Croscarmellose sodium (CCS) is a cross-linked polymer of sodium carboxymethyl cellulose developed as a high-efficiency superdisintegrant for oral solid dosage forms. Its fibrous, cross-linked structure makes it insoluble yet highly hydrophilic, allowing it to swell rapidly and draw water into the tablet matrix, which causes fast breakup of tablets and capsules at low use levels.
At TCS INDUSTRIES LIMITED,
Croscarmellose Sodium – Superdisintegrant for Rapid Tablet Disintegration
is offered in grades designed for direct compression, wet granulation, roller compaction and capsule filling. When a tablet containing CCS contacts aqueous media, the excipient swells in multiple directions and wicks water throughout the compact, rapidly disrupting bonds between particles and accelerating disintegration. This behaviour supports improved drug dissolution and bioavailability in immediate-release formulations.
Croscarmellose sodium can be used alone or in combination with other superdisintegrants and fillers from the TCS portfolio, such as:
- Crospovidone – Cross-Linked PVP Superdisintegrant & Stabilizer – an insoluble cross-linked PVP that provides rapid disintegration via wicking without gelling, often used in synergy with CCS for challenging APIs.
- Calcium Hydrogen Phosphate Dihydrate – DCPD Filler & Mineral Source – a widely used filler that offers good compressibility; CCS helps ensure fast disintegration even at higher mineral loads.
- Colloidal Silicon Dioxide – Glidant, Anti-Caking Agent & Adsorbent – improves flow and reduces capping in high-speed manufacturing while CCS delivers rapid breakup.
Typical CCS inclusion levels are in the 0.5–5% w/w range, depending on formulation and process. Over-lubrication or excessive compression force can slow disintegration, so it is important to optimise lubricant type and tablet hardness. TCS GROUP offers technical support to help formulators fine-tune these parameters across both generic and innovative products.
By choosing Croscarmellose Sodium from TCS INDUSTRIES LIMITED, manufacturers gain a reliable, well-characterised superdisintegrant that shortens disintegration time, supports robust bioavailability and fits seamlessly into modern high-speed tablet production.