TCS Industries Limited (China-sourced API supplier) supplies Gabapentin — API CAS 60142-96-3 for pharmaceutical B2B procurement — COA, MSDS, and technical documentation available on request.
> Overview
| Product Name | Gabapentin |
|---|---|
| Structural Formula |  |
| CAS Number | 60142-96-3 |
| Molecular Formula | C₉H₁₇NO₂ |
| Molecular Weight | 171.24 g/mol |
| InChIKey | UGJMXCAKCUNAIE-UHFFFAOYSA-N |
| SMILES | Available on request where applicable |
| Appearance | White to off-white crystalline powder |
| Purity / Grade | By agreed specification and batch COA |
| Storage | Room temperature |
Gabapentin (CAS 60142-96-3) is a structural analog of GABA (gamma-aminobutyric acid) with the formula C₉H₁₇NO₂ (MW 171.24). Despite its GABA-like structure, gabapentin does not bind GABA receptors or affect GABA metabolism. Its primary target is the α₂δ-1 subunit of voltage-gated calcium channels, reducing calcium influx and excitatory neurotransmitter release. Gabapentin is used for epilepsy, neuropathic pain, and restless leg syndrome.
TCS Industries Limited, a Hong Kong-based trading and sourcing company, supplies Gabapentin API in pharmaceutical grade for global procurement programs.
> Applications
Neuropathic pain and epilepsy
Gabapentin 900–3600 mg daily in divided doses is used for postherpetic neuralgia, diabetic peripheral neuropathy, and as adjunctive therapy for partial seizures. It binds the α₂δ-1 subunit of presynaptic calcium channels, reducing excitatory neurotransmitter release (glutamate, norepinephrine, substance P). Taylor et al. (J Pain Symptom Manage, 1998, 15:112–120) provided early clinical evidence for the analgesic efficacy of gabapentin in neuropathic pain syndromes and its tolerability profile.
Off-label uses
Gabapentin is used off-label for anxiety disorders, alcohol withdrawal, hot flashes, fibromyalgia, and insomnia. Extended-release gabapentin enacarbil (Horizant) is approved for restless leg syndrome and postherpetic neuralgia with improved pharmacokinetics (once-daily dosing).
> Sourcing & Supply
TCS Industries Limited supports development, qualification and commercial purchasing discussions for Gabapentin with buyers in Australia, New Zealand, Canada and South Korea.
- Evaluation and commercial quantities: 5 kg samples for formulation development; 25 kg and 100 kg for production. Pharmaceutical (USP/Ph.Eur.) grade. High-volume API. DMF reference letters available.
- Pallet quantities and production campaigns: repeat supply is coordinated against packaging, lead time, annual demand and destination-market import requirements.
> Quality & Documentation
Key specification parameters include assay (≥99.0%), related substances (gabapentin-lactam ≤0.4%), loss on drying, residue on ignition, heavy metals, residual solvents, and microbial limits. White to off-white crystalline powder. Freely soluble in water. Amphoteric — soluble in acidic and alkaline solutions. Melting point 162–166 °C. Identity by HPLC, IR, and melting point. Meets USP (Gabapentin) and Ph.Eur. (Gabapentinum). COA and MSDS are standard.
> Packaging
Gabapentin is a white to off-white crystalline powder. Standard packaging includes double PE-lined foil bags in fibre drums (5 kg, 25 kg, or 50 kg). Store at controlled room temperature (15–25 °C). Protect from moisture. Shelf life is typically 36 months. Labels and documents are checked before dispatch.
> Pricing & MOQ
Pricing is quoted by specification, packaging and destination. Common commercial discussions use 25 kg bag/drum formats, pallet quantities and production-campaign planning; smaller samples may be reviewed for qualified formulation teams.
> Regulatory & Compounding Context
Gabapentin is monographed in USP and Ph.Eur. (Gabapentinum). FDA-approved in 1993 (Neurontin) for epilepsy and 2002 for postherpetic neuralgia. Gabapentin enacarbil (Horizant) approved for RLS (2011). On the WHO Model List of Essential Medicines. Off-patent with extensive generic availability. Scheduled as a controlled substance in some jurisdictions due to misuse potential. DMF support available.
> Alias Index
- INN: Gabapentin
- CAS Number: 60142-96-3
- Formula: C₉H₁₇NO₂ (MW 171.24)
- Brand names: Neurontin, Horizant (enacarbil prodrug)
- ATC code: N03AX12
- Target: α₂δ-1 subunit of voltage-gated calcium channels
- Related: Pregabalin (more potent α₂δ ligand)
- Commercial request terms: gabapentin API, Neurontin generic, neuropathic pain API, anticonvulsant API, TCS Industries Limited
> FAQ
How does Gabapentin differ from Pregabalin?
Both bind the α₂δ-1 calcium channel subunit, but pregabalin has higher binding affinity (6× stronger), linear pharmacokinetics (vs. gabapentin saturable L-amino acid transport), twice-daily dosing (vs. three times daily), and is 2–3× more potent. Pregabalin is Schedule V in the US; gabapentin scheduling varies by jurisdiction.
What documents are available for Gabapentin orders?
COA and MSDS are standard for commercial discussions. COO, packing list, invoice and other import-support documents can be arranged according to order scope.
Do you supply Gabapentin to Australia and Canada?
Yes. We support B2B buyers in Australia, New Zealand, Canada and South Korea, subject to route and document review.
Do you supply New Zealand and South Korea?
Yes. We review Australia, New Zealand, Canada and South Korea for project supply, import documents, packaging and logistics planning before quotation.
Why does Gabapentin have saturable absorption?
Gabapentin is absorbed via the L-amino acid transporter (LAT1/SLC7A5) in the small intestine. This active transport system is saturable — bioavailability decreases from ~60% at 300 mg to ~35% at 1600 mg per dose. Splitting high daily doses into 3–4 doses helps maintain absorption. Gabapentin enacarbil uses a different transporter to overcome this limitation.
Is there a misuse concern?
Gabapentin misuse has increased, particularly in combination with opioids (potentiation of euphoria and respiratory depression). Several US states and the UK have reclassified gabapentin as a controlled substance. Monitoring for aberrant use patterns is recommended, especially in patients with substance use disorder history.
Can you arrange samples before commercial purchasing?
Samples or evaluation quantities may be reviewed for qualified buyers after target specification, application and destination-market requirements are clarified.
How is Gabapentin packaged for export?
Packaging is confirmed by quantity and material properties. Typical options include foil bags, HDPE containers, fibre drums, 25 kg bags or palletized export packaging.
Can buyer-defined specifications be reviewed?
Yes. Send the specification, methods, impurity limits and required documents. TCS can review feasibility before confirming quotation and lead time.
What payment terms are normally used?
Standard payment is 100% T/T before dispatch unless a different arrangement has been approved for an established commercial account.
What lead time should buyers expect?
Lead time depends on stock, batch size, document scope and destination. Available stock can move faster; made-to-order or pallet programs require longer planning.
Is a DMF available?
Yes. TCS sources gabapentin from manufacturers who maintain active DMFs with the FDA and ASMF/CEP with EMA. High-volume API production. Off-patent with extensive generic competition. COA, stability data, and DMF reference letters provided.
Last reviewed: June 2026
Evaluation and research orders (≤10 kg) are shipped with COA, MSDS, and certificate of origin. Bulk commercial orders (>10 kg) qualify for volume pricing with a full technical documentation package available on request.
> Request a Quote
If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.