Dimethyl sulfoxide (DMSO) is a highly versatile polar aprotic solvent widely used in pharmaceutical R&D, fine-chemical synthesis and advanced formulation work. Chemically, DMSO is an organosulfur compound that can dissolve both polar and nonpolar substances and is miscible with water and many organic solvents, which makes it a powerful medium for difficult reactions and solubilisation challenges.
On the TCS GROUP site,
Dimethyl Sulfoxide (DMSO) – Polar Aprotic Solvent & Penetration Enhancer
is positioned as a high-purity solvent suitable for pharmaceutical development, cell biology, analytical chemistry and industrial processing. In drug development, DMSO is frequently used as a stock solution solvent for poorly soluble APIs and as a reaction medium for complex organic synthesis.
Beyond its solvent power, DMSO is well known for its skin-penetration enhancing properties. In certain regions and under specific regulatory frameworks, it is employed in topical and transdermal formulations to improve permeation of active ingredients through the stratum corneum. This same behaviour explains why handling and safety are critical: DMSO can carry dissolved substances through the skin, so strict control over purity and contamination is essential.
Within the broader formulation toolbox of TCS INDUSTRIES LIMITED, DMSO fits naturally into the
category. It can be used together with solid excipients that manage flow, stability and dosage form performance, such as:
- Colloidal Silicon Dioxide – Glidant, Anti-Caking Agent & Adsorbent – to improve powder flow and reduce caking during solid-dosage manufacturing.
- Carboxymethylcellulose Sodium – Thickener, Stabilizer & Suspending Agent – for viscosity control and suspension stability in liquid or semi-solid dosage forms.
In topical systems, DMSO can be used at carefully controlled levels to aid penetration of APIs in creams, gels or solutions, often in combination with fatty alcohols and emulsifying waxes that shape texture and sensory feel. In injectable development and bioassays, it plays a key role as a cryoprotectant or solvent for high-potency compounds, but must always be managed with rigorous quality specifications and validated procedures.
With Dimethyl Sulfoxide (DMSO) from TCS INDUSTRIES LIMITED, manufacturers and research organisations gain access to a pharmaceutical-grade polar aprotic solvent and penetration enhancer supported by strong quality systems and a fully compatible excipient portfolio.