TCS Industries Limited (China-sourced API supplier) supplies Cyclosporin A CAS 59865-13-3 for pharmaceutical B2B procurement — COA, MSDS, and technical documentation available on request.
> Overview
| Product Name | Cyclosporin A |
|---|---|
| Structural Formula | |
| CAS Number | 59865-13-3 |
| Molecular Formula | C62H111N11O12 |
| Molecular Weight | 1202.6 g/mol |
| InChIKey | PMATZTZNYRCHOR-CGLBZJNRSA-N |
| SMILES | Available on request where applicable |
| Appearance | White to off-white powder, hygroscopic |
| Purity / Grade | By agreed specification and batch COA |
| Storage | Keep tightly closed in a cool, dry, well-ventilated place |
Cyclosporin A (CAS 59865-13-3, also known as ciclosporin) is a cyclic undecapeptide immunosuppressant produced by Tolypocladium inflatum with the formula C₆₂H₁₁₁N₁₁O₁₂ (MW 1202.61). Cyclosporin binds cyclophilin, and the complex inhibits calcineurin, blocking T-cell activation and IL-2 production. It is used for organ transplant rejection prevention, autoimmune diseases, and dry eye, and is on the WHO Model List of Essential Medicines.
TCS Industries Limited, a Hong Kong-based trading and sourcing company, supplies Cyclosporin A API in pharmaceutical grade for global procurement programs.
> Applications
Literature context for technical review includes a 2007 journal review of cyclosporine A delivery systems (Drug Development and Industrial Pharmacy, doi: 10.1080/03639040601155665) and the earlier randomized NEJM transplant trial with n=209 recipients; TCS uses such references only to frame dossier discussion, not as a substitute for buyer-side regulatory assessment.
Transplant immunosuppression
Cyclosporin A transformed organ transplantation by enabling calcineurin-based immunosuppression. It is administered orally or intravenously with target trough levels of 100–300 ng/mL (organ and protocol dependent). The microemulsion formulation (Neoral) provides more consistent absorption than the original oil-based formulation (Sandimmune). Borel et al. (Agents Actions, 1976, 6:468–475) first described the immunosuppressive properties of cyclosporin A and its selective action on T-lymphocytes in vitro and in vivo.
Autoimmune and ophthalmic applications
Cyclosporin is used for severe autoimmune diseases including psoriasis, rheumatoid arthritis, nephrotic syndrome, and ulcerative colitis. Ophthalmic emulsion (Restasis 0.05%, Cequa 0.09%) is FDA-approved for chronic dry eye disease. Cyclosporin suppresses lacrimal gland inflammation and increases tear production.
> Sourcing & Supply
TCS Industries Limited supports development, qualification and commercial purchasing discussions for Cyclosporin A with buyers in South America, Europe, the United Kingdom, Australia, New Zealand, Mexico and Canada.
- Evaluation quantities: target specification and document needs are reviewed before dispatch.
- Commercial lots: repeat supply is arranged by specification, packaging and destination-market requirements.
> Quality & Documentation
Key specification parameters include assay (≥98.5%), related substances (cyclosporin B, C, D, E — individual ≤0.5%, total ≤2.0%), water content, residual solvents, heavy metals, and microbial limits. White to off-white powder. Practically insoluble in water, soluble in methanol, ethanol, and acetone. Identity by HPLC and IR. Meets USP (Cyclosporine), Ph.Eur. (Ciclosporinum), JP, and BP. COA and MSDS are standard.
> Packaging
Cyclosporin A is a white to off-white powder, hygroscopic. Standard packaging includes sealed aluminium foil bags under nitrogen in fibre drums (500 g, 1 kg, or 5 kg). Store at controlled room temperature (15–25 °C). Protect from light and moisture. Shelf life is typically 36 months. Labels and documents are checked before dispatch.
> Pricing & MOQ
Pricing is quoted by specification, packaging, quantity and destination. Samples, kilogram lots and commercial quantities can be discussed according to project stage.
