Milrinone: Phosphodiesterase III Inhibitor for Acute Heart Failure
Milrinone is a bipyridine phosphodiesterase III (PDE3) inhibitor that acts as both a positive inotrope and a vasodilator — a combination termed “inodilator.” By inhibiting PDE3, milrinone increases intracellular cyclic AMP (cAMP) in cardiac myocytes and vascular smooth muscle, resulting in enhanced myocardial contractility and peripheral vasodilation without increasing myocardial oxygen demand to the same extent as catecholamines.
Product Profile
| CAS Number | 78415-72-2 |
|---|---|
| Molecular Formula | C12H9N3O |
| Appearance | Off-white to tan crystalline powder |
| Therapeutic Category | Cardiac inotrope / vasodilator |
| Storage | Room temperature, protect from light |
Applications
Milrinone is administered intravenously for the short-term treatment of acute decompensated heart failure in patients who have not responded adequately to conventional therapy. It is used in intensive care settings, typically with a loading dose of 50 µg/kg followed by a continuous infusion of 0.375–0.75 µg/kg/min. Milrinone is also used perioperatively in cardiac surgery to facilitate weaning from cardiopulmonary bypass. In pediatric cardiology, it is employed for low cardiac output syndrome following corrective surgery for congenital heart defects.
Why Source from TCS
TCS supplies milrinone to pharmaceutical companies across Europe and globally. Flexible order quantities from development samples to commercial volumes. Contact us with your target market and project requirements for a tailored quotation.
FAQ
What information should be included in an inquiry for Milrinone 78415-72-2?
A useful inquiry normally includes the product name, target application, estimated quantity, destination market, and any specific documentation or packaging requests.
How is Milrinone 78415-72-2 usually evaluated for sourcing?
This product is positioned for pharmaceutical sourcing discussions covering development, pilot, or commercial demand, subject to the buyer confirming application scope, market, and document requirements.
What documentation and commercial points are commonly reviewed before buying Milrinone 78415-72-2?
For pharmaceutical API procurement, buyers commonly align on specification review, target market, batch or annual demand, packaging expectations, and the documentation package needed for the project.
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