TCS Industries Limited (China-sourced API supplier) supplies Methylcobalamin — API CAS 13422-55-4 for pharmaceutical B2B procurement — COA, MSDS, and technical documentation available on request.
> Overview
| Product Name | Methylcobalamin |
|---|---|
| Structural Formula |  |
| CAS Number | 13422-55-4 |
| Molecular Formula | C63H91CoN13O14P |
| Molecular Weight | 1344.4 g/mol |
| InChIKey | ZFLASALABLFSNM-WYVZQNDMSA-L |
| SMILES | Available on request where applicable |
| Appearance | Dark red crystalline powder |
| Purity / Grade | By agreed specification and batch COA |
| Storage | 2–8°C, protect from light, store under inert gas |
Methylcobalamin (CAS 13422-55-4) is a biologically active coenzyme form of vitamin B12 with the formula C₆₃H₉₁CoN₁₃O₁₄P (MW 1344.38). Unlike cyanocobalamin, methylcobalamin carries a methyl group directly coordinated to cobalt and functions as a cofactor for methionine synthase in homocysteine metabolism. It is used in pharmaceutical products for treatment of peripheral neuropathy, vitamin B12 deficiency, and as a nutritional supplement.
TCS Industries Limited, a Hong Kong-based trading and sourcing company, supplies Methylcobalamin in pharmaceutical and nutraceutical grades for global procurement programs.
> Applications
Peripheral neuropathy treatment
Methylcobalamin is used in oral and injectable formulations for treatment of diabetic neuropathy, post-herpetic neuralgia, and other peripheral nerve disorders. Clinical dosing ranges from 500 mcg to 1500 mcg orally, or 500 mcg intramuscularly. It promotes nerve regeneration and is widely prescribed in Japan, China and other Asian markets. Yaqub et al. (J Coll Physicians Surg Pak, 2000, 10:137–140) evaluated methylcobalamin efficacy in diabetic neuropathy, demonstrating improvement in nerve conduction velocity and symptom scores.
Nutritional supplement and food fortification
Methylcobalamin is a preferred B12 form in dietary supplements marketed to consumers who want the active coenzyme rather than the synthetic cyanocobalamin form. It is used in sublingual tablets, capsules, and functional food applications. Stability considerations are important: methylcobalamin is light-sensitive and requires protection from UV exposure during manufacturing, storage and packaging.
> Sourcing & Supply
TCS Industries Limited supports development, qualification and commercial purchasing discussions for Methylcobalamin with buyers in Australia, New Zealand, Canada and South Korea.
- Evaluation and commercial quantities: sample vials (light-protected) for qualification; 1 kg to 25 kg packaging for production. Pharma and nutraceutical grades available.
- Pallet quantities and production campaigns: repeat supply is coordinated against packaging, lead time, annual demand and destination-market import requirements.
> Quality & Documentation
Key specification parameters include assay (≥96.0% on dried basis for pharma grade, ≥98.0% for premium nutraceutical), loss on drying, related substances (cyanocobalamin, hydroxocobalamin), residual solvents, heavy metals, and microbial limits. The characteristic red colour and UV-Vis absorption spectrum (λmax ~266 nm, ~341 nm, ~525 nm) are identity markers. Light sensitivity requires HPLC analysis under amber-light conditions. COA and MSDS are standard.
> Packaging
Methylcobalamin is light-sensitive and must be protected from UV radiation throughout the supply chain. Standard packaging includes amber glass bottles, aluminum foil bags, or double-layered PE/Al/PE bags in fibre drums. All packaging is light-proof. Store at 2–8 °C or controlled room temperature (15–25 °C) depending on grade. Labels and documents are checked before dispatch.
> Pricing & MOQ
Pricing is quoted by specification, packaging and destination. Common commercial discussions use 25 kg bag/drum formats, pallet quantities and production-campaign planning; smaller samples may be reviewed for qualified formulation teams.