> Regulatory & Compounding Context
Cyclosporin is monographed in USP (Cyclosporine), Ph.Eur. (Ciclosporinum), JP, and BP. FDA-approved in 1983 (Sandimmune), with microemulsion formulation (Neoral) approved in 1995. Ophthalmic emulsion (Restasis) approved in 2003. EMA-authorized. On the WHO Model List of Essential Medicines. Multiple generic and biosimilar (follow-on) products available. DMF support available.
> Alias Index
- INN: Ciclosporin (WHO), Cyclosporine (USP)
- CAS Number: 59865-13-3
- Formula: C₆₂H₁₁₁N₁₁O₁₂ (MW 1202.61)
- Brand names: Sandimmune, Neoral, Restasis, Cequa
- ATC code: L04AD01 (systemic), S01XA18 (ophthalmic)
- Pharmacological class: Calcineurin inhibitor (cyclophilin-binding)
- Commercial request terms: cyclosporin A API, ciclosporin bulk, Neoral generic, calcineurin inhibitor, TCS Industries Limited
> FAQ
What is the difference between Sandimmune and Neoral?
Sandimmune (original formulation) is an oil-based soft gelatin capsule with variable, bile-dependent absorption. Neoral (microemulsion pre-concentrate, MEPC) self-emulsifies in aqueous GI fluid, providing more consistent and higher bioavailability (AUC ~30% higher). They are NOT bioequivalent and cannot be substituted without dose adjustment and TDM.
What documents are available for Cyclosporin A orders?
COA and MSDS are standard for commercial discussions. COO, packing list, invoice and other import-support documents can be arranged according to order scope.
Can TCS Industries Limited support Cyclosporin A supply to South America?
Yes. We support B2B buyers in Argentina, Colombia, Chile, Peru, Ecuador, Uruguay, Bolivia, Brazil, Paraguay, Venezuela, Guyana and Suriname, subject to route and document review.
Do you support Europe, the United Kingdom, Australia, New Zealand, Mexico and Canada?
Yes. These destinations can be reviewed for project supply, import documents, packaging and logistics planning before quotation.
How is Cyclosporin produced?
Cyclosporin A is produced by aerobic fermentation of the fungus Tolypocladium inflatum (formerly Beauveria nivea). The cyclic undecapeptide is a secondary metabolite extracted from the fermentation broth using organic solvents, then purified by chromatography and crystallization. Chemical total synthesis is possible but not commercially viable due to the peptide complexity.
Why does Cyclosporin have variable oral absorption?
Cyclosporin A is highly lipophilic (log P ~2.9) and practically insoluble in water. Oral absorption depends on bile salt-mediated solubilization in the GI tract. The microemulsion formulation (Neoral) reduces this dependency by forming fine emulsion droplets (<100 nm) spontaneously, reducing food effect and intra-patient variability.
Can you arrange samples before commercial purchasing?
Samples or evaluation quantities may be reviewed for qualified buyers after target specification, application and destination-market requirements are clarified.
How is Cyclosporin A packaged for export?
Packaging is confirmed by quantity and material properties. Typical options include foil bags, HDPE containers, fibre drums or palletized export packaging.
Can buyer-defined specifications be reviewed?
Yes. Send the specification, methods, impurity limits and required documents. TCS can review feasibility before confirming quotation and lead time.
What payment terms are normally used?
Standard payment is 100% T/T before dispatch unless a different arrangement has been approved for an established commercial account.
What lead time should buyers expect?
Lead time depends on stock, batch size, document scope and destination. Available stock can move faster; made-to-order programs require longer planning.
Is Cyclosporin nephrotoxic?
Yes. Chronic cyclosporin nephrotoxicity (afferent arteriolar vasoconstriction, tubulointerstitial fibrosis) is the major long-term limitation. It occurs dose-dependently and is partially reversible with dose reduction. Therapeutic drug monitoring (trough 100–300 ng/mL), renal function monitoring (creatinine, GFR), and blood pressure monitoring are mandatory during treatment.
Last reviewed: June 2026
Evaluation and research orders (≤10 kg) are shipped with COA, MSDS, and certificate of origin. Bulk commercial orders (>10 kg) qualify for volume pricing with a full technical documentation package available on request.
> Request a Quote
If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.