TCS Industries Limited (China-sourced API supplier) supplies Tobramycin Sulfate — API CAS 79645-27-5 for pharmaceutical B2B procurement — COA, MSDS, and technical documentation available on request.
> Overview
| Product Name | Tobramycin Sulfate |
|---|---|
| Structural Formula |  |
| CAS Number | 79645-27-5 |
| Molecular Formula | C18H39N5O13S |
| Molecular Weight | 565.6 g/mol |
| InChIKey | ZEUUPKVZFKBXPW-UHFFFAOYSA-N |
| SMILES | Available on request where applicable |
| Appearance | White to off-white hygroscopic powder |
| Purity / Grade | By agreed specification and batch COA |
| Storage | Store at controlled room temperature |
Tobramycin Sulfate (CAS 79645-27-5) is an aminoglycoside antibiotic sulfate salt with the formula C₁₈H₃₇N₅O₉·xH₂SO₄ (free base MW 467.51). Produced by Streptomyces tenebrarius, tobramycin inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. It is used for serious Gram-negative infections including Pseudomonas aeruginosa, and as inhaled therapy for cystic fibrosis lung infections.
TCS Industries Limited, a Hong Kong-based trading and sourcing company, supplies Tobramycin Sulfate API in pharmaceutical grade for global procurement programs.
> Applications
Parenteral aminoglycoside therapy
Tobramycin IV/IM 3–5 mg/kg/day is used for serious Gram-negative infections (Pseudomonas, Klebsiella, Enterobacter, Serratia, E. coli). It has particular clinical importance for Pseudomonas aeruginosa, against which it has the highest activity among aminoglycosides. Craig et al. (Clin Infect Dis, 1997, 25:215–224) described the pharmacodynamic principles of aminoglycoside dosing, including once-daily dosing (extended-interval) to optimize the concentration-dependent killing and post-antibiotic effect.
Inhaled and ophthalmic formulations
Tobramycin inhalation solution (300 mg/5 mL, TOBI) and dry powder inhaler (Bethkis, TOBI Podhaler) are used for chronic Pseudomonas aeruginosa lung infection in cystic fibrosis. Tobramycin 0.3% ophthalmic solution/ointment (Tobrex) is used for bacterial conjunctivitis and keratitis.
> Sourcing & Supply
TCS Industries Limited supports development, qualification and commercial purchasing discussions for Tobramycin Sulfate with buyers in Australia, New Zealand, Canada and South Korea.
- Evaluation and commercial quantities: 100 g samples for analytical qualification; 1 kg and 5 kg for production. Fermentation-derived pharmaceutical-grade powder. Parenteral and non-parenteral grades available. DMF reference letters provided.
- Pallet quantities and production campaigns: repeat supply is coordinated against packaging, lead time, annual demand and destination-market import requirements.
> Quality & Documentation
Key specification parameters include assay (≥90.0% tobramycin base equivalents), related substances (kanamycin B/nebramycin factor 6, nebramine), sulfate content, pH (3.0–6.5 in solution), loss on drying, heavy metals, residual solvents, endotoxin (for parenteral grade), and microbial limits. White to off-white powder. Freely soluble in water. Identity by HPLC and IR. Meets USP (Tobramycin Sulfate), Ph.Eur. (Tobramycinum), and BP. COA and MSDS are standard.
> Packaging
Tobramycin sulfate is a white to off-white hygroscopic powder. Standard packaging includes double PE-lined foil bags in fibre drums (100 g, 500 g, 1 kg, or 5 kg). Store at controlled room temperature (15–25 °C). Protect from moisture. Shelf life is typically 36 months. Labels and documents are checked before dispatch.
> Pricing & MOQ
Pricing is quoted by specification, packaging and destination. Common commercial discussions use 25 kg bag/drum formats, pallet quantities and production-campaign planning; smaller samples may be reviewed for qualified formulation teams.
