TCS Industries Limited (China-sourced API supplier) supplies Selamectin — API CAS 220119-17-5 for pharmaceutical B2B procurement — COA, MSDS, and technical documentation available on request.
> Overview
| Product Name | Selamectin |
|---|---|
| Structural Formula |  |
| CAS Number | 220119-17-5 |
| Molecular Formula | C43H63NO11 |
| Molecular Weight | 770.0 g/mol |
| InChIKey | AFJYYKSVHJGXSN-XHKIUTQPSA-N |
| SMILES | Available on request where applicable |
| Appearance | White to yellowish crystalline powder |
| Purity / Grade | By agreed specification and batch COA |
| Storage | Store at controlled room temperature, protect from light |
Selamectin (CAS 220119-17-5) is a semi-synthetic avermectin antiparasitic with the formula C₄₃H₆₃NO₁₁ (MW 769.97). It is derived from doramectin by bioconversion. Selamectin potentiates glutamate-gated chloride channels and is unique among avermectins for its topical application and systemic absorption through the skin, providing concurrent endo- and ectoparasite control in companion animals.
TCS Industries Limited, a Hong Kong-based trading and sourcing company, supplies Selamectin API for veterinary topical (spot-on) formulation programs.
> Applications
Spot-on topical formulations for dogs and cats
Selamectin is formulated as a topical solution (Revolution / Stronghold, Zoetis) applied to the skin at the base of the neck. Standard dosing is 6 mg/kg monthly. The API is dissolved in isopropyl alcohol and dipropylene glycol methyl ether for rapid skin absorption and systemic distribution. Selamectin distributes into sebaceous glands, providing reservoir-based sustained release against ectoparasites. Six et al. (Vet Parasitol, 2000, 91:377–391) documented the efficacy of topical selamectin against multiple parasite species in dogs and cats.
Combination topical products
Selamectin is combined with sarolaner (Revolution Plus / Stronghold Plus) for enhanced efficacy against ticks and additional flea species. Combination spot-on formulations require vehicle optimization to ensure co-solubility and simultaneous percutaneous absorption of both actives without skin irritation.
> Sourcing & Supply
TCS Industries Limited supports development, qualification and commercial purchasing discussions for Selamectin with buyers in Australia, New Zealand, Canada and South Korea.
- Development and qualification quantities: 50 g to 5 kg packs for topical formulation development, stability studies, and veterinary drug registration submissions.
- Pallet quantities and production campaigns: repeat supply is coordinated against packaging, lead time, annual demand and destination-market import requirements.
> Quality & Documentation
Key specification parameters include assay (≥95.0%), related substances, specific optical rotation, water content, residual solvents, heavy metals, and microbial limits. White to yellowish crystalline powder. Practically insoluble in water, soluble in organic solvents. Identity by HPLC and UV. Meets in-house veterinary pharmaceutical specifications. COA and MSDS are standard.
> Packaging
Selamectin is a white to yellowish crystalline powder. Standard packaging includes sealed foil bags under nitrogen in fibre drums (50 g, 100 g, 500 g, or 1 kg). Store at controlled room temperature (15–25 °C). Protect from light. Shelf life is typically 36 months. Labels and documents are checked before dispatch.
> Pricing & MOQ
Pricing is quoted by specification, packaging and destination. Common commercial discussions use 25 kg bag/drum formats, pallet quantities and production-campaign planning; smaller samples may be reviewed for qualified formulation teams.
> Regulatory & Compounding Context
Selamectin is approved for veterinary use only. FDA-CVM approved in 1999 (Revolution, Zoetis). EMA-authorized (Stronghold). Revolution Plus (selamectin + sarolaner) approved for cats. Not approved for food-producing animals or human use. Generic selamectin products available in some markets.
> Alias Index
- INN: Selamectin
- CAS Number: 220119-17-5
- Formula: C₄₃H₆₃NO₁₁ (MW 769.97)
- Brand names: Revolution (US), Stronghold (EU), Revolution Plus (with sarolaner)
- ATCvet code: QP54AA05
- Source: Semi-synthetic from doramectin
- Commercial request terms: selamectin API, Revolution generic, topical endectocide, companion animal antiparasitic, TCS Industries Limited
> FAQ
What parasites does Selamectin protect against?
Selamectin provides coverage against heartworm (Dirofilaria immitis prevention), fleas (Ctenocephalides felis, C. canis), ear mites (Otodectes cynotis), sarcoptic mange (Sarcoptes scabiei), and intestinal roundworms and hookworms in cats. The spot-on application route provides monthly protection from a single dose.
What documents are available for Selamectin orders?
COA and MSDS are standard for commercial discussions. COO, packing list, invoice and other import-support documents can be arranged according to order scope.
Do you supply Selamectin to Australia and Canada?
Yes. We support B2B buyers in Australia, New Zealand, Canada and South Korea, subject to route and document review.
Do you supply New Zealand and South Korea?
Yes. We review Australia, New Zealand, Canada and South Korea for project supply, import documents, packaging and logistics planning before quotation.
Is Selamectin safe for ivermectin-sensitive breeds?
Selamectin has a wider safety margin than ivermectin in dogs with MDR1 (ABCB1) gene mutation (Collies, Australian Shepherds, Shetland Sheepdogs). It has been used at label doses in these breeds without the neurotoxicity associated with ivermectin. However, buyers should reference current safety data for their specific formulation and dose level.
How is Selamectin absorbed from topical application?
Selamectin applied to the skin at the base of the neck is absorbed transdermally and enters the systemic circulation. It accumulates in sebaceous glands, providing a sustained-release reservoir. This mechanism allows monthly dosing. Vehicle composition (isopropyl alcohol, dipropylene glycol methyl ether) affects absorption rate and bioavailability.
Can you arrange samples before commercial purchasing?
Samples or evaluation quantities may be reviewed for qualified buyers after target specification, application and destination-market requirements are clarified.
How is Selamectin packaged for export?
Packaging is confirmed by quantity and material properties. Typical options include foil bags, HDPE containers, fibre drums, 25 kg bags or palletized export packaging.
Can buyer-defined specifications be reviewed?
Yes. Send the specification, methods, impurity limits and required documents. TCS can review feasibility before confirming quotation and lead time.
What payment terms are normally used?
Standard payment is 100% T/T before dispatch unless a different arrangement has been approved for an established commercial account.
What lead time should buyers expect?
Lead time depends on stock, batch size, document scope and destination. Available stock can move faster; made-to-order or pallet programs require longer planning.
What is the difference between Selamectin and Ivermectin?
Selamectin (CAS 220119-17-5) is a semi-synthetic derivative of doramectin with an oxime modification. Ivermectin (CAS 70288-86-7) is derived from abamectin. Selamectin is formulated for topical spot-on use in companion animals; ivermectin is used as oral/injectable formulations in livestock and companion animals. Selamectin has a better safety profile in MDR1-mutant breeds.
Last reviewed: June 2026
Evaluation and research orders (≤10 kg) are shipped with COA, MSDS, and certificate of origin. Bulk commercial orders (>10 kg) qualify for volume pricing with a full technical documentation package available on request.
> Request a Quote
If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.