TCS Industries Limited (China-sourced API supplier) supplies Paclitaxel — API CAS 33069-62-4 for pharmaceutical B2B procurement — COA, MSDS, and technical documentation available on request.
> Overview
| Product Name | Paclitaxel |
|---|---|
| Structural Formula |  |
| CAS Number | 33069-62-4 |
| Molecular Formula | C47H51NO14 |
| Molecular Weight | 853.9 g/mol |
| InChIKey | RCINICONZNJXQF-MZXODVADSA-N |
| SMILES | Available on request where applicable |
| Appearance | White to off-white crystalline powder |
| Purity / Grade | By agreed specification and batch COA |
| Storage | 2–8°C, protect from light |
Paclitaxel (CAS 33069-62-4) is a taxane antineoplastic agent originally isolated from the bark of Taxus brevifolia (Pacific yew). It has the formula C₄₇H₅₁NO₁₄ (MW 853.91). Paclitaxel stabilizes microtubules against depolymerization, preventing normal mitotic spindle function and arresting cells in mitosis. It is used for breast, ovarian, lung, and other solid tumors, and is on the WHO Model List of Essential Medicines.
TCS Industries Limited, a Hong Kong-based trading and sourcing company, supplies Paclitaxel API in pharmaceutical grade for global procurement programs.
> Applications
Solid tumor chemotherapy
Paclitaxel IV 135–175 mg/m² every 3 weeks is used for breast cancer, ovarian cancer, NSCLC, and Kaposi sarcoma. Weekly low-dose paclitaxel (80 mg/m²) provides equivalent efficacy with better tolerability in some settings. It stabilizes microtubules by binding to beta-tubulin, preventing depolymerization required for mitotic spindle reorganization. Rowinsky et al. (J Natl Cancer Inst, 1990, 82:1247–1259) described the clinical pharmacology and antitumor activity of paclitaxel as the first taxane to enter clinical use and established the foundation for its use across multiple tumor types.
Formulation variants
Conventional paclitaxel (Taxol) uses Cremophor EL/ethanol solvent (hypersensitivity risk, requires premedication). Nab-paclitaxel (Abraxane) uses albumin-bound nanoparticle technology, eliminating Cremophor, reducing hypersensitivity, and allowing higher doses. Paclitaxel-coated drug-eluting stents and balloons are used in coronary and peripheral vascular interventions.
> Sourcing & Supply
TCS Industries Limited supports development, qualification and commercial purchasing discussions for Paclitaxel with buyers in Australia, New Zealand, Canada and South Korea.
- Evaluation and commercial quantities: 10 g samples for analytical qualification; 100 g and 1 kg for production. Semi-synthetic (from 10-deacetylbaccatin III, Taxus needles) pharmaceutical-grade powder. Cytotoxic API. DMF reference letters available.
- Pallet quantities and production campaigns: repeat supply is coordinated against packaging, lead time, annual demand and destination-market import requirements.
> Quality & Documentation
Key specification parameters include assay (≥97.0%), related substances (10-deacetylpaclitaxel, docetaxel, 7-epi-paclitaxel, baccatin III), water content, residual solvents, heavy metals, and microbial limits. White to off-white crystalline powder. Practically insoluble in water, soluble in methanol and ethanol. Handle as cytotoxic material. Identity by HPLC and IR. Meets USP (Paclitaxel) and Ph.Eur. (Paclitaxelum). COA and MSDS are standard.
> Packaging
Paclitaxel is a white to off-white crystalline powder, cytotoxic. Standard packaging includes sealed glass vials or double-sealed foil bags under nitrogen (10 g, 50 g, 100 g, or 500 g). Store at 2–8 °C. Protect from light. Cytotoxic substance labeling applies. Shelf life is typically 36 months at 2–8 °C. Labels and documents are checked before dispatch.
> Pricing & MOQ
Pricing is quoted by specification, packaging and destination. Common commercial discussions use 25 kg bag/drum formats, pallet quantities and production-campaign planning; smaller samples may be reviewed for qualified formulation teams.