> Regulatory & Compounding Context
Methylcobalamin is monographed in JP (Japanese Pharmacopoeia) and is listed in the FDA IID. It is an authorized form of vitamin B12 in food supplements under EU Directive 2002/46/EC. Widely registered as a pharmaceutical product in Asian markets (Japan, China, India). Not currently monographed in USP or Ph.Eur. (which monograph cyanocobalamin and hydroxocobalamin). Buyers should specify target market regulatory requirements at inquiry.
> Alias Index
- IUPAC: Methylcobalamin
- CAS Number: 13422-55-4
- Formula: C₆₃H₉₁CoN₁₃O₁₄P (MW 1344.38)
- Other B12 forms: Cyanocobalamin (CAS 68-19-9), Hydroxocobalamin (CAS 13422-51-0), Adenosylcobalamin (CAS 13870-90-1)
- Common names: MeCbl, Mecobalamin, MeB12, Methyl-B12
- InChIKey: GZJLLYHBALOKEX-UHFFFAOYSA-N
- Commercial request terms: methylcobalamin API, mecobalamin pharma grade, vitamin B12 active form, MeCbl bulk, TCS Industries Limited
> FAQ
What is the difference between Methylcobalamin and Cyanocobalamin?
Methylcobalamin (CAS 13422-55-4) is a naturally occurring active coenzyme form of B12 with a methyl group on cobalt. Cyanocobalamin (CAS 68-19-9) is a synthetic form with a cyanide group that must be converted to active forms in the body. Methylcobalamin is light-sensitive; cyanocobalamin is more stable.
What documents are available for Methylcobalamin orders?
COA and MSDS are standard for commercial discussions. COO, packing list, invoice and other import-support documents can be arranged according to order scope.
Do you supply Methylcobalamin to Australia and Canada?
Yes. We support B2B buyers in Australia, New Zealand, Canada and South Korea, subject to route and document review.
Do you supply New Zealand and South Korea?
Yes. We review Australia, New Zealand, Canada and South Korea for project supply, import documents, packaging and logistics planning before quotation.
Is Methylcobalamin light-sensitive?
Yes. Methylcobalamin degrades upon exposure to UV and visible light. Manufacturing, analysis and packaging must be performed under amber or sodium-vapor lighting. Storage in light-proof containers is mandatory. This is a key handling difference versus cyanocobalamin.
What pharmaceutical grades does TCS supply?
TCS sources pharmaceutical grade (JP-compliant) and nutraceutical grade methylcobalamin. Assay ranges from ≥96.0% to ≥98.0% on dried basis depending on grade. Specify the target market pharmacopoeia and intended formulation at inquiry.
Can you arrange samples before commercial purchasing?
Samples or evaluation quantities may be reviewed for qualified buyers after target specification, application and destination-market requirements are clarified.
How is Methylcobalamin packaged for export?
Packaging is confirmed by quantity and material properties. Typical options include foil bags, HDPE containers, fibre drums, 25 kg bags or palletized export packaging.
Can buyer-defined specifications be reviewed?
Yes. Send the specification, methods, impurity limits and required documents. TCS can review feasibility before confirming quotation and lead time.
What payment terms are normally used?
Standard payment is 100% T/T before dispatch unless a different arrangement has been approved for an established commercial account.
What lead time should buyers expect?
Lead time depends on stock, batch size, document scope and destination. Available stock can move faster; made-to-order or pallet programs require longer planning.
Is Methylcobalamin approved for food supplements in the EU?
Yes. Methylcobalamin is listed as an authorized form of vitamin B12 in food supplements under EU Directive 2002/46/EC. It can be used in tablets, capsules and functional foods. Material must meet EU food supplement purity criteria.
Last reviewed: June 2026
Evaluation and research orders (≤10 kg) are shipped with COA, MSDS, and certificate of origin. Bulk commercial orders (>10 kg) qualify for volume pricing with a full technical documentation package available on request.
> Request a Quote
If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.