Crospovidone: Cross-Linked PVP Superdisintegrant
Crospovidone (cross-linked polyvinylpyrrolidone, PVPP) is a synthetic superdisintegrant that acts primarily through a wicking and capillary mechanism rather than swelling. It is insoluble in water despite being derived from polyvinylpyrrolidone, and its porous, compressible particle structure makes it highly effective at promoting rapid tablet disintegration.
Product Profile
| CAS Number | 25249-54-1 |
|---|---|
| Appearance | White to off-white, free-flowing powder |
| Function | Superdisintegrant / dissolution enhancer |
| Typical Use Level | 2–5% w/w |
| Compendial Grade | EP / USP-NF / JP |
Formulation Applications
Crospovidone is valued for its rapid wicking action — it draws water into the tablet through capillary channels without forming a viscous gel layer, which distinguishes it from sodium starch glycolate. This makes it particularly effective in orally disintegrating tablets (ODTs) where sub-30-second disintegration is targeted. It is available in different particle sizes: standard grades for conventional tablets and ultrafine grades for ODTs. Crospovidone also has polyphenol-binding properties and is used in the beverage industry (as PVPP) for clarification of beer and wine. In pharmaceutical use, it shows minimal tendency toward over-lubrication effects and is compatible with most excipient systems.
Why Source from TCS
TCS supplies crospovidone in pharmaceutical grade to formulators across Europe. Multiple particle size grades available with flexible quantities for R&D through production scale. Contact us with your application and volume requirements.
FAQ
What information should be included in an inquiry for Crospovidone – 25249-54-1?
A useful inquiry normally includes the product name, target application, estimated quantity, destination market, and any specific documentation or packaging requests.
How is Crospovidone – 25249-54-1 usually evaluated for sourcing?
This product is positioned for excipient sourcing where formulation fit, dosage form, handling, and repeat purchasing requirements need to be reviewed together with commercial supply conditions.
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For excipient sourcing, teams usually discuss the intended dosage form, formulation role, packaging format, order volume, and the routine documentation needed for qualification and purchasing.
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