TCS Industries Limited (China-sourced API supplier) supplies Pimobendan — API CAS 74150-27-9 for pharmaceutical B2B procurement — COA, MSDS, and technical documentation available on request.
> Overview
| Product Name | Pimobendan |
|---|---|
| Structural Formula |  |
| CAS Number | 74150-27-9 |
| Molecular Formula | C19H18N4O2 |
| Molecular Weight | 334.4 g/mol |
| InChIKey | GLBJJMFZWDBELO-UHFFFAOYSA-N |
| SMILES | Available on request where applicable |
| Appearance | Yellowish to yellowish-green crystalline powder |
| Purity / Grade | By agreed specification and batch COA |
| Storage | Store at controlled room temperature, protect from moisture |
Pimobendan (CAS 74150-27-9) is a calcium-sensitizer and phosphodiesterase III (PDE3) inhibitor with the formula C₁₉H₁₈N₄O₂ (MW 334.37). It has a dual mechanism: calcium sensitization of cardiac troponin C enhances myocardial contractility, while PDE3 inhibition causes vasodilation. Pimobendan is the standard treatment for canine congestive heart failure secondary to myxomatous mitral valve disease (MMVD) and dilated cardiomyopathy (DCM).
TCS Industries Limited, a Hong Kong-based trading and sourcing company, supplies Pimobendan API in development and commercial quantities for veterinary oral dosage form programs.
> Applications
Canine congestive heart failure
Pimobendan is the active ingredient in chewable tablets administered to dogs with CHF from MMVD or DCM. The EPIC trial (Boswood et al., J Vet Intern Med, 2016, 30:1765–1779) demonstrated that pre-clinical pimobendan delayed onset of CHF in dogs with MMVD by a median of 15 months. Standard dosing is 0.2–0.3 mg/kg twice daily, which drives tablet strength requirements of 1.25 mg, 2.5 mg, 5 mg and 10 mg for weight-based dosing.
Veterinary compounding and combination formulations
Compounding pharmacies prepare pimobendan oral suspensions and flavored chewable formulations for dogs that cannot take commercial tablets. Pimobendan has low aqueous solubility (approximately 10 mg/L at pH 7) and is formulated with cyclodextrin complexation or pH-adjusted vehicles. Some veterinary cardiologists prescribe pimobendan in combination with furosemide, spironolactone and an ACE inhibitor for multi-drug CHF management.
> Sourcing & Supply
TCS Industries Limited supports development, qualification and commercial purchasing discussions for Pimobendan with buyers in Australia, New Zealand, Canada and South Korea.
- Development and qualification quantities: 100 g to 5 kg packs for formulation trials, analytical method validation, and veterinary drug registration submissions.
- Pallet quantities and production campaigns: repeat supply is coordinated against packaging, lead time, annual demand and destination-market import requirements.
> Quality & Documentation
Key specification parameters include assay (≥99.0%), related substances, loss on drying, residue on ignition, heavy metals, residual solvents, and microbial limits. Yellowish-green crystalline powder. Practically insoluble in water, soluble in DMSO. Identity by HPLC and IR. Meets in-house veterinary pharmaceutical specifications. COA and MSDS are standard.
> Packaging
Pimobendan is a yellowish-green crystalline powder. Standard packaging includes double PE-lined foil bags in fibre drums (100 g, 500 g, 1 kg, or 5 kg). Store at controlled room temperature (15–25 °C). Protect from light. Shelf life is typically 36 months. Labels and documents are checked before dispatch.
> Pricing & MOQ
Pricing is quoted by specification, packaging and destination. Common commercial discussions use 25 kg bag/drum formats, pallet quantities and production-campaign planning; smaller samples may be reviewed for qualified formulation teams.
> Regulatory & Compounding Context
Pimobendan is approved for veterinary use only. FDA-CVM approved in 2007 (Vetmedin, Boehringer Ingelheim) for management of CHF in dogs from MMVD or DCM. EMA-authorized for veterinary use. Not approved for human use. Generic pimobendan products available in some markets. Regulatory documentation available for veterinary ANDA/generic applications.
> Alias Index
- INN: Pimobendan
- CAS Number: 74150-27-9
- Formula: C₁₉H₁₈N₄O₂ (MW 334.37)
- Brand name: Vetmedin (Boehringer Ingelheim)
- ATCvet code: QC01CE90
- Pharmacological class: Calcium sensitizer / PDE3 inhibitor (inodilator)
- Commercial request terms: pimobendan API, Vetmedin generic, veterinary cardiac API, canine heart failure, TCS Industries Limited
> FAQ
What tablet strengths can be formulated from Pimobendan API?
Commercial pimobendan tablets are available in 1.25 mg, 2.5 mg, 5 mg and 10 mg strengths for weight-based dosing in dogs at 0.2–0.3 mg/kg BID. API particle size and polymorphic form should be specified at inquiry to match the target formulation and dissolution profile.
What documents are available for Pimobendan orders?
COA and MSDS are standard for commercial discussions. COO, packing list, invoice and other import-support documents can be arranged according to order scope.
Do you supply Pimobendan to Australia and Canada?
Yes. We support B2B buyers in Australia, New Zealand, Canada and South Korea, subject to route and document review.
Do you supply New Zealand and South Korea?
Yes. We review Australia, New Zealand, Canada and South Korea for project supply, import documents, packaging and logistics planning before quotation.
Is Pimobendan used in cats or other species?
Pimobendan is approved for dogs. Off-label use in cats with hypertrophic cardiomyopathy (HCM) and CHF has been reported in veterinary cardiology literature, but it is not formally approved for feline use. Buyers formulating for non-canine species should confirm local regulatory requirements.
What is the shelf life and storage condition for Pimobendan API?
Pimobendan API is typically stored at controlled room temperature (15–25 °C), protected from moisture and light. Shelf life is batch-specific and stated on the COA. Buyers should request stability data if planning long-term inventory or warm-climate storage.
Can you arrange samples before commercial purchasing?
Samples or evaluation quantities may be reviewed for qualified buyers after target specification, application and destination-market requirements are clarified.
How is Pimobendan packaged for export?
Packaging is confirmed by quantity and material properties. Typical options include foil bags, HDPE containers, fibre drums, 25 kg bags or palletized export packaging.
Can buyer-defined specifications be reviewed?
Yes. Send the specification, methods, impurity limits and required documents. TCS can review feasibility before confirming quotation and lead time.
What payment terms are normally used?
Standard payment is 100% T/T before dispatch unless a different arrangement has been approved for an established commercial account.
What lead time should buyers expect?
Lead time depends on stock, batch size, document scope and destination. Available stock can move faster; made-to-order or pallet programs require longer planning.
What is the difference between Pimobendan and Vetmedin?
Pimobendan is the active pharmaceutical ingredient (INN). Vetmedin is the branded finished product manufactured by Boehringer Ingelheim. TCS supplies the API (CAS 74150-27-9), not the finished tablet. Buyers developing generic veterinary pimobendan products source the API separately for their own formulation and registration.
Last reviewed: June 2026
Evaluation and research orders (≤10 kg) are shipped with COA, MSDS, and certificate of origin. Bulk commercial orders (>10 kg) qualify for volume pricing with a full technical documentation package available on request.
> Request a Quote
If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.