TCS Industries Limited (China-sourced API supplier) supplies Crospovidone – -Cross-Linked PVP Superdisintegrant & Stabilizer CAS 25249-54-1 for pharmaceutical B2B procurement — COA, MSDS, and technical documentation available on request.
> Overview
| Product Name | Crospovidone – -Cross-Linked PVP Superdisintegrant & Stabilizer |
|---|---|
| Structural Formula |  |
| CAS Number | 25249-54-1 |
| Molecular Formula | (C6H9NO)n (cross-linked PVP) |
| Molecular Weight | Cross-linked polymer (MW >1,000,000) |
| InChIKey | Not applicable (cross-linked polymer) |
| SMILES | Available on request where applicable |
| Appearance | White to off-white, free-flowing powder |
| Purity / Grade | By agreed specification and batch COA |
| Storage | Keep tightly closed in a cool, dry, well-ventilated place |
Crospovidone (CAS 25249-54-1, also known as PVPP or polyvinylpolypyrrolidone) is a cross-linked homopolymer of N-vinyl-2-pyrrolidone used as a super-disintegrant in tablet and capsule formulations. Unlike croscarmellose sodium which swells, crospovidone functions primarily by wicking (capillary water uptake) and elastic strain recovery, returning to its pre-compression shape and mechanically disrupting the tablet matrix.
TCS Industries Limited, a Hong Kong-based trading and sourcing company, supplies Crospovidone in pharmaceutical grade (NF/Ph.Eur.) for global procurement programs.
> Applications
Super-disintegrant for tablets and capsules
Crospovidone is used at 2–5% in tablet formulations as a disintegrant. It is particularly effective in directly compressed, low-porosity tablets where its elastic recovery mechanism provides rapid mechanical disruption. Crospovidone produces lower friability than swelling-type disintegrants. Kolter et al. (AAPS PharmSciTech, 2010, 11:1572–1578) evaluated the disintegrant performance of crospovidone across different particle sizes and compression forces in direct compression tablets.
Adsorbent and clarifying agent
In pharmaceutical manufacturing, crospovidone adsorbs dissolved impurities and colored substances. In the beverage industry (PVPP), it is used as a clarifying and stabilizing agent in beer and wine to adsorb polyphenols that cause haze formation. This is a non-pharmaceutical but commercially significant application.
> Sourcing & Supply
TCS Industries Limited supports development, qualification and commercial purchasing discussions for Crospovidone – -Cross-Linked PVP Superdisintegrant & Stabilizer with buyers in South America, Europe, the United Kingdom, Australia, New Zealand, Mexico and Canada.
- Evaluation and commercial quantities: 5 kg samples for formulation trials; 25 kg drums for production. Pharmaceutical grade (NF/Ph.Eur.) in coarse and fine particle sizes available.
- Pallet quantities and production campaigns: repeat supply is coordinated against packaging, lead time, annual demand and destination-market import requirements.
> Quality & Documentation
Key specification parameters include nitrogen content (11.0–12.8%), water-soluble substances (≤1.5%), loss on drying (≤5.0%), pH (5.0–8.0), heavy metals (Pb ≤10 ppm), peroxide, particle size (coarse and fine grades), and microbial limits. White to off-white, free-flowing, compressible powder. Available in coarse (100–130 µm) and fine (20–40 µm) particle sizes. Meets NF, Ph.Eur. (Crospovidonum), and JP. COA and MSDS are standard.
> Packaging
Crospovidone is a white to off-white, free-flowing powder. Slightly hygroscopic. Standard packaging includes 25 kg fibre drums with PE liner. Store at room temperature (15–25 °C) in dry conditions. Shelf life is typically 36 months. Labels and documents are checked before dispatch.
> Pricing & MOQ
Pricing is quoted by specification, packaging and destination. Common commercial discussions use 25 kg bag/drum formats, pallet quantities and production-campaign planning; smaller samples may be reviewed for qualified formulation teams.
> Regulatory & Compounding Context
Crospovidone is monographed in NF (Crospovidone), Ph.Eur. (Crospovidonum), and JP. Listed in the FDA IID for oral dosage forms. PVPP is approved for beverage clarification in the EU and US (21 CFR 173.50). No special import permits for pharmaceutical-grade material.
