TCS Industries Limited (China-sourced API supplier) supplies Milrinone — API CAS 78415-72-2 for pharmaceutical B2B procurement — COA, MSDS, and technical documentation available on request.
> Overview
| Product Name | Milrinone |
|---|---|
| Structural Formula |  |
| CAS Number | 78415-72-2 |
| Molecular Formula | C₁₂H₉N₃O |
| Molecular Weight | 211.22 g/mol |
| InChIKey | PZRHRDRVRGEVNW-UHFFFAOYSA-N |
| SMILES | Available on request where applicable |
| Appearance | Off-white to tan crystalline powder |
| Purity / Grade | By agreed specification and batch COA |
| Storage | Room temperature, protect from light |
Milrinone (CAS 78415-72-2) is a selective phosphodiesterase-3 (PDE3) inhibitor with the formula C₁₂H₉N₃O (MW 211.22). It increases intracellular cAMP in cardiac and vascular smooth muscle, producing positive inotropic (contractility) and vasodilatory effects. Milrinone is used IV for acute decompensated heart failure and is on the WHO Model List of Essential Medicines.
TCS Industries Limited, a Hong Kong-based trading and sourcing company, supplies Milrinone API in pharmaceutical grade for global procurement programs.
> Applications
Acute heart failure and cardiac surgery
Milrinone IV loading 50 μg/kg over 10 minutes, then continuous infusion 0.375–0.75 μg/kg/min, is used for acute decompensated heart failure refractory to diuretics and vasodilators. It provides both inotropic support and afterload reduction without increasing myocardial oxygen demand (unlike dobutamine). Cuffe et al. (JAMA, 2002, 287:1541–1547) evaluated milrinone in the OPTIME-CHF trial, establishing its role in acute heart failure management and identifying the patient populations most likely to benefit.
Pediatric cardiac surgery
Milrinone is used perioperatively in pediatric cardiac surgery for low cardiac output syndrome prevention. It is also used as a bridge-to-transplant therapy and in post-cardiotomy cardiogenic shock. The PRIMACORP trial established its use in pediatric patients after congenital heart surgery.
> Sourcing & Supply
TCS Industries Limited supports development, qualification and commercial purchasing discussions for Milrinone with buyers in Australia, New Zealand, Canada and South Korea.
- Evaluation and commercial quantities: 100 g samples for analytical qualification; 1 kg and 5 kg for production. Pharmaceutical (USP/Ph.Eur.) grade crystalline powder. DMF reference letters available.
- Pallet quantities and production campaigns: repeat supply is coordinated against packaging, lead time, annual demand and destination-market import requirements.
> Quality & Documentation
Key specification parameters include assay (≥98.5%), related substances (individual ≤0.2%, total ≤0.5%), loss on drying, residue on ignition, heavy metals, residual solvents, and microbial limits. Off-white to tan crystalline powder. Slightly soluble in water, soluble in DMSO. Melting point >300 °C. Identity by HPLC, UV-Vis, and IR. Meets USP (Milrinone) and Ph.Eur. COA and MSDS are standard.
> Packaging
Milrinone is an off-white to tan crystalline powder. Standard packaging includes double PE-lined foil bags in fibre drums (100 g, 500 g, 1 kg, or 5 kg). Store at controlled room temperature (15–25 °C). Protect from light. Shelf life is typically 36 months. Labels and documents are checked before dispatch.
> Pricing & MOQ
Pricing is quoted by specification, packaging and destination. Common commercial discussions use 25 kg bag/drum formats, pallet quantities and production-campaign planning; smaller samples may be reviewed for qualified formulation teams.
> Regulatory & Compounding Context
Milrinone is monographed in USP and Ph.Eur. FDA-approved in 1987 (Primacor). On the WHO Model List of Essential Medicines. Generic milrinone injection and milrinone lactate solutions available. Listed in the FDA IID for parenteral dosage forms. DMF support available.
> Alias Index
- INN: Milrinone
- CAS Number: 78415-72-2
- Formula: C₁₂H₉N₃O (MW 211.22)
- Brand name: Primacor (Sanofi)
- ATC code: C01CE02
- Pharmacological class: PDE3 inhibitor (inodilator)
- Commercial request terms: milrinone API, Primacor generic, PDE3 inhibitor, inotrope API, cardiac surgery API, TCS Industries Limited
> FAQ
How does Milrinone work as an inodilator?
Milrinone inhibits PDE3, preventing cAMP breakdown. In cardiomyocytes, elevated cAMP increases calcium influx (positive inotropy). In vascular smooth muscle, elevated cAMP causes relaxation (vasodilation). This dual inotropic + vasodilatory effect is termed “inodilation.” Unlike beta-agonists, milrinone does not require functional beta-receptors, making it effective in receptor-downregulated heart failure.
What documents are available for Milrinone orders?
COA and MSDS are standard for commercial discussions. COO, packing list, invoice and other import-support documents can be arranged according to order scope.
Do you supply Milrinone to Australia and Canada?
Yes. We support B2B buyers in Australia, New Zealand, Canada and South Korea, subject to route and document review.
Do you supply New Zealand and South Korea?
Yes. We review Australia, New Zealand, Canada and South Korea for project supply, import documents, packaging and logistics planning before quotation.
Why is long-term oral Milrinone not used?
The PROMISE trial showed that oral milrinone increased mortality by 28% compared to placebo in chronic heart failure. Long-term PDE3 inhibition causes proarrhythmic effects (increased sudden death). Milrinone is therefore restricted to short-term IV use in acute settings only. This limitation applies to all PDE3 inhibitors.
What dose adjustment is needed in renal failure?
Milrinone is ~80% renally eliminated. Infusion rate must be reduced in renal impairment: CrCl 50 mL/min → reduce by 25%; CrCl 30 mL/min → reduce by 50%; CrCl 10 mL/min → reduce by 70%. Without adjustment, accumulation causes hypotension and arrhythmia.
Can you arrange samples before commercial purchasing?
Samples or evaluation quantities may be reviewed for qualified buyers after target specification, application and destination-market requirements are clarified.
How is Milrinone packaged for export?
Packaging is confirmed by quantity and material properties. Typical options include foil bags, HDPE containers, fibre drums, 25 kg bags or palletized export packaging.
Can buyer-defined specifications be reviewed?
Yes. Send the specification, methods, impurity limits and required documents. TCS can review feasibility before confirming quotation and lead time.
What payment terms are normally used?
Standard payment is 100% T/T before dispatch unless a different arrangement has been approved for an established commercial account.
What lead time should buyers expect?
Lead time depends on stock, batch size, document scope and destination. Available stock can move faster; made-to-order or pallet programs require longer planning.
Is a DMF available?
Yes. TCS sources milrinone from manufacturers who maintain active DMFs with the FDA and equivalent regulatory submissions. Generic milrinone injection is available in the US. COA, stability data, and DMF reference letters are provided.
Last reviewed: June 2026
Evaluation and research orders (≤10 kg) are shipped with COA, MSDS, and certificate of origin. Bulk commercial orders (>10 kg) qualify for volume pricing with a full technical documentation package available on request.
> Request a Quote
If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.