, packaging expectations, and the documentation package needed for the project.
Request a Quote
If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.