TCS Industries Limited (China-sourced API supplier) supplies Spinosad — API CAS 131929-60-7 for pharmaceutical B2B procurement — COA, MSDS, and technical documentation available on request.
> Overview
| Product Name | Spinosad |
|---|---|
| Structural Formula |  |
| CAS Number | 131929-60-7 |
| Molecular Formula | C41H65NO10 |
| Molecular Weight | 732.0 g/mol |
| InChIKey | SRJQTHAZUNRMPR-UYQKXTDMSA-N |
| SMILES | Available on request where applicable |
| Appearance | Off-white to light grey powder |
| Purity / Grade | By agreed specification and batch COA |
| Storage | Store at controlled room temperature |
Spinosad (CAS 131929-60-7) is a natural insecticide composed of spinosyns A and D produced by Saccharopolyspora spinosa. The mixture has a combined formula and MW of ~732 (spinosyn A: C₄₁H₆₅NO₁₀, MW 731.96). Spinosad activates nicotinic acetylcholine receptors and potentiates GABA receptor function at a unique site, causing involuntary muscle contractions and death in insects. It is used in veterinary, agricultural, and public health applications.
TCS Industries Limited, a Hong Kong-based trading and sourcing company, supplies Spinosad API for veterinary oral flea treatment and agricultural insecticide formulation programs.
> Applications
Oral flea treatment for dogs
Spinosad is the active ingredient in chewable tablets for rapid flea kill in dogs (Comfortis, Elanco). Dosing is 30–60 mg/kg monthly. Flea kill begins within 30 minutes and reaches >98% efficacy within 4 hours. The oral route avoids the residue and contact concerns of topical treatments. Robertson-Plouch et al. (Vet Ther, 2008, 9:26–36) demonstrated >98% flea kill efficacy in clinical field trials. Spinosad has been combined with milbemycin oxime (Trifexis, Elanco) for simultaneous flea and heartworm protection.
Agricultural and livestock insecticide
Spinosad is used in organic farming as a permitted natural insecticide (OMRI-listed) for control of thrips, leaf miners, fruit flies and caterpillars. In livestock, it is applied as a premise spray for fly control. Agricultural formulations include suspension concentrates, wettable powders and granular baits. The dual mode of action (nAChR + GABA) delays resistance development compared to single-target insecticides.
> Sourcing & Supply
TCS Industries Limited supports development, qualification and commercial purchasing discussions for Spinosad with buyers in Australia, New Zealand, Canada and South Korea.
- Development and qualification quantities: 100 g to 10 kg packs for formulation development, palatability studies, and veterinary or agricultural registration submissions.
- Pallet quantities and production campaigns: repeat supply is coordinated against packaging, lead time, annual demand and destination-market import requirements.
> Quality & Documentation
Key specification parameters include assay (≥85% combined spinosyns A + D, A:D ratio specified), related substances, water content, residual solvents, heavy metals, and microbial limits. Off-white to light grey powder. Practically insoluble in water, soluble in methanol and acetone. Identity by HPLC and UV. Meets in-house veterinary pharmaceutical and agricultural specifications. COA and MSDS are standard.
> Packaging
Spinosad is an off-white to light grey powder. Standard packaging includes double PE-lined foil bags in fibre drums (500 g, 1 kg, 5 kg, or 25 kg). Store at controlled room temperature (15–25 °C). Protect from moisture. Shelf life is typically 24–36 months. Labels and documents are checked before dispatch.
> Pricing & MOQ
Pricing is quoted by specification, packaging and destination. Common commercial discussions use 25 kg bag/drum formats, pallet quantities and production-campaign planning; smaller samples may be reviewed for qualified formulation teams.
> Regulatory & Compounding Context
Spinosad is approved for veterinary use (Comfortis, Trifexis — Elanco), human topical use (Natroba — ParaPRO for head lice), and agricultural use. FDA-CVM approved for companion animal flea control. EPA-registered for agricultural use. Organic agriculture approved (OMRI-listed). EMA-authorized for veterinary use in EU.
> Alias Index
- Chemical identity: Spinosyns A + D mixture
- CAS Number: 168316-95-8
- Formula: C₄₁H₆₅NO₁₀ (spinosyn A, MW 731.96)
- Brand names: Comfortis (vet flea), Trifexis (vet flea+heartworm), Natroba (human head lice)
- Source: Saccharopolyspora spinosa fermentation
- Commercial request terms: spinosad API, Comfortis generic, veterinary flea treatment, organic insecticide API, TCS Industries Limited
> FAQ
What is the difference between veterinary-grade and technical-grade Spinosad?
Veterinary pharmaceutical-grade Spinosad meets ICH Q3C residual solvent limits and tighter purity specifications for oral dosage forms in companion animals. Technical-grade material is manufactured for agricultural insecticide formulations with different impurity profiles. Specify the intended application (veterinary or agricultural) at inquiry.
What documents are available for Spinosad orders?
COA and MSDS are standard for commercial discussions. COO, packing list, invoice and other import-support documents can be arranged according to order scope.
Do you supply Spinosad to Australia and Canada?
Yes. We support B2B buyers in Australia, New Zealand, Canada and South Korea, subject to route and document review.
Do you supply New Zealand and South Korea?
Yes. We review Australia, New Zealand, Canada and South Korea for project supply, import documents, packaging and logistics planning before quotation.
Is Spinosad approved for organic farming?
Yes. Spinosad is OMRI-listed (Organic Materials Review Institute) and approved for organic crop production under USDA National Organic Program and EU organic farming regulations. It is one of few insecticides permitted in organic agriculture due to its natural fermentation origin and favorable environmental profile.
How fast does Spinosad kill fleas in dogs?
Spinosad begins killing fleas within 30 minutes of oral administration and achieves >98% flea kill within 4 hours. This rapid onset is faster than most topical flea treatments. Monthly dosing at 30–60 mg/kg maintains protection. The API is formulated into flavored chewable tablets for palatability.
Can you arrange samples before commercial purchasing?
Samples or evaluation quantities may be reviewed for qualified buyers after target specification, application and destination-market requirements are clarified.
How is Spinosad packaged for export?
Packaging is confirmed by quantity and material properties. Typical options include foil bags, HDPE containers, fibre drums, 25 kg bags or palletized export packaging.
Can buyer-defined specifications be reviewed?
Yes. Send the specification, methods, impurity limits and required documents. TCS can review feasibility before confirming quotation and lead time.
What payment terms are normally used?
Standard payment is 100% T/T before dispatch unless a different arrangement has been approved for an established commercial account.
What lead time should buyers expect?
Lead time depends on stock, batch size, document scope and destination. Available stock can move faster; made-to-order or pallet programs require longer planning.
What is the spinosyn A:D ratio in Spinosad?
Spinosad is a defined mixture of spinosyn A (major component, approximately 85%) and spinosyn D (approximately 15%). Both are macrocyclic lactones produced by Saccharopolyspora spinosa. The A:D ratio is controlled during fermentation and purification and is specified on the COA.
Last reviewed: June 2026
> Request a Quote
If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.