Tacrolimus: Calcineurin Inhibitor Immunosuppressant
Tacrolimus (FK506) is a macrolide lactone produced by Streptomyces tsukubaensis. It binds to the intracellular protein FKBP-12, and this complex inhibits calcineurin, a phosphatase required for T-cell activation and interleukin-2 transcription. Tacrolimus is 10 to 100 times more potent than cyclosporine on a weight basis in inhibiting T-cell proliferation.
Product Profile
| CAS Number | 104987-11-3 |
|---|---|
| Molecular Formula | C44H69NO12 |
| Appearance | White to off-white crystalline powder |
| Therapeutic Category | Immunosuppressant / Calcineurin Inhibitor |
| Storage | Store at controlled room temperature, protect from moisture |
Applications
Tacrolimus is a first-line immunosuppressant for the prevention of allograft rejection following kidney, liver, and heart transplantation. It is formulated as oral capsules (immediate-release and extended-release) and as an intravenous concentrate for infusion. Topical tacrolimus ointment (0.03% and 0.1%) is approved for moderate to severe atopic dermatitis in patients who are not adequately responsive to conventional therapies. Therapeutic drug monitoring is essential due to its narrow therapeutic index, with target trough levels varying by organ transplanted and time post-transplant. In veterinary dermatology, topical tacrolimus is used for localized immune-mediated skin conditions in dogs.
Why Source from TCS
TCS supplies tacrolimus to pharmaceutical companies across Europe and globally. Flexible order quantities from development samples to commercial volumes. Contact us with your target market and project requirements for a tailored quotation.
FAQ
What information should be included in an inquiry for Tacrolimus 104987-11-3?
A useful inquiry normally includes the product name, target application, estimated quantity, destination market, and any specific documentation or packaging requests.
How is Tacrolimus 104987-11-3 usually evaluated for sourcing?
This product is positioned for pharmaceutical sourcing discussions covering development, pilot, or commercial demand, subject to the buyer confirming application scope, market, and document requirements.
What documentation and commercial points are commonly reviewed before buying Tacrolimus 104987-11-3?
For pharmaceutical API procurement, buyers commonly align on specification review, target market, batch or annual demand, packaging expectations, and the documentation package needed for the project.
Request a Quote
If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.