TCS Industries Limited (China-sourced API supplier) supplies Neotame — Plant Extract CAS 165450-17-9 for pharmaceutical B2B procurement — COA, MSDS, and technical documentation available on request.
> Overview
| Product Name | Neotame |
|---|---|
| Structural Formula |  |
| CAS Number | 165450-17-9 |
| Molecular Formula | C20H30N2O5 |
| Molecular Weight | 378.5 g/mol |
| InChIKey | HLIAVLHNDJUHFG-HOTGVXAUSA-N |
| SMILES | Available on request where applicable |
| Appearance | White to off-white crystalline powder |
| Purity / Grade | By agreed specification and batch COA |
| Storage | Keep tightly closed in a cool, dry, well-ventilated place |
Neotame (CAS 165450-17-9) is a dipeptide derivative high-intensity sweetener with the formula C₂₀H₃₀N₂O₅ (MW 378.46), approximately 7,000–13,000 times sweeter than sucrose. It is structurally related to aspartame but with a 3,3-dimethylbutyl group on the amino nitrogen, which makes it resistant to peptidase degradation and eliminates the phenylalanine labeling requirement. Neotame provides clean sweetness at extremely low use levels (mg/kg range).
TCS Industries Limited, a Hong Kong-based trading and sourcing company, supplies Neotame in food (FCC) and pharmaceutical grades for global procurement programs.
> Applications
Ultra-high-potency food sweetener
Neotame is used in beverages, dairy products, baked goods, tabletop sweeteners, and confectionery at concentrations of 5–50 mg/kg (providing equivalent sweetness to 8–12% sucrose). It is heat-stable (suitable for baking and pasteurization), stable across pH 3–7, and has a clean sweet taste without the metallic aftertaste of saccharin. Nofre et al. (Food Chem, 2000, 69:245–257) characterized the structure-sweetness relationship of neotame and related N-alkyl aspartame derivatives.
Animal feed flavoring and pharmaceutical taste-masking
Neotame is approved as a flavor enhancer in animal feed (EU, US) where its high potency provides cost-effective sweetening at very low inclusion rates. In pharmaceutical applications, it masks the bitter taste of APIs in oral formulations at concentrations 30–50 times lower than aspartame, minimizing formulation impact.
> Sourcing & Supply
TCS Industries Limited supports development, qualification and commercial purchasing discussions for Neotame with buyers in Germany, France, Italy, Spain, the United Kingdom, the United States, Canada and Australia.
- Evaluation and commercial quantities: 1 kg samples for formulation trials; 5 kg and 25 kg drums for production. Food grade (FCC/E961) available.
- Pallet quantities and production campaigns: repeat supply is coordinated against packaging, lead time, annual demand and destination-market import requirements.
> Quality & Documentation
Key specification parameters include assay (≥97.0% on dried basis), related substances (N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine, other impurities), loss on drying (≤0.5%), residue on ignition, heavy metals (Pb ≤1 ppm), specific rotation, pH, and microbial limits. White to off-white crystalline powder. Identity confirmed by HPLC, specific rotation, and IR. COA and MSDS are standard.
> Packaging
Neotame is a white crystalline powder. Non-hygroscopic under normal conditions. Standard packaging includes 5 kg or 25 kg aluminum foil bags in fibre drums, vacuum-sealed. Store at controlled room temperature (15–25 °C) in dry conditions. Shelf life is typically 36 months. Labels and documents are checked before dispatch.
> Pricing & MOQ
Pricing is quoted by specification, packaging and destination. Common commercial discussions use 25 kg bag/drum formats, pallet quantities and production-campaign planning; smaller samples may be reviewed for qualified formulation teams.
> Regulatory & Compounding Context
Neotame is approved as a food additive in the EU (E961, Regulation 1333/2008, maximum use levels by food category), US (FDA-approved, 21 CFR 172.829), Australia/NZ, and over 50 countries. ADI: 2 mg/kg bw/day (JECFA/EFSA). Unlike aspartame, neotame does not require phenylalanine (PKU) labeling because it is metabolized differently and yields negligible phenylalanine. No special import permits.
> Alias Index
- Chemical name: N-[N-(3,3-Dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester
- CAS Number: 165450-17-9
- Formula: C₂₀H₃₀N₂O₅ (MW 378.46)
- EU food additive: E961
- Sweetness: 7,000–13,000× sucrose
- Structural parent: Aspartame (N-3,3-dimethylbutyl derivative)
- InChIKey: HLIAVLHNDJUHFG-HOTGVXAUSA-N
- Commercial request terms: neotame food grade, E961, ultra-high-potency sweetener, feed flavoring sweetener, TCS Industries Limited
> FAQ
How does Neotame differ from Aspartame?
Neotame is 35–65 times sweeter than aspartame (7,000–13,000× vs. 200× sucrose). The 3,3-dimethylbutyl group blocks peptidase cleavage, so neotame does not yield significant phenylalanine and requires no PKU labeling. Neotame is also heat-stable, unlike aspartame. Both are dipeptide-based sweeteners.
What documents are available for Neotame orders?
COA and MSDS are standard for commercial discussions. COO, packing list, invoice and other import-support documents can be arranged according to order scope.
Do you supply Neotame to Germany, France and Spain?
Yes. We support B2B buyers in Germany, France, Italy, Spain, the United Kingdom, the Netherlands, Poland and Switzerland, subject to route and document review.
Do you supply the United States, Canada and Australia?
Yes. We review the United States, Canada, Australia and New Zealand for project supply, import documents, packaging and logistics planning before quotation.
Does Neotame require phenylalanine labeling?
No. Unlike aspartame, neotame is not hydrolyzed to free phenylalanine at relevant levels. Regulatory agencies (FDA, EFSA) do not require PKU warning labeling for neotame-containing products. This is a key regulatory advantage for products targeted at the PKU-sensitive population.
Is Neotame approved for animal feed?
Yes. Neotame is approved as a flavoring substance in animal feed in the EU (Regulation 1831/2003) and US (FDA GRAS). Its extreme potency means effective doses are in the range of 0.5–10 mg/kg feed, providing cost-effective palatability enhancement for livestock, poultry, and pet food.
Can you arrange samples before commercial purchasing?
Samples or evaluation quantities may be reviewed for qualified buyers after target specification, application and destination-market requirements are clarified.
How is Neotame packaged for export?
Packaging is confirmed by quantity and material properties. Typical options include foil bags, HDPE containers, fibre drums, 25 kg bags or palletized export packaging.
Can buyer-defined specifications be reviewed?
Yes. Send the specification, methods, impurity limits and required documents. TCS can review feasibility before confirming quotation and lead time.
What payment terms are normally used?
Standard payment is 100% T/T before dispatch unless a different arrangement has been approved for an established commercial account.
What lead time should buyers expect?
Lead time depends on stock, batch size, document scope and destination. Available stock can move faster; made-to-order or pallet programs require longer planning.
What is the cost advantage of Neotame?
Neotame provides sweetness equivalent to 1 kg of sucrose at approximately 0.08–0.14 g, making it a highly cost-effective sweetener on a sweetness-equivalent basis. This offsets the higher per-kilogram price. Formulators should calculate cost on a sucrose-equivalent basis for comparison.
Last reviewed: June 2026
Evaluation and research orders (≤10 kg) are shipped with COA, MSDS, and certificate of origin. Bulk commercial orders (>10 kg) qualify for volume pricing with a full technical documentation package available on request.
> Request a Quote
If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.