TCS Industries Limited (China-sourced API supplier) supplies Ademetionine Disulfate Tosylate CAS 97540-22-2 for pharmaceutical B2B procurement — COA, MSDS, and technical documentation available on request.
> Overview
| Product Name | Ademetionine Disulfate Tosylate |
|---|---|
| Structural Formula |  |
| CAS Number | 97540-22-2 |
| Molecular Formula | C22H34N6O16S4 |
| Molecular Weight | 766.8 g/mol |
| InChIKey | XDCFCHNAIMYBAZ-XQVUROGGSA-N |
| SMILES | Available on request where applicable |
| Appearance | White to off-white hygroscopic powder |
| Purity / Grade | By agreed specification and batch COA |
| Storage | Store at 2–8°C, protect from moisture and light |
Ademetionine Disulfate Tosylate (CAS 97540-22-2, also known as S-adenosylmethionine or SAMe) is the tosylate disulfate salt of S-adenosyl-L-methionine. The free form has the formula C₁₅H₂₃N₆O₅S⁺ (MW 399.44). SAMe is a naturally occurring methyl donor involved in over 100 methylation reactions in the body. It is used as a pharmaceutical for liver disease, depression, and osteoarthritis.
TCS Industries Limited, a Hong Kong-based trading and sourcing company, supplies Ademetionine Disulfate Tosylate API in pharmaceutical grade for global procurement programs.
> Applications
Hepatoprotective agent
Ademetionine restores hepatic glutathione levels and supports transmethylation reactions essential for liver cell membrane integrity. It is administered IV/IM (400–800 mg/day) or orally (800–1600 mg/day) for intrahepatic cholestasis, alcoholic liver disease, and drug-induced liver injury. Mato et al. (J Hepatol, 1999, 30:1081–1089) demonstrated that long-term SAMe administration improved survival and delayed liver transplantation in patients with alcoholic liver cirrhosis (Child-Pugh A/B).
Adjunctive antidepressant and osteoarthritis
SAMe has antidepressant activity attributed to enhanced neurotransmitter methylation (serotonin, dopamine, norepinephrine). It is used as adjunctive treatment for major depressive disorder at 400–1600 mg/day. SAMe also has anti-inflammatory effects in osteoarthritis cartilage, comparable to NSAIDs in clinical trials.
> Sourcing & Supply
TCS Industries Limited supports development, qualification and commercial purchasing discussions for Ademetionine Disulfate Tosylate with buyers in South America, Europe, the United Kingdom, Australia, New Zealand, Mexico and Canada.
- Evaluation and commercial quantities: 100 g samples for analytical qualification; 1 kg for formulation development; 5–25 kg for production. Pharmaceutical (Ph.Eur.) grade available. Cold chain logistics required.
- Pallet quantities and production campaigns: repeat supply is coordinated against packaging, lead time, annual demand and destination-market import requirements.
> Quality & Documentation
Key specification parameters include assay (≥75% on anhydrous basis for the tosylate salt), stereochemical purity ((S,S) diastereomer ≥70%), related substances, water content, tosylate content, sulfate content, residual solvents, heavy metals, and microbial limits. White to off-white hygroscopic powder. Highly unstable in solution — must be protected from moisture, heat, and light. Identity by HPLC and specific optical rotation. Meets Ph.Eur. (Ademetionini tosilas disulfas) and in-house specifications. COA and MSDS are standard.
> Packaging
Ademetionine disulfate tosylate is extremely hygroscopic and oxidation-sensitive. Standard packaging includes sealed aluminium foil bags under nitrogen or argon in fibre drums (1 kg or 5 kg). Must be stored at 2–8 °C. Protect from light, moisture, and oxygen. Shelf life is typically 18–24 months under cold storage. Labels and documents are checked before dispatch.
> Pricing & MOQ
Pricing is quoted by specification, packaging and destination. Common commercial discussions use 25 kg bag/drum formats, pallet quantities and production-campaign planning; smaller samples may be reviewed for qualified formulation teams.