> Regulatory & Compounding Context
Paclitaxel is monographed in USP and Ph.Eur. FDA-approved in 1992 (Taxol) for ovarian cancer, with subsequent approvals for breast cancer and NSCLC. Nab-paclitaxel (Abraxane) approved in 2005. EMA-authorized. On the WHO Model List of Essential Medicines. Multiple generic approvals. DMF support available.
> Alias Index
- INN: Paclitaxel
- CAS Number: 33069-62-4
- Formula: C₄₇H₅₁NO₁₄ (MW 853.91)
- Brand names: Taxol (conventional), Abraxane (nab-paclitaxel)
- ATC code: L01CD01
- Source: Semi-synthetic from 10-DAB (Taxus baccata needles)
- Related: Docetaxel (semi-synthetic taxane analog)
- Commercial request terms: paclitaxel API, Taxol generic, taxane API, nab-paclitaxel raw material, TCS Industries Limited
> FAQ
Why is premedication required for Taxol?
Conventional paclitaxel (Taxol) is dissolved in Cremophor EL (polyoxyethylated castor oil), which causes severe hypersensitivity reactions (anaphylaxis, bronchospasm) in ~30% of unpremedicated patients. Standard premedication includes dexamethasone, diphenhydramine, and ranitidine. Nab-paclitaxel (Abraxane) does not contain Cremophor and does not require premedication.
What documents are available for Paclitaxel orders?
COA and MSDS are standard for commercial discussions. COO, packing list, invoice and other import-support documents can be arranged according to order scope.
Do you supply Paclitaxel to Australia and Canada?
Yes. We support B2B buyers in Australia, New Zealand, Canada and South Korea, subject to route and document review.
Do you supply New Zealand and South Korea?
Yes. We review Australia, New Zealand, Canada and South Korea for project supply, import documents, packaging and logistics planning before quotation.
How is Paclitaxel produced commercially?
Modern commercial paclitaxel is produced semi-synthetically from 10-deacetylbaccatin III (10-DAB), extracted from renewable Taxus baccata (European yew) needles. 10-DAB is then chemically converted to paclitaxel in a multi-step synthesis. This is more sustainable than bark extraction (which kills the tree) and more practical than plant cell fermentation or total chemical synthesis.
What is nab-paclitaxel?
Nab-paclitaxel (Abraxane) is paclitaxel bound to human albumin nanoparticles (~130 nm). This eliminates the Cremophor solvent, allows 50% higher dosing (260 mg/m² vs. 175 mg/m²), removes premedication need, enables shorter infusion (30 min vs. 3 hrs), and enhances tumor uptake via albumin receptor-mediated transcytosis (SPARC pathway).
Can you arrange samples before commercial purchasing?
Samples or evaluation quantities may be reviewed for qualified buyers after target specification, application and destination-market requirements are clarified.
How is Paclitaxel packaged for export?
Packaging is confirmed by quantity and material properties. Typical options include foil bags, HDPE containers, fibre drums, 25 kg bags or palletized export packaging.
Can buyer-defined specifications be reviewed?
Yes. Send the specification, methods, impurity limits and required documents. TCS can review feasibility before confirming quotation and lead time.
What payment terms are normally used?
Standard payment is 100% T/T before dispatch unless a different arrangement has been approved for an established commercial account.
What lead time should buyers expect?
Lead time depends on stock, batch size, document scope and destination. Available stock can move faster; made-to-order or pallet programs require longer planning.
Is a DMF available?
Yes. TCS sources paclitaxel from semi-synthetic manufacturers who maintain active DMFs with the FDA and ASMF/CEP with EMA. Source material (10-DAB) is from sustainable Taxus needle harvesting. Cytotoxic API containment and cold chain logistics are standard. COA, stability data, and DMF reference letters provided.
Last reviewed: June 2026
Evaluation and research orders (≤10 kg) are shipped with COA, MSDS, and certificate of origin. Bulk commercial orders (>10 kg) qualify for volume pricing with a full technical documentation package available on request.
> Request a Quote
If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.