Clomipramine: Tricyclic Antidepressant with Serotonergic Selectivity
Clomipramine is a dibenzazepine tricyclic antidepressant (TCA) that is the most serotonin-selective of the classical TCAs. It potently inhibits serotonin (5-HT) reuptake, while its active metabolite desmethylclomipramine inhibits norepinephrine reuptake. This dual-action profile makes it particularly effective for obsessive-compulsive disorder, distinguishing it from other TCAs.
Product Profile
| CAS Number | 303-49-1 |
|---|---|
| Molecular Formula | C19H23ClN2 |
| Appearance | White to off-white crystalline powder |
| Therapeutic Category | Tricyclic antidepressant |
| Storage | Room temperature, protect from light |
Applications
Clomipramine is approved for the treatment of obsessive-compulsive disorder (OCD) in adults and children, and remains a benchmark comparator for this indication. It is also used for major depression, panic disorder, and chronic pain syndromes. Typical oral dosing ranges from 25–250 mg daily in divided doses. In veterinary behavioral medicine, clomipramine is approved for separation anxiety in dogs (1–2 mg/kg twice daily) and is used off-label in cats for urine spraying, compulsive disorders, and anxiety-related behaviors. The veterinary formulation is available as flavored tablets.
Why Source from TCS
TCS supplies clomipramine to pharmaceutical and veterinary pharmaceutical companies across Europe and globally. Flexible order quantities from development samples to commercial volumes. Contact us with your target market and project requirements for a tailored quotation.
FAQ
What information should be included in an inquiry for Clomipramine 303-49-1?
A useful inquiry normally includes the product name, target application, estimated quantity, destination market, and any specific documentation or packaging requests.
How is Clomipramine 303-49-1 usually evaluated for sourcing?
This product is positioned for pharmaceutical sourcing discussions covering development, pilot, or commercial demand, subject to the buyer confirming application scope, market, and document requirements.
What documentation and commercial points are commonly reviewed before buying Clomipramine 303-49-1?
For pharmaceutical API procurement, buyers commonly align on specification review, target market, batch or annual demand, packaging expectations, and the documentation package needed for the project.
Request a Quote
If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.