Lomustine (CCNU): Nitrosourea Alkylating Agent
Lomustine is a lipophilic nitrosourea alkylating agent that crosslinks DNA strands, disrupting DNA replication and transcription. Its high lipophilicity allows it to cross the blood-brain barrier, making it particularly useful in the treatment of central nervous system tumors. Lomustine also has activity against a range of hematologic malignancies.
Product Profile
| CAS Number | 13010-47-4 |
|---|---|
| Molecular Formula | C9H16ClN3O2 |
| Appearance | Yellow powder |
| Therapeutic Category | Antineoplastic / Alkylating Agent |
| Storage | Store at 2–8°C |
Applications
Lomustine is administered orally, typically as a single dose every 6 weeks, for the treatment of brain tumors (both primary and metastatic) and Hodgkin’s lymphoma in patients who have relapsed or failed to respond to initial therapy. It is one of the few chemotherapy agents with reliable CNS penetration. In veterinary oncology, lomustine is used in dogs for the treatment of mast cell tumors, lymphoma, and histiocytic sarcoma. The delayed and cumulative myelosuppression characteristic of nitrosoureas requires careful hematologic monitoring.
Why Source from TCS
TCS supplies lomustine to pharmaceutical companies across Europe and globally. Flexible order quantities from development samples to commercial volumes. Contact us with your target market and project requirements for a tailored quotation.
FAQ
What information should be included in an inquiry for Lomustine 13010-47-4?
A useful inquiry normally includes the product name, target application, estimated quantity, destination market, and any specific documentation or packaging requests.
How is Lomustine 13010-47-4 usually evaluated for sourcing?
This product is positioned for pharmaceutical sourcing discussions covering development, pilot, or commercial demand, subject to the buyer confirming application scope, market, and document requirements.
What documentation and commercial points are commonly reviewed before buying Lomustine 13010-47-4?
For pharmaceutical API procurement, buyers commonly align on specification review, target market, batch or annual demand, packaging expectations, and the documentation package needed for the project.
Request a Quote
If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.