TCS Industries Limited (China-sourced API supplier) supplies Croscarmellose Sodium –- Superdisintegrant for Rapid Tablet Disintegration CAS 74811-65-7 for pharmaceutical B2B procurement — COA, MSDS, and technical documentation available on request.
> Overview
| Product Name | Croscarmellose Sodium –- Superdisintegrant for Rapid Tablet Disintegration |
|---|---|
| Structural Formula |  |
| CAS Number | 74811-65-7 |
| Molecular Formula | Cross-linked sodium carboxymethylcellulose |
| Molecular Weight | Cross-linked polymer (MW not applicable) |
| InChIKey | Not applicable (cross-linked polymer) |
| SMILES | Available on request where applicable |
| Appearance | White to off-white, free-flowing powder |
| Purity / Grade | By agreed specification and batch COA |
| Storage | Keep tightly closed in a cool, dry, well-ventilated place |
Croscarmellose Sodium (CAS 74811-65-7) is a cross-linked sodium carboxymethylcellulose polymer used as a super-disintegrant in tablet and capsule formulations. It swells rapidly (4–8 times its original volume) on contact with water, disrupting tablet structure and promoting drug dissolution. Croscarmellose sodium is one of three primary super-disintegrants used in modern pharmaceutical tableting, alongside crospovidone and sodium starch glycolate.
TCS Industries Limited, a Hong Kong-based trading and sourcing company, supplies Croscarmellose Sodium in pharmaceutical grade (NF/Ph.Eur.) for global procurement programs.
> Applications
Super-disintegrant in tablet and capsule formulations
Croscarmellose sodium is used at 1–5% concentration in tablet formulations (direct compression and wet granulation) as an intragranular and/or extragranular disintegrant. It functions by swelling and wicking mechanisms: rapid water absorption causes volume expansion that breaks apart the tablet matrix. It is effective at lower concentrations than starch-based disintegrants. Zhao et al. (J Pharm Sci, 2005, 94:1079–1089) investigated the disintegration mechanisms of croscarmellose sodium in tablet formulations using texture analysis and water uptake measurements.
Capsule disintegrant
In hard gelatin and HPMC capsule formulations, croscarmellose sodium at 3–5% promotes rapid disintegration of the capsule fill, particularly when the fill is a compacted plug or granulated powder that would otherwise dissolve slowly without a disintegrant.
> Sourcing & Supply
TCS Industries Limited supports development, qualification and commercial purchasing discussions for Croscarmellose Sodium –- Superdisintegrant for Rapid Tablet Disintegration with buyers in South America, Europe, the United Kingdom, Australia, New Zealand, Mexico and Canada.
- Evaluation and commercial quantities: 5 kg samples for formulation trials; 25 kg drums for production. Pharmaceutical grade (NF/Ph.Eur.) available.
- Pallet quantities and production campaigns: repeat supply is coordinated against packaging, lead time, annual demand and destination-market import requirements.
> Quality & Documentation
Key specification parameters include sodium content (6.0–8.5%), degree of cross-linking (defined by sodium chloride content ≤0.5% and degree of substitution 0.60–0.85), pH (5.0–7.0), loss on drying (≤10.0%), water-soluble substances (≤10.0%), heavy metals (Pb ≤10 ppm), settling volume (≥20 mL/g), and microbial limits. White to off-white fibrous powder. Meets NF, Ph.Eur. (Carmellosum natricum conexum), and JP. COA and MSDS are standard.
> Packaging
Croscarmellose sodium is a white to off-white fibrous powder, hygroscopic. Standard packaging includes 25 kg fibre drums with double PE liner. Store at room temperature in dry conditions (≤65% RH). Shelf life is typically 36 months. Labels and documents are checked before dispatch.
> Pricing & MOQ
Pricing is quoted by specification, packaging and destination. Common commercial discussions use 25 kg bag/drum formats, pallet quantities and production-campaign planning; smaller samples may be reviewed for qualified formulation teams.
