Pimobendan: Inodilator for Veterinary Cardiology
Pimobendan is a benzimidazole-pyridazinone derivative that acts as both a positive inotrope and a vasodilator (inodilator). It increases cardiac contractility by sensitizing cardiac troponin C to calcium, and reduces afterload through inhibition of phosphodiesterase III (PDE III) in vascular smooth muscle. This dual mechanism improves cardiac output without substantially increasing myocardial oxygen demand.
Product Profile
| CAS Number | 74150-27-9 |
|---|---|
| Molecular Formula | C19H18N4O2 |
| Appearance | White to yellowish crystalline powder |
| Therapeutic Category | Veterinary Cardiovascular Agent / Inodilator |
| Storage | Store at controlled room temperature, protect from moisture |
Applications
Pimobendan is the standard of care for the management of congestive heart failure in dogs secondary to dilated cardiomyopathy (DCM) or myxomatous mitral valve disease (MMVD). It is also approved for preclinical use in dogs with MMVD and cardiomegaly (EPIC trial evidence), where it delays the onset of heart failure. The compound is formulated as chewable oral tablets for dogs, typically dosed at 0.2–0.3 mg/kg twice daily. It is used in combination with diuretics and ACE inhibitors as part of a complete heart failure management protocol.
Why Source from TCS
TCS supplies pimobendan to veterinary pharmaceutical companies across Europe and globally. Flexible order quantities from development samples to commercial volumes. Contact us with your target market and project requirements for a tailored quotation.
FAQ
What information should be included in an inquiry for Pimobendan 74150-27-9?
A useful inquiry normally includes the product name, target application, estimated quantity, destination market, and any specific documentation or packaging requests.
How is Pimobendan 74150-27-9 usually evaluated for sourcing?
This product is positioned for pharmaceutical sourcing discussions covering development, pilot, or commercial demand, subject to the buyer confirming application scope, market, and document requirements.
What documentation and commercial points are commonly reviewed before buying Pimobendan 74150-27-9?
For pharmaceutical API procurement, buyers commonly align on specification review, target market, batch or annual demand, packaging expectations, and the documentation package needed for the project.
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