Fenofibrate (CAS 49562-28-9) is a fibric acid derivative used in the management of hypertriglyceridemia and mixed dyslipidemia. It is a prodrug that is rapidly converted in vivo to fenofibric acid, which activates peroxisome proliferator-activated receptor alpha (PPARα). Activation of PPARα enhances lipolysis and clearance of triglyceride-rich lipoproteins, while also modulating HDL and LDL fractions, leading to improved lipid profiles.
Fenofibrate 49562-28-9 from TCS GROUP is supplied as a high-quality API for oral solid dosage forms, including tablets and capsules. Fenofibrate is often prescribed to reduce triglycerides and, in some patients, increase HDL cholesterol, particularly in individuals with metabolic syndrome or type 2 diabetes. LiverTox and other references note that fenofibrate therapy is generally well tolerated but can occasionally cause elevations in liver enzymes or rare serious liver injury, so liver function monitoring is recommended.
As a lipophilic, poorly water-soluble compound, fenofibrate poses formulation challenges. Strategies such as micronisation, solid dispersions and specialised particle engineering are commonly used to enhance dissolution and bioavailability. TCS INDUSTRIES LIMITED supports partners with technical documentation and may supply complementary Pharmaceutical Excipients that assist in these tasks.
In cardiometabolic portfolios, fenofibrate is often positioned alongside other chronic-care APIs supplied by TCS GROUP, such as:
- Atenolol 29122-68-7 – a cardioselective β₁-blocker used for hypertension and angina.
- Benazepril 86541-75-5 – an ACE inhibitor indicated for hypertension and heart failure.
- Coenzyme Q10 303-98-0 – a mitochondrial cofactor and antioxidant frequently included in supplements aimed at cardiovascular support and statin-associated fatigue.
Placing these APIs under the common umbrella of the
Active Pharmaceutical Ingredient
category enables companies to create integrated lipid- and risk-management product lines, while simplifying vendor qualification and documentation control.
By sourcing Fenofibrate 49562-28-9 from TCS INDUSTRIES LIMITED, manufacturers gain a proven fibrate lipid-lowering API with full technical support, aligning chemical quality, regulatory requirements and commercial reliability.