Gabapentin: GABA Analogue for Epilepsy and Neuropathic Pain
Gabapentin is a structural analogue of gamma-aminobutyric acid (GABA) that, despite its name, does not bind to GABA receptors or affect GABA metabolism. Its primary mechanism involves binding to the α2δ-1 subunit of voltage-gated calcium channels, reducing calcium influx and the subsequent release of excitatory neurotransmitters including glutamate, norepinephrine, and substance P.
Product Profile
| CAS Number | 60142-96-3 |
|---|---|
| Molecular Formula | C9H17NO2 |
| Appearance | White to off-white crystalline powder |
| Therapeutic Category | Anticonvulsant / neuropathic pain agent |
| Storage | Room temperature |
Applications
Gabapentin is approved as adjunctive therapy for partial-onset seizures (with and without secondary generalization) in adults and children. It is also indicated for postherpetic neuralgia in adults. Off-label use for generalized neuropathic pain, restless legs syndrome, and anxiety disorders is extensive. Typical dosing is 300–3600 mg daily in three divided doses, with titration required. Gabapentin exhibits saturable absorption (L-amino acid transporter dependent), so bioavailability decreases at higher doses. In veterinary medicine, gabapentin is widely used in dogs and cats for chronic pain management and as a pre-visit anxiolytic in cats (typically 50–100 mg per cat).
Why Source from TCS
TCS supplies gabapentin to pharmaceutical companies across Europe and globally. Flexible order quantities from development samples to commercial volumes. Contact us with your target market and project requirements for a tailored quotation.
FAQ
What information should be included in an inquiry for Gabapentin 60142-96-3?
A useful inquiry normally includes the product name, target application, estimated quantity, destination market, and any specific documentation or packaging requests.
How is Gabapentin 60142-96-3 usually evaluated for sourcing?
This product is positioned for pharmaceutical sourcing discussions covering development, pilot, or commercial demand, subject to the buyer confirming application scope, market, and document requirements.
What documentation and commercial points are commonly reviewed before buying Gabapentin 60142-96-3?
For pharmaceutical API procurement, buyers commonly align on specification review, target market, batch or annual demand, packaging expectations, and the documentation package needed for the project.
Request a Quote
If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.