Mirtazapine: Noradrenergic and Specific Serotonergic Antidepressant (NaSSA)
Mirtazapine is a tetracyclic piperazinoazepine antidepressant with a unique dual mechanism. It acts as an antagonist at central presynaptic α2-adrenergic autoreceptors and heteroreceptors, increasing noradrenergic and serotonergic neurotransmission. Simultaneously, it blocks 5-HT2A, 5-HT2C, 5-HT3, and H1 histamine receptors, which accounts for its anxiolytic, antiemetic, appetite-stimulating, and sedative properties.
Product Profile
| CAS Number | 85650-52-8 |
|---|---|
| Molecular Formula | C17H19N3 |
| Appearance | White to off-white crystalline powder |
| Therapeutic Category | Antidepressant (NaSSA) |
| Storage | Room temperature, protect from light and moisture |
Applications
Mirtazapine is indicated for major depressive disorder (MDD) at doses of 15–45 mg daily. Its sedative and appetite-stimulating effects at lower doses make it particularly useful in depressed patients with insomnia and weight loss. Orally disintegrating tablet (ODT) formulations are available for patients with swallowing difficulties. Off-label uses include treatment of insomnia, post-traumatic stress disorder (PTSD), and chemotherapy-induced nausea. Mirtazapine is also used in veterinary medicine as an appetite stimulant in cats.
Why Source from TCS
TCS supplies mirtazapine to pharmaceutical companies across Europe and globally. Flexible order quantities from development samples to commercial volumes. Contact us with your target market and project requirements for a tailored quotation.
FAQ
What information should be included in an inquiry for Mirtazapine 85650-52-8?
A useful inquiry normally includes the product name, target application, estimated quantity, destination market, and any specific documentation or packaging requests.
How is Mirtazapine 85650-52-8 usually evaluated for sourcing?
This product is positioned for pharmaceutical sourcing discussions covering development, pilot, or commercial demand, subject to the buyer confirming application scope, market, and document requirements.
What documentation and commercial points are commonly reviewed before buying Mirtazapine 85650-52-8?
For pharmaceutical API procurement, buyers commonly align on specification review, target market, batch or annual demand, packaging expectations, and the documentation package needed for the project.
Request a Quote
If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.