> Alias Index
- Chemical class: Cross-linked poly(N-vinyl-2-pyrrolidone)
- CAS Number: 25249-54-1
- Abbreviation: PVPP (polyvinylpolypyrrolidone)
- Pharmacopoeial name: Crospovidonum (Ph.Eur.)
- Brand equivalents: Kollidon CL, Kollidon CL-F (BASF), Polyplasdone XL (ISP/Ashland)
- Related materials: Povidone (soluble PVP), Copovidone
- Commercial request terms: crospovidone NF, PVPP pharma grade, Kollidon CL equivalent, super-disintegrant, TCS Industries Limited
> FAQ
What is the difference between coarse and fine Crospovidone?
Coarse grade (~100–130 µm, Kollidon CL/Polyplasdone XL equivalent) is preferred for direct compression — better flow and less effect on tablet hardness. Fine grade (~20–40 µm, Kollidon CL-F equivalent) is preferred for wet granulation and when rapid disintegration of small tablets is needed. Specify particle size at inquiry.
What documents are available for Crospovidone – -Cross-Linked PVP Superdisintegrant & Stabilizer orders?
COA and MSDS are standard for commercial discussions. COO, packing list, invoice and other import-support documents can be arranged according to order scope.
Can TCS Industries Limited support Crospovidone – -Cross-Linked PVP Superdisintegrant & Stabilizer supply to South America?
Yes. We support B2B buyers in Argentina, Colombia, Chile, Peru, Ecuador, Uruguay, Bolivia, Brazil, Paraguay, Venezuela, Guyana and Suriname, subject to route and document review.
Do you support Europe, the United Kingdom, Australia, New Zealand, Mexico and Canada?
Yes. These destinations can be reviewed for project supply, import documents, packaging and logistics planning before quotation.
How does Crospovidone differ from Povidone?
Povidone (PVP) is a soluble linear polymer used as a tablet binder and viscosity modifier. Crospovidone (PVPP) is a cross-linked, water-insoluble form used as a disintegrant. They share the same monomer (N-vinyl-2-pyrrolidone) but have opposite functions: povidone binds tablets together, crospovidone breaks them apart.
Does Crospovidone swell like Croscarmellose?
No. Crospovidone does not swell significantly in water. Its disintegrant action comes from: (1) wicking — rapid capillary uptake of water into the tablet matrix; (2) strain recovery — the compressed particles return to their original shape, generating mechanical stress that fractures the tablet. This non-swelling mechanism makes it suitable for formulations where swelling is undesirable.
Can you arrange samples before commercial purchasing?
Samples or evaluation quantities may be reviewed for qualified buyers after target specification, application and destination-market requirements are clarified.
How is Crospovidone – -Cross-Linked PVP Superdisintegrant & Stabilizer packaged for export?
Packaging is confirmed by quantity and material properties. Typical options include foil bags, HDPE containers, fibre drums, 25 kg bags or palletized export packaging.
Can buyer-defined specifications be reviewed?
Yes. Send the specification, methods, impurity limits and required documents. TCS can review feasibility before confirming quotation and lead time.
What payment terms are normally used?
Standard payment is 100% T/T before dispatch unless a different arrangement has been approved for an established commercial account.
What lead time should buyers expect?
Lead time depends on stock, batch size, document scope and destination. Available stock can move faster; made-to-order or pallet programs require longer planning.
Is Crospovidone compatible with moisture-sensitive APIs?
Crospovidone absorbs significantly less moisture than croscarmellose sodium or sodium starch glycolate. It is preferred for moisture-sensitive API formulations. However, it can adsorb certain dissolved drug substances — perform drug-excipient compatibility studies, particularly with weakly basic APIs.
Last reviewed: June 2026
Evaluation and research orders (≤10 kg) are shipped with COA, MSDS, and certificate of origin. Bulk commercial orders (>10 kg) qualify for volume pricing with a full technical documentation package available on request.
> Request a Quote
If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.