TCS Industries Limited (China-sourced API supplier) supplies Latanoprost — API CAS 130209-82-4 for pharmaceutical B2B procurement — COA, MSDS, and technical documentation available on request.
> Overview
| Product Name | Latanoprost |
|---|---|
| Structural Formula |  |
| CAS Number | 130209-82-4 |
| Molecular Formula | C26H40O5 |
| Molecular Weight | 432.6 g/mol |
| InChIKey | GGXICVAJURFBLW-CEYXHVGTSA-N |
| SMILES | Available on request where applicable |
| Appearance | Colourless to slightly yellowish oily liquid |
| Purity / Grade | By agreed specification and batch COA |
| Storage | Store unopened at 2–8°C; in use at up to 25°C for up to 4 weeks |
Latanoprost (CAS 130209-82-4) is a prostaglandin F₂α analog prodrug with the formula C₂₆H₄₀O₅ (MW 432.58). The isopropyl ester prodrug is hydrolyzed by corneal esterases to the active acid form, which selectively activates the prostaglandin FP receptor. Latanoprost is used for open-angle glaucoma and ocular hypertension and is on the WHO Model List of Essential Medicines.
TCS Industries Limited, a Hong Kong-based trading and sourcing company, supplies Latanoprost API in pharmaceutical grade for global procurement programs.
> Applications
First-line glaucoma therapy
Latanoprost ophthalmic solution 0.005% is instilled once daily (evening) to reduce IOP by 25–35%. It lowers IOP primarily by increasing uveoscleral outflow of aqueous humor. Latanoprost is a widely prescribed first-line IOP-lowering agent. Camras et al. (Ophthalmology, 1996, 103:1916–1924) established the efficacy and safety of latanoprost 0.005% once daily, demonstrating superior IOP reduction compared to timolol 0.5% twice daily in open-angle glaucoma patients.
Combination formulations
Latanoprost is available in fixed-dose combinations with timolol (Xalacom), netarsudil (Rocklatan), and other IOP-lowering agents. These combinations provide additive IOP reduction through complementary mechanisms while maintaining once-daily dosing convenience.
> Sourcing & Supply
TCS Industries Limited supports development, qualification and commercial purchasing discussions for Latanoprost with buyers in Australia, New Zealand, Canada and South Korea.
- Evaluation and commercial quantities: 10 g samples for analytical qualification; 100 g and 500 g for production. Pharmaceutical-grade oily liquid or crystalline forms available. DMF reference letters provided.
- Pallet quantities and production campaigns: repeat supply is coordinated against packaging, lead time, annual demand and destination-market import requirements.
> Quality & Documentation
Key specification parameters include assay (≥98.0%), related substances (latanoprost acid, 15-epi-latanoprost), optical rotation, water content, residual solvents, heavy metals, and microbial limits. colourless to slightly yellowish oily liquid. Soluble in acetonitrile and ethanol, practically insoluble in water. Identity by HPLC and IR. Meets in-house pharmaceutical specifications. COA, MSDS, and stability data are standard.
> Packaging
Latanoprost is a colourless to slightly yellowish oily liquid at room temperature. Thermally sensitive — store at -20 °C to 2–8 °C. Standard packaging includes sealed amber glass bottles or vials under nitrogen (10 g, 50 g, or 100 g). Protect from light. Cold chain shipment required. Shelf life is typically 24 months at -20 °C. Labels and documents are checked before dispatch.
> Pricing & MOQ
Pricing is quoted by specification, packaging and destination. Common commercial discussions use 25 kg bag/drum formats, pallet quantities and production-campaign planning; smaller samples may be reviewed for qualified formulation teams.
> Regulatory & Compounding Context
Latanoprost was FDA-approved in 1996 (Xalatan, Pfizer). EMA-authorized. On the WHO Model List of Essential Medicines. Off-patent with multiple generic approvals. Listed in the FDA IID for ophthalmic dosage forms. DMF support available from qualified manufacturers.
> Alias Index
- INN: Latanoprost
- CAS Number: 130209-82-4
- Formula: C₂₆H₄₀O₅ (MW 432.58)
- Brand name: Xalatan (Pfizer)
- ATC code: S01EE01
- Active metabolite: Latanoprost acid (free acid)
- Commercial request terms: latanoprost API, Xalatan generic, prostaglandin analog glaucoma, FP receptor agonist, TCS Industries Limited
> FAQ
Why is Latanoprost a prodrug?
The isopropyl ester form has better corneal penetration than the active acid. Corneal esterases hydrolyze the ester during absorption, releasing latanoprost acid in the anterior chamber. This prodrug strategy achieves higher intraocular drug levels with lower topical concentrations, reducing surface exposure and systemic absorption.
What documents are available for Latanoprost orders?
COA and MSDS are standard for commercial discussions. COO, packing list, invoice and other import-support documents can be arranged according to order scope.
Do you supply Latanoprost to Australia and Canada?
Yes. We support B2B buyers in Australia, New Zealand, Canada and South Korea, subject to route and document review.
Do you supply New Zealand and South Korea?
Yes. We review Australia, New Zealand, Canada and South Korea for project supply, import documents, packaging and logistics planning before quotation.
Why must it be stored cold?
Latanoprost is susceptible to hydrolysis and isomerization at elevated temperatures. API must be stored at -20 °C. Unopened commercial drops (Xalatan) should be refrigerated. Once opened, the multidose bottle may be stored at room temperature for up to 6 weeks. Preservative-free unit-dose formulations avoid the room-temperature stability concern.
What iris colour change risk exists?
Latanoprost (and all prostaglandin analogs) can increase melanin production in iris melanocytes, causing irreversible brown pigmentation of hazel, green, or blue-brown irides. Risk is ~33% over 5 years in mixed-colour irides. Brown irides are rarely affected. This is a cosmetic change without clinical significance.
Can you arrange samples before commercial purchasing?
Samples or evaluation quantities may be reviewed for qualified buyers after target specification, application and destination-market requirements are clarified.
How is Latanoprost packaged for export?
Packaging is confirmed by quantity and material properties. Typical options include foil bags, HDPE containers, fibre drums, 25 kg bags or palletized export packaging.
Can buyer-defined specifications be reviewed?
Yes. Send the specification, methods, impurity limits and required documents. TCS can review feasibility before confirming quotation and lead time.
What payment terms are normally used?
Standard payment is 100% T/T before dispatch unless a different arrangement has been approved for an established commercial account.
What lead time should buyers expect?
Lead time depends on stock, batch size, document scope and destination. Available stock can move faster; made-to-order or pallet programs require longer planning.
Is a DMF available?
Yes. TCS sources latanoprost from manufacturers who maintain active DMFs with the FDA and equivalent regulatory submissions with EMA. Off-patent with extensive generic competition. COA, stability data, and DMF reference letters are provided for ANDA and generic ophthalmic formulation support.
Last reviewed: June 2026
Evaluation and research orders (≤10 kg) are shipped with COA, MSDS, and certificate of origin. Bulk commercial orders (>10 kg) qualify for volume pricing with a full technical documentation package available on request.
> Request a Quote
If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.