> Regulatory & Compounding Context
Croscarmellose sodium is monographed in NF (Croscarmellose Sodium), Ph.Eur. (Carmellosum natricum conexum), and JP. Listed in the FDA IID for oral dosage forms. Not a food additive (pharmaceutical excipient only). No special import permits for pharmaceutical-grade material.
> Alias Index
- Chemical class: Cross-linked sodium carboxymethylcellulose
- CAS Number: 74811-65-7
- Abbreviation: CCS
- Pharmacopoeial name: Carmellosum natricum conexum (Ph.Eur.)
- Brand equivalents: Ac-Di-Sol (DuPont/IFF), Vivasol (JRS Pharma), Primellose (DFE Pharma)
- Related disintegrants: Crospovidone, Sodium starch glycolate
- Commercial request terms: croscarmellose sodium NF, Ac-Di-Sol equivalent, CCS super-disintegrant, tablet disintegrant pharma, TCS Industries Limited
> FAQ
What concentration of Croscarmellose Sodium is needed?
Typical concentration: 1–5% in tablet formulations. For direct compression: 2–3% extragranular. For wet granulation: 1–2% intragranular + 1–2% extragranular (split addition provides faster disintegration). Exceeding 5% can slow disintegration due to gel formation. Optimize concentration during formulation development.
What documents are available for Croscarmellose Sodium –- Superdisintegrant for Rapid Tablet Disintegration orders?
COA and MSDS are standard for commercial discussions. COO, packing list, invoice and other import-support documents can be arranged according to order scope.
Can TCS Industries Limited support Croscarmellose Sodium –- Superdisintegrant for Rapid Tablet Disintegration supply to South America?
Yes. We support B2B buyers in Argentina, Colombia, Chile, Peru, Ecuador, Uruguay, Bolivia, Brazil, Paraguay, Venezuela, Guyana and Suriname, subject to route and document review.
Do you support Europe, the United Kingdom, Australia, New Zealand, Mexico and Canada?
Yes. These destinations can be reviewed for project supply, import documents, packaging and logistics planning before quotation.
How does Croscarmellose differ from Crospovidone?
Both are super-disintegrants. Croscarmellose sodium (CCS) swells 4–8× and functions primarily by swelling. Crospovidone (PVPP) does not swell significantly and functions primarily by wicking (capillary action) and strain recovery. CCS is fibrous; crospovidone is granular. Choice depends on formulation compatibility and desired disintegration mechanism.
Is intragranular or extragranular addition better?
Split addition (intragranular + extragranular) provides the fastest disintegration. Intragranular CCS breaks apart granules into primary particles. Extragranular CCS breaks the tablet into granules. Using CCS only extragranularly may leave slow-dissolving granules intact. Split 50:50 or 1:2 (intra:extra) is the standard approach.
Can you arrange samples before commercial purchasing?
Samples or evaluation quantities may be reviewed for qualified buyers after target specification, application and destination-market requirements are clarified.
How is Croscarmellose Sodium –- Superdisintegrant for Rapid Tablet Disintegration packaged for export?
Packaging is confirmed by quantity and material properties. Typical options include foil bags, HDPE containers, fibre drums, 25 kg bags or palletized export packaging.
Can buyer-defined specifications be reviewed?
Yes. Send the specification, methods, impurity limits and required documents. TCS can review feasibility before confirming quotation and lead time.
What payment terms are normally used?
Standard payment is 100% T/T before dispatch unless a different arrangement has been approved for an established commercial account.
What lead time should buyers expect?
Lead time depends on stock, batch size, document scope and destination. Available stock can move faster; made-to-order or pallet programs require longer planning.
Does Croscarmellose Sodium affect drug stability?
CCS is hygroscopic (absorbs up to 60% its weight in water) which can affect moisture-sensitive APIs. It is pH-neutral (5.0–7.0) and chemically inert with most APIs. Perform compatibility studies with moisture-sensitive drugs. Store formulated products under controlled humidity conditions.
Last reviewed: June 2026
Evaluation and research orders (≤10 kg) are shipped with COA, MSDS, and certificate of origin. Bulk commercial orders (>10 kg) qualify for volume pricing with a full technical documentation package available on request.
> Request a Quote
If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.