TCS Industries Limited (China-sourced API supplier) supplies Crotamiton –- Topical Antipruritic & Scabicidal Agent CAS 483-63-6 for pharmaceutical B2B procurement — COA, MSDS, and technical documentation available on request.
> Overview
| Product Name | Crotamiton –- Topical Antipruritic & Scabicidal Agent |
|---|---|
| Structural Formula |  |
| CAS Number | 483-63-6 |
| Molecular Formula | C₁₃H₁₇NO |
| Molecular Weight | 203.28 g/mol |
| InChIKey | DNTGGZPQPQTDQF-UHFFFAOYSA-N |
| SMILES | Available on request where applicable |
| Appearance | Colourless to pale yellow oily liquid |
| Purity / Grade | By agreed specification and batch COA |
| Storage | Keep tightly closed in a cool, dry, well-ventilated place |
Crotamiton (CAS 483-63-6) is an antipruritic and scabicidal agent with the formula C₁₃H₁₇NO (MW 203.28). It is the active ingredient in Eurax cream and lotion, used topically for the treatment of scabies (Sarcoptes scabiei infestation) and symptomatic relief of pruritus. Crotamiton is a colourless to pale yellow oily liquid with a faint amine odor.
TCS Industries Limited, a Hong Kong-based trading and sourcing company, supplies Crotamiton as an API for pharmaceutical manufacturing and topical formulation programs.
> Applications
Scabicidal topical treatment
Crotamiton 10% cream or lotion is applied topically for scabies treatment (two applications 24 hours apart, washed off 48 hours after the second application). Its scabicidal mechanism involves direct toxicity to the mite. It is considered a second-line treatment after permethrin 5% cream. Strong et al. (Cochrane Database Syst Rev, 2007, 3:CD000320) reviewed the evidence for topical scabicides including crotamiton compared to permethrin and ivermectin.
Antipruritic for symptomatic itch relief
Crotamiton has independent antipruritic activity unrelated to its scabicidal effect. It is used in 10% cream formulations for symptomatic relief of pruritus associated with dermatoses, insect bites, and dry skin conditions. The antipruritic mechanism is not fully elucidated but may involve sensory nerve modulation.
> Sourcing & Supply
TCS Industries Limited supports development, qualification and commercial purchasing discussions for Crotamiton –- Topical Antipruritic & Scabicidal Agent with buyers in South America, Europe, the United Kingdom, Australia, New Zealand, Mexico and Canada.
- Evaluation and commercial quantities: 1 kg samples for formulation trials; 25 kg drums for production. Pharmaceutical API grade (USP/Ph.Eur.) available.
- Pallet quantities and production campaigns: repeat supply is coordinated against packaging, lead time, annual demand and destination-market import requirements.
> Quality & Documentation
Key specification parameters include assay (≥97.0% crotamiton by GC), trans-crotamiton isomer content, related substances (crotonic acid, N-ethyl-o-toluidine), residual solvents, water content, refractive index (1.540–1.542), specific gravity, colour, and microbial limits. colourless to pale yellow oily liquid. Identity by IR and GC retention time. COA and MSDS are standard.
> Packaging
Crotamiton is a liquid API, sensitive to light. Standard packaging includes 25 kg or 50 kg HDPE drums, tightly sealed and light-protected. Store at controlled room temperature (15–25 °C) protected from light. Shelf life is typically 24 months. Labels and documents are checked before dispatch.
> Pricing & MOQ
Pricing is quoted by specification, packaging and destination. Common commercial discussions use 25 kg bag/drum formats, pallet quantities and production-campaign planning; smaller samples may be reviewed for qualified formulation teams.
> Regulatory & Compounding Context
Crotamiton is monographed in USP-NF, Ph.Eur. (Crotamitonum), BP, and JP. Listed in the FDA IID for topical dosage forms. Prescription or OTC status varies by jurisdiction. On the WHO Model List of Essential Medicines (complementary list, scabicide). No special import permits for API material in most markets.
> Alias Index
- IUPAC: N-Ethyl-N-(2-methylphenyl)but-2-enamide
- CAS Number: 483-63-6
- Formula: C₁₃H₁₇NO (MW 203.28)
- INN: Crotamiton
- Brand name: Eurax (GSK)
- InChIKey: DNTGGZPQPQTDQF-UHFFFAOYSA-N
- Commercial request terms: crotamiton API USP, scabicide active ingredient, Eurax API, antipruritic pharma, TCS Industries Limited
> FAQ
Is Crotamiton effective against scabies?
Crotamiton 10% is a recognized scabicide, though cure rates (60–80%) are lower than permethrin 5% (90–95%) in clinical trials. It is used as a second-line option when permethrin is unavailable, contraindicated, or in cases of permethrin resistance. Multiple applications over 2–5 days may improve efficacy.
What documents are available for Crotamiton –- Topical Antipruritic & Scabicidal Agent orders?
COA and MSDS are standard for commercial discussions. COO, packing list, invoice and other import-support documents can be arranged according to order scope.
Can TCS Industries Limited support Crotamiton –- Topical Antipruritic & Scabicidal Agent supply to South America?
Yes. We support B2B buyers in Argentina, Colombia, Chile, Peru, Ecuador, Uruguay, Bolivia, Brazil, Paraguay, Venezuela, Guyana and Suriname, subject to route and document review.
Do you support Europe, the United Kingdom, Australia, New Zealand, Mexico and Canada?
Yes. These destinations can be reviewed for project supply, import documents, packaging and logistics planning before quotation.
What formulations use Crotamiton?
Crotamiton is formulated as 10% cream and 10% lotion for topical application. It is a liquid API and dissolves readily in typical cream bases (oil-in-water emulsions). No solid dosage forms are manufactured. Specify cream or lotion base requirements at inquiry.
Is Crotamiton on the WHO Essential Medicines List?
Yes. Crotamiton is on the WHO Model List of Essential Medicines (complementary list) as a scabicide. This designation applies to 10% topical preparations. Permethrin 5% cream is on the core list as the first-line agent.
Can you arrange samples before commercial purchasing?
Samples or evaluation quantities may be reviewed for qualified buyers after target specification, application and destination-market requirements are clarified.
How is Crotamiton –- Topical Antipruritic & Scabicidal Agent packaged for export?
Packaging is confirmed by quantity and material properties. Typical options include foil bags, HDPE containers, fibre drums, 25 kg bags or palletized export packaging.
Can buyer-defined specifications be reviewed?
Yes. Send the specification, methods, impurity limits and required documents. TCS can review feasibility before confirming quotation and lead time.
What payment terms are normally used?
Standard payment is 100% T/T before dispatch unless a different arrangement has been approved for an established commercial account.
What lead time should buyers expect?
Lead time depends on stock, batch size, document scope and destination. Available stock can move faster; made-to-order or pallet programs require longer planning.
What is the shelf life of Crotamiton API?
Crotamiton API has a typical shelf life of 24 months when stored at 15–25 °C, protected from light, in tightly sealed HDPE drums. The trans/cis isomer ratio and related substances should be monitored. Retest date and storage conditions are stated on the COA.
Last reviewed: June 2026
Evaluation and research orders (≤10 kg) are shipped with COA, MSDS, and certificate of origin. Bulk commercial orders (>10 kg) qualify for volume pricing with a full technical documentation package available on request.
> Request a Quote
If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.