> Regulatory & Compounding Context
Tobramycin is monographed in USP (Tobramycin, Tobramycin Sulfate), Ph.Eur. (Tobramycinum), and BP. FDA-approved for injection (1975), inhalation (1997, TOBI), and ophthalmic (Tobrex). On the WHO Model List of Essential Medicines (injection). Multiple generic approvals. DMF support available from qualified manufacturers.
> Alias Index
- INN: Tobramycin
- CAS Number: 79645-27-5 (sulfate); 32986-56-4 (free base)
- Formula: C₁₈H₃₇N₅O₉ (free base MW 467.51)
- Brand names: Nebcin (injection), TOBI (inhalation), Tobrex (ophthalmic)
- ATC code: J01GB01 (systemic), S01AA12 (ophthalmic)
- Related: Gentamicin, Amikacin (other aminoglycosides)
- Commercial request terms: tobramycin sulfate API, Nebcin generic, aminoglycoside API, Pseudomonas antibiotic, TCS Industries Limited
> FAQ
Why is Tobramycin preferred for Pseudomonas?
Tobramycin has the highest in-vitro activity against Pseudomonas aeruginosa among aminoglycosides (MIC90 ~1–2 mg/L). It is less susceptible to Pseudomonas aminoglycoside-modifying enzymes compared to gentamicin. This Pseudomonas selectivity is the primary reason tobramycin is the aminoglycoside of choice in cystic fibrosis lung infection management.
What documents are available for Tobramycin Sulfate orders?
COA and MSDS are standard for commercial discussions. COO, packing list, invoice and other import-support documents can be arranged according to order scope.
Do you supply Tobramycin Sulfate to Australia and Canada?
Yes. We support B2B buyers in Australia, New Zealand, Canada and South Korea, subject to route and document review.
Do you supply New Zealand and South Korea?
Yes. We review Australia, New Zealand, Canada and South Korea for project supply, import documents, packaging and logistics planning before quotation.
What is therapeutic drug monitoring for Tobramycin?
Once-daily dosing: peak 20–30 mg/L, trough <1 mg/L. Traditional dosing (8-hourly): peak 6–10 mg/L, trough <2 mg/L. Trough monitoring prevents nephrotoxicity and ototoxicity. Dose adjustment is required in renal impairment (extend interval based on creatinine clearance). TDM is mandatory for aminoglycoside therapy.
How does inhaled Tobramycin work in cystic fibrosis?
Inhaled tobramycin delivers high drug concentrations (>25× MIC) directly to infected airway surfaces while minimizing systemic exposure. Standard regimen is 300 mg nebulized twice daily, 28 days on / 28 days off, alternating. This cycling schedule manages bacterial resistance and preserves efficacy over long-term use.
Can you arrange samples before commercial purchasing?
Samples or evaluation quantities may be reviewed for qualified buyers after target specification, application and destination-market requirements are clarified.
How is Tobramycin Sulfate packaged for export?
Packaging is confirmed by quantity and material properties. Typical options include foil bags, HDPE containers, fibre drums, 25 kg bags or palletized export packaging.
Can buyer-defined specifications be reviewed?
Yes. Send the specification, methods, impurity limits and required documents. TCS can review feasibility before confirming quotation and lead time.
What payment terms are normally used?
Standard payment is 100% T/T before dispatch unless a different arrangement has been approved for an established commercial account.
What lead time should buyers expect?
Lead time depends on stock, batch size, document scope and destination. Available stock can move faster; made-to-order or pallet programs require longer planning.
Is a DMF available?
Yes. TCS sources tobramycin sulfate from fermentation-based manufacturers who maintain active DMFs with the FDA and ASMF/CEP with EMA. Parenteral-grade material with endotoxin testing is available. COA, stability data, and DMF reference letters provided.
Last reviewed: June 2026
Evaluation and research orders (≤10 kg) are shipped with COA, MSDS, and certificate of origin. Bulk commercial orders (>10 kg) qualify for volume pricing with a full technical documentation package available on request.
> Request a Quote
If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.