Crotamiton: Topical Antipruritic and Scabicidal Agent
Crotamiton is a topical agent with both antipruritic (anti-itch) and scabicidal properties. It is used in the treatment of scabies (Sarcoptes scabiei infestation) and for symptomatic relief of pruritus associated with various dermatological conditions. Unlike permethrin or lindane, crotamiton provides concurrent itch relief alongside its acaricidal action.
Product Profile
| CAS Number | 483-63-6 |
|---|---|
| Molecular Formula | C₁₃H₁₇NO |
| Appearance | Colourless to slightly yellowish oily liquid |
| Function | Antipruritic / scabicidal active |
| Typical Use Level | 10% in creams and lotions |
Formulation Applications
Crotamiton is typically formulated as a 10% cream or lotion for topical application. For scabies treatment, it is applied to the entire body from the chin down, usually on two consecutive nights with a cleansing bath 48 hours after the last application. As an antipruritic, it provides relief from itching caused by contact dermatitis, insect bites, and other minor skin irritations. Its mechanism of antipruritic action is not fully elucidated but is thought to involve a local counterirritant effect. Crotamiton is generally well-tolerated, with occasional local irritation reported. It is considered an alternative treatment option when first-line scabicides are contraindicated.
Why Source from TCS
TCS supplies crotamiton to pharmaceutical companies across Europe. Available with flexible quantities from development samples to commercial volumes. Contact us with your target market and project requirements for a tailored quotation.
FAQ
What information should be included in an inquiry for Crotamiton –483-63-6?
A useful inquiry normally includes the product name, target application, estimated quantity, destination market, and any specific documentation or packaging requests.
How is Crotamiton –483-63-6 usually evaluated for sourcing?
This product is positioned for excipient sourcing where formulation fit, dosage form, handling, and repeat purchasing requirements need to be reviewed together with commercial supply conditions.
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For excipient sourcing, teams usually discuss the intended dosage form, formulation role, packaging format, order volume, and the routine documentation needed for qualification and purchasing.
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