Doxorubicin Hydrochloride: Anthracycline Antineoplastic Antibiotic
Doxorubicin is an anthracycline antibiotic isolated from Streptomyces peucetius var. caesius. It intercalates into DNA, inhibits topoisomerase II, and generates free radicals, leading to DNA strand breaks and cell death. Doxorubicin is one of the most widely used and effective chemotherapy agents, active against a broad spectrum of solid tumors and hematologic malignancies.
Product Profile
| CAS Number | 25316-40-9 |
|---|---|
| Molecular Formula | C27H29NO11 · HCl |
| Appearance | Red-orange lyophilized powder |
| Therapeutic Category | Antineoplastic / Anthracycline |
| Storage | Store at 2–8°C, protect from light |
Applications
Doxorubicin HCl is administered intravenously for breast cancer, ovarian cancer, bladder cancer, thyroid cancer, soft tissue and bone sarcomas, Hodgkin’s and non-Hodgkin’s lymphoma, and acute lymphoblastic leukemia. It is a key component of numerous combination regimens including AC (doxorubicin/cyclophosphamide), CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone), and ABVD. Cumulative dose-dependent cardiotoxicity is the principal limitation, with lifetime cumulative doses generally kept below 450–550 mg/m². Liposomal formulations (pegylated and non-pegylated) improve the pharmacokinetic profile and reduce cardiotoxicity. In veterinary oncology, doxorubicin is used in dogs for lymphoma, hemangiosarcoma, and osteosarcoma.
Why Source from TCS
TCS supplies doxorubicin hydrochloride to pharmaceutical companies across Europe and globally. Flexible order quantities from development samples to commercial volumes. Contact us with your target market and project requirements for a tailored quotation.
FAQ
What information should be included in an inquiry for Doxorubicin HCl 25316-40-9?
A useful inquiry normally includes the product name, target application, estimated quantity, destination market, and any specific documentation or packaging requests.
How is Doxorubicin HCl 25316-40-9 usually evaluated for sourcing?
This product is positioned for pharmaceutical sourcing discussions covering development, pilot, or commercial demand, subject to the buyer confirming application scope, market, and document requirements.
What documentation and commercial points are commonly reviewed before buying Doxorubicin HCl 25316-40-9?
For pharmaceutical API procurement, buyers commonly align on specification review, target market, batch or annual demand, packaging expectations, and the documentation package needed for the project.
Request a Quote
If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.