TCS Industries Limited (China-sourced API supplier) supplies Clomipramine — API CAS 303-49-1 for pharmaceutical B2B procurement — COA, MSDS, and technical documentation available on request.
> Overview
| Product Name | Clomipramine |
|---|---|
| Structural Formula |  |
| CAS Number | 303-49-1 |
| Molecular Formula | C₁₉H₂₃ClN₂ |
| Molecular Weight | 314.9 g/mol |
| InChIKey | GDLIGKIOYRNHDA-UHFFFAOYSA-N |
| SMILES | Available on request where applicable |
| Appearance | White to off-white crystalline powder |
| Purity / Grade | By agreed specification and batch COA |
| Storage | Room temperature, protect from light |
Clomipramine (CAS 303-49-1) is a tricyclic antidepressant (TCA) with the formula C₁₉H₂₃ClN₂ (MW 314.85, as free base). It is the 3-chloro derivative of imipramine and is the most serotonergic of the TCAs, potently inhibiting serotonin reuptake. Clomipramine is used for obsessive-compulsive disorder (OCD), depression, and various anxiety disorders.
TCS Industries Limited, a Hong Kong-based trading and sourcing company, supplies Clomipramine HCl API in pharmaceutical grade for global procurement programs.
> Applications
Obsessive-compulsive disorder
Clomipramine 75–250 mg daily is the first medication approved for OCD and remains effective for treatment-resistant OCD. Its potent serotonin reuptake inhibition (SRI, Ki = 0.28 nM) makes it the most serotonergic TCA — comparable to SSRIs for OCD efficacy. The active metabolite desmethylclomipramine adds noradrenergic activity. Clomipramine Collaborative Study Group (Arch Gen Psychiatry, 1991, 48:730–738) established the efficacy of clomipramine in OCD across multiple centers and set the standard for subsequent OCD pharmacotherapy trials.
Depression and pain syndromes
Clomipramine is effective for depression (especially with obsessional features), panic disorder, phobic disorders, and cataplexy in narcolepsy. Like other TCAs, it is used for neuropathic pain and chronic pain syndromes at lower doses.
> Sourcing & Supply
TCS Industries Limited supports development, qualification and commercial purchasing discussions for Clomipramine with buyers in Australia, New Zealand, Canada and South Korea.
- Evaluation and commercial quantities: 500 g samples for formulation development; 5 kg and 25 kg for production. Pharmaceutical (USP/Ph.Eur.) grade. Human and veterinary grades. DMF reference letters available.
- Pallet quantities and production campaigns: repeat supply is coordinated against packaging, lead time, annual demand and destination-market import requirements.
> Quality & Documentation
Key specification parameters include assay (≥99.0%), related substances, loss on drying, residue on ignition, heavy metals, residual solvents, and microbial limits. White to off-white crystalline powder (as HCl salt). Freely soluble in water and methanol. Identity by HPLC and IR. Meets USP (Clomipramine Hydrochloride) and Ph.Eur. (Clomipramini hydrochloridum). COA and MSDS are standard.
> Packaging
Clomipramine HCl is a white to off-white crystalline powder. Standard packaging includes double PE-lined foil bags in fibre drums (1 kg, 5 kg, or 25 kg). Store at controlled room temperature (15–25 °C). Protect from light and moisture. Shelf life is typically 36 months. Labels and documents are checked before dispatch.
> Pricing & MOQ
Pricing is quoted by specification, packaging and destination. Common commercial discussions use 25 kg bag/drum formats, pallet quantities and production-campaign planning; smaller samples may be reviewed for qualified formulation teams.
> Regulatory & Compounding Context
Clomipramine HCl is monographed in USP and Ph.Eur. FDA-approved in 1989 (Anafranil) for OCD. EMA-authorized. On the WHO Model List of Essential Medicines. Off-patent with multiple generic approvals. Also approved for OCD and separation anxiety in veterinary medicine (Clomicalm). DMF support available.
> Alias Index
- INN: Clomipramine
- CAS Number: 303-49-1 (base); 17321-77-6 (HCl)
- Formula: C₁₉H₂₃ClN₂ (MW 314.85)
- Brand names: Anafranil (human), Clomicalm (veterinary)
- ATC code: N06AA04
- Active metabolite: Desmethylclomipramine (NRI)
- Commercial request terms: clomipramine HCl API, Anafranil generic, TCA for OCD, Clomicalm API, TCS Industries Limited
> FAQ
Why is Clomipramine effective for OCD?
Clomipramine is the most potent serotonin reuptake inhibitor among TCAs (Ki 0.28 nM for SERT, comparable to paroxetine). OCD pathophysiology involves serotonergic dysfunction in orbitofrontal-striatal circuits. The high SRI potency explains why clomipramine is the only TCA effective for OCD, while non-serotonergic TCAs (desipramine, nortriptyline) are not.
What documents are available for Clomipramine orders?
COA and MSDS are standard for commercial discussions. COO, packing list, invoice and other import-support documents can be arranged according to order scope.
Do you supply Clomipramine to Australia and Canada?
Yes. We support B2B buyers in Australia, New Zealand, Canada and South Korea, subject to route and document review.
Do you supply New Zealand and South Korea?
Yes. We review Australia, New Zealand, Canada and South Korea for project supply, import documents, packaging and logistics planning before quotation.
How does Clomipramine compare to SSRIs for OCD?
Meta-analyses suggest clomipramine has slightly greater efficacy than SSRIs for OCD, but its TCA side effect profile (anticholinergic effects, sedation, weight gain, cardiac conduction) limits tolerability. SSRIs (fluoxetine, fluvoxamine, sertraline, paroxetine) are first-line due to better safety. Clomipramine is reserved for SSRI-refractory OCD or used in combination (with caution regarding serotonin syndrome).
Is Clomipramine used in veterinary medicine?
Yes. Clomipramine (Clomicalm, 1–3 mg/kg twice daily) is approved in dogs for separation anxiety (combined with behavior modification). It is also used off-label for compulsive disorders, noise phobias, and urine marking in cats. The serotonergic mechanism addresses anxiety-related behavioral disorders in companion animals.
Can you arrange samples before commercial purchasing?
Samples or evaluation quantities may be reviewed for qualified buyers after target specification, application and destination-market requirements are clarified.
How is Clomipramine packaged for export?
Packaging is confirmed by quantity and material properties. Typical options include foil bags, HDPE containers, fibre drums, 25 kg bags or palletized export packaging.
Can buyer-defined specifications be reviewed?
Yes. Send the specification, methods, impurity limits and required documents. TCS can review feasibility before confirming quotation and lead time.
What payment terms are normally used?
Standard payment is 100% T/T before dispatch unless a different arrangement has been approved for an established commercial account.
What lead time should buyers expect?
Lead time depends on stock, batch size, document scope and destination. Available stock can move faster; made-to-order or pallet programs require longer planning.
Is a DMF available?
Yes. TCS sources clomipramine HCl from manufacturers who maintain active DMFs. Off-patent with generic competition. Human and veterinary grades available. COA, stability data, and DMF reference letters provided.
Last reviewed: June 2026
Evaluation and research orders (≤10 kg) are shipped with COA, MSDS, and certificate of origin. Bulk commercial orders (>10 kg) qualify for volume pricing with a full technical documentation package available on request.
> Request a Quote
If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.