> Regulatory & Compounding Context
Ademetionine is registered as a prescription pharmaceutical in Italy (Gumbaral), Germany (Gumbaral), and other EU/Asian markets for liver disease. Available as a dietary supplement (SAMe) in the US (DSHEA, not FDA-approved as drug). Ph.Eur. monograph exists (Ademetionini tosilas disulfas). Not currently USP-monographed. IV formulation is authorized in some markets. DMF support available.
> Alias Index
- INN: Ademetionine
- CAS Number: 97540-22-2 (disulfate tosylate); 29908-03-0 (free form)
- Formula: C₁₅H₂₃N₆O₅S⁺ (free cation, MW 399.44)
- Common abbreviation: SAMe (S-adenosyl-L-methionine)
- Brand names: Gumbaral, Transmetil, Samyr
- Ph.Eur. name: Ademetionini tosilas disulfas
- Commercial request terms: ademetionine tosylate API, SAMe pharmaceutical grade, S-adenosylmethionine, hepatoprotective API, TCS Industries Limited
> FAQ
Why is the Tosylate Disulfate salt form used?
The free SAMe molecule is extremely unstable — it degrades rapidly in aqueous solution and at room temperature. The tosylate disulfate salt provides improved crystallinity, handling properties, and stability. Even so, it requires cold storage and inert atmosphere packaging. The salt form does not affect pharmacological activity.
What documents are available for Ademetionine Disulfate Tosylate orders?
COA and MSDS are standard for commercial discussions. COO, packing list, invoice and other import-support documents can be arranged according to order scope.
Can TCS Industries Limited support Ademetionine Disulfate Tosylate supply to South America?
Yes. We support B2B buyers in Argentina, Colombia, Chile, Peru, Ecuador, Uruguay, Bolivia, Brazil, Paraguay, Venezuela, Guyana and Suriname, subject to route and document review.
Do you support Europe, the United Kingdom, Australia, New Zealand, Mexico and Canada?
Yes. These destinations can be reviewed for project supply, import documents, packaging and logistics planning before quotation.
What is the (S,S) diastereomer requirement?
SAMe has a chiral sulfur center, producing (S,S) and (R,S) diastereomers. Only the (S,S) form is biologically active. Ph.Eur. requires ≥70% (S,S) diastereomer. Higher (S,S) content correlates with greater biological potency. Manufacturing process and storage conditions affect diastereomeric ratio — the (S,S) form slowly converts to (R,S) over time.
Is cold chain logistics required?
Yes. Ademetionine API must be shipped under cold chain conditions (2–8 °C). Exposure to temperatures above 25 °C accelerates degradation and (S,S) to (R,S) conversion. All packaging, shipping, and warehouse storage must maintain temperature control. TCS coordinates cold chain logistics for this product.
Can you arrange samples before commercial purchasing?
Samples or evaluation quantities may be reviewed for qualified buyers after target specification, application and destination-market requirements are clarified.
How is Ademetionine Disulfate Tosylate packaged for export?
Packaging is confirmed by quantity and material properties. Typical options include foil bags, HDPE containers, fibre drums, 25 kg bags or palletized export packaging.
Can buyer-defined specifications be reviewed?
Yes. Send the specification, methods, impurity limits and required documents. TCS can review feasibility before confirming quotation and lead time.
What payment terms are normally used?
Standard payment is 100% T/T before dispatch unless a different arrangement has been approved for an established commercial account.
What lead time should buyers expect?
Lead time depends on stock, batch size, document scope and destination. Available stock can move faster; made-to-order or pallet programs require longer planning.
Why is SAMe a drug in Europe but a supplement in the US?
Regulatory classification differs by jurisdiction. In the EU, ademetionine is registered as a prescription pharmaceutical (liver disease, depression). In the US, SAMe is marketed as a dietary supplement under DSHEA because it was commercially available before the Dietary Supplement Health and Education Act of 1994. It is not FDA-approved as a drug in the US.
Last reviewed: June 2026
Evaluation and research orders (≤10 kg) are shipped with COA, MSDS, and certificate of origin. Bulk commercial orders (>10 kg) qualify for volume pricing with a full technical documentation package available on request.
> Request a Quote
If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.