TCS Industries Limited (China-sourced API supplier) supplies Hydrocortisone — API CAS 74050-20-7 for pharmaceutical B2B procurement — COA, MSDS, and technical documentation available on request.
> Overview
| Product Name | Hydrocortisone |
|---|---|
| Structural Formula |  |
| CAS Number | 74050-20-7 |
| Molecular Formula | C₂₆H₃₆O₇ |
| Molecular Weight | 460.6 g/mol |
| InChIKey | MFBMYAOAMQLLPK-FZNHGJLXSA-N |
| SMILES | Available on request where applicable |
| Appearance | White to slightly yellowish crystalline powder |
| Purity / Grade | By agreed specification and batch COA |
| Storage | Store at controlled room temperature, protect from light |
Hydrocortisone Aceponate (CAS 74050-20-7) is a diester prodrug of hydrocortisone with the formula C₂₆H₃₈O₇ (MW 466.57). It is a medium-potency topical corticosteroid designed for dermal use, combining anti-inflammatory efficacy with reduced systemic absorption. Hydrocortisone aceponate is activated by skin esterases to hydrocortisone-17-propionate, the pharmacologically active metabolite.
TCS Industries Limited, a Hong Kong-based trading and sourcing company, supplies Hydrocortisone Aceponate API for global pharmaceutical procurement programs.
> Applications
Topical anti-inflammatory for dermatitis
Hydrocortisone aceponate 0.127% cream or ointment is used for eczema, contact dermatitis, and other corticosteroid-responsive dermatoses. Its double-ester prodrug design enables high skin penetration with rapid inactivation in the systemic circulation, reducing HPA axis suppression risk. Niedner et al. (J Dermatolog Treat, 1998, 9:223–227) evaluated the therapeutic index of hydrocortisone aceponate compared to other topical corticosteroids in atopic dermatitis.
Veterinary dermatology
Hydrocortisone aceponate spray (0.0584%) is used in veterinary medicine for canine atopic dermatitis (Cortavance, Virbac). The topical spray formulation provides localized anti-inflammatory action on inflamed skin areas without significant systemic corticosteroid effects.
> Sourcing & Supply
TCS Industries Limited supports development, qualification and commercial purchasing discussions for Hydrocortisone with buyers in Australia, New Zealand, Canada and South Korea.
- Evaluation and commercial quantities: 100 g samples for analytical qualification; 1 kg for formulation development; 5–25 kg for production. Pharmaceutical API grade in crystalline powder form available.
- Pallet quantities and production campaigns: repeat supply is coordinated against packaging, lead time, annual demand and destination-market import requirements.
> Quality & Documentation
Key specification parameters include assay (≥97.0%), related substances (individual ≤0.5%, total ≤1.5%), specific optical rotation, loss on drying, residual solvents, heavy metals, and microbial limits. White to slightly yellowish crystalline powder. Slightly soluble in water, soluble in ethanol and acetone. Identity by HPLC and IR. Meets in-house pharmaceutical specifications. COA, MSDS, and stability data are standard.
> Packaging
Hydrocortisone aceponate is a white to slightly yellowish crystalline powder. Protect from light and moisture. Standard packaging includes double PE-lined aluminium foil bags in fibre drums (1 kg or 5 kg). Store at controlled room temperature (15–25 °C). Shelf life is typically 36 months. Labels and documents are checked before dispatch.
> Pricing & MOQ
Pricing is quoted by specification, packaging and destination. Common commercial discussions use 25 kg bag/drum formats, pallet quantities and production-campaign planning; smaller samples may be reviewed for qualified formulation teams.
> Regulatory & Compounding Context
Hydrocortisone aceponate is registered as a topical corticosteroid in multiple European and Asian markets (Efficort cream/ointment). Not FDA-approved in the US. Veterinary authorization in the EU (Cortavance spray, Virbac). Generic registration requires full dossier with in-vivo dermatopharmacokinetic or clinical equivalence data. DMF support available.
> Alias Index
- INN: Hydrocortisone aceponate
- CAS Number: 74050-20-7
- Formula: C₂₆H₃₈O₇ (MW 466.57)
- Brand names: Efficort (human), Cortavance (veterinary, Virbac)
- Active metabolite: Hydrocortisone 17-propionate
- Pharmacological class: Topical corticosteroid (medium potency)
- Commercial request terms: hydrocortisone aceponate API, Efficort generic, topical corticosteroid bulk, HCA powder, TCS Industries Limited
> FAQ
What is the prodrug activation mechanism?
Hydrocortisone aceponate has ester groups at C-17 (propionate) and C-21 (acetate). Skin esterases cleave the C-21 acetate first, producing hydrocortisone 17-propionate (the active metabolite). Systemic esterases then rapidly cleave the C-17 propionate to inactive hydrocortisone, which is further metabolized. This sequential activation-inactivation gives high local potency with low systemic exposure.
What documents are available for Hydrocortisone orders?
COA and MSDS are standard for commercial discussions. COO, packing list, invoice and other import-support documents can be arranged according to order scope.
Do you supply Hydrocortisone to Australia and Canada?
Yes. We support B2B buyers in Australia, New Zealand, Canada and South Korea, subject to route and document review.
Do you supply New Zealand and South Korea?
Yes. We review Australia, New Zealand, Canada and South Korea for project supply, import documents, packaging and logistics planning before quotation.
How does it compare to Hydrocortisone Butyrate?
Both are medium-potency topical corticosteroids. Hydrocortisone aceponate has a faster systemic inactivation rate due to its double-ester design, potentially offering a better therapeutic index. Hydrocortisone butyrate (CAS 13609-67-1) is FDA-approved in the US. Selection depends on regulatory market and formulation requirements.
Is this product used in veterinary medicine?
Yes. Hydrocortisone aceponate 0.0584% spray (Cortavance, Virbac) is authorized in the EU for canine atopic dermatitis. It provides topical anti-inflammatory action without significant systemic absorption. The veterinary formulation uses a different concentration and vehicle than the human product.
Can you arrange samples before commercial purchasing?
Samples or evaluation quantities may be reviewed for qualified buyers after target specification, application and destination-market requirements are clarified.
How is Hydrocortisone packaged for export?
Packaging is confirmed by quantity and material properties. Typical options include foil bags, HDPE containers, fibre drums, 25 kg bags or palletized export packaging.
Can buyer-defined specifications be reviewed?
Yes. Send the specification, methods, impurity limits and required documents. TCS can review feasibility before confirming quotation and lead time.
What payment terms are normally used?
Standard payment is 100% T/T before dispatch unless a different arrangement has been approved for an established commercial account.
What lead time should buyers expect?
Lead time depends on stock, batch size, document scope and destination. Available stock can move faster; made-to-order or pallet programs require longer planning.
What formulation types are used?
Human formulations include 0.127% cream, ointment, and lipophilic cream. The API is slightly soluble in water and requires lipophilic vehicle systems. Emulsion-based (o/w and w/o) formulations are standard. Formulation pH should be 4.0–7.0. Stability studies should include assessment of ester hydrolysis under accelerated conditions.
Last reviewed: June 2026
Evaluation and research orders (≤10 kg) are shipped with COA, MSDS, and certificate of origin. Bulk commercial orders (>10 kg) qualify for volume pricing with a full technical documentation package available on request.
> Request a Quote
If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.