TCS Industries Limited (China-sourced API supplier) supplies Sodium Bicarbonate –- Effervescent Agent & Buffering Excipient CAS 144-55-8 for pharmaceutical B2B procurement — COA, MSDS, and technical documentation available on request.
> Overview
| Product Name | Sodium Bicarbonate –- Effervescent Agent & Buffering Excipient |
|---|---|
| Structural Formula |  |
| CAS Number | 144-55-8 |
| Molecular Formula | CHNaO3 |
| Molecular Weight | 84.01 g/mol |
| InChIKey | UIIMBOGNXHQVGW-UHFFFAOYSA-M |
| SMILES | Available on request where applicable |
| Appearance | White crystalline powder or granules |
| Purity / Grade | By agreed specification and batch COA |
| Storage | Keep tightly closed in a cool, dry, well-ventilated place |
Sodium Bicarbonate (CAS 144-55-8) is an inorganic salt with the formula NaHCO₃ (MW 84.01). It is a white, crystalline powder that generates carbon dioxide when reacting with acids, making it essential for effervescent formulations. Sodium bicarbonate is used as an antacid, effervescent agent, pH adjuster, and excipient in pharmaceutical, food, and industrial applications.
TCS Industries Limited, a Hong Kong-based trading and sourcing company, supplies Sodium Bicarbonate in pharmaceutical (USP/Ph.Eur.) and food grades for global procurement programs.
> Applications
Effervescent formulation component
Sodium bicarbonate reacts with citric acid or tartaric acid in the presence of water to generate CO₂, producing the effervescent effect in tablets, granules, and powders. Typical ratios are 1:1 to 1.5:1 (citric acid:sodium bicarbonate by weight). It is a critical component of effervescent drug delivery systems for rapid dissolution and palatability. Al-Khattawi et al. (Expert Opin Drug Deliv, 2014, 11:453–468) reviewed the formulation and technology of effervescent dosage forms.
Antacid and pH adjuster
Sodium bicarbonate is used as an antacid (neutralizes stomach acid, NaHCO₃ + HCl → NaCl + H₂O + CO₂) and as a pH adjuster in oral, topical, and parenteral formulations. Intravenous sodium bicarbonate (4.2% and 8.4%) is used for metabolic acidosis correction. It is also used as a leavening agent in food (baking soda).
> Sourcing & Supply
TCS Industries Limited supports development, qualification and commercial purchasing discussions for Sodium Bicarbonate –- Effervescent Agent & Buffering Excipient with buyers in South America, Europe, the United Kingdom, Australia, New Zealand, Mexico and Canada.
- Evaluation and commercial quantities: 25 kg bags for qualification; pallet and bulk for production. Pharmaceutical (USP/Ph.Eur.) and food (FCC) grades in powder and granular forms available.
- Pallet quantities and production campaigns: repeat supply is coordinated against packaging, lead time, annual demand and destination-market import requirements.
> Quality & Documentation
Key specification parameters include assay (≥99.0% NaHCO₃ on dried basis), loss on drying (≤0.25%), insoluble substances, chloride, sulfate, heavy metals (Pb ≤5 ppm), arsenic, calcium, magnesium, iron, and microbial limits. White crystalline powder or granular. Identity by effervescence with acid and sodium flame test. Meets USP, Ph.Eur. (Natrii hydrogenocarbonas), and FCC. COA and MSDS are standard.
> Packaging
Sodium bicarbonate is a white crystalline powder or granular, non-hygroscopic under normal conditions but reacts with moisture in the presence of acid. Standard packaging includes 25 kg or 50 kg polypropylene bags with PE liner, palletized. Store at room temperature in dry conditions. Shelf life is typically 24–36 months. Labels and documents are checked before dispatch.
> Pricing & MOQ
Pricing is quoted by specification, packaging and destination. Common commercial discussions use 25 kg bag/drum formats, pallet quantities and production-campaign planning; smaller samples may be reviewed for qualified formulation teams.
> Regulatory & Compounding Context
Sodium bicarbonate is monographed in USP, Ph.Eur. (Natrii hydrogenocarbonas), BP, and FCC. Listed in the FDA IID for oral, parenteral, topical, and other dosage forms. GRAS in the US (21 CFR 184.1736). No E-number (food ingredient, not classified as food additive in the EU). On the WHO Model List of Essential Medicines (for metabolic acidosis). No special import permits.
> Alias Index
- IUPAC: Sodium hydrogen carbonate
- CAS Number: 144-55-8
- Formula: NaHCO₃ (MW 84.01)
- Common names: Baking soda, Bicarbonate of soda, Sodium hydrogen carbonate
- Pharmacopoeial name: Natrii hydrogenocarbonas (Ph.Eur.)
- Related: Sodium carbonate (Na₂CO₃, soda ash)
- Commercial request terms: sodium bicarbonate USP, baking soda pharma grade, effervescent excipient, NaHCO3, TCS Industries Limited
> FAQ
Why is Sodium Bicarbonate used in effervescent tablets?
NaHCO₃ reacts with organic acids (citric, tartaric) + water → CO₂ gas. This reaction disperses and dissolves the tablet rapidly in water, producing a palatable effervescent solution. The acid-base ratio, particle size, and moisture protection during manufacturing are critical for shelf stability and dissolution performance.
What documents are available for Sodium Bicarbonate –- Effervescent Agent & Buffering Excipient orders?
COA and MSDS are standard for commercial discussions. COO, packing list, invoice and other import-support documents can be arranged according to order scope.
Can TCS Industries Limited support Sodium Bicarbonate –- Effervescent Agent & Buffering Excipient supply to South America?
Yes. We support B2B buyers in Argentina, Colombia, Chile, Peru, Ecuador, Uruguay, Bolivia, Brazil, Paraguay, Venezuela, Guyana and Suriname, subject to route and document review.
Do you support Europe, the United Kingdom, Australia, New Zealand, Mexico and Canada?
Yes. These destinations can be reviewed for project supply, import documents, packaging and logistics planning before quotation.
Is Sodium Bicarbonate used as an IV medication?
Yes. Sodium bicarbonate injection (4.2% and 8.4% solutions) is on the WHO Essential Medicines List for treatment of metabolic acidosis, hyperkalemia, and as a urinary alkalinizer. It must meet parenteral-grade specifications including endotoxin and particulate limits. TCS sources pharmaceutical API-grade material.
What particle size is needed for effervescent tablets?
Fine-grade NaHCO₃ (100–200 mesh) dissolves faster and provides quicker effervescence. Granular grade (40–100 mesh) is easier to handle and less dusty. The particle size is selected based on the required dissolution time, manufacturing process (direct compression vs. wet granulation), and handling requirements.
Can you arrange samples before commercial purchasing?
Samples or evaluation quantities may be reviewed for qualified buyers after target specification, application and destination-market requirements are clarified.
How is Sodium Bicarbonate –- Effervescent Agent & Buffering Excipient packaged for export?
Packaging is confirmed by quantity and material properties. Typical options include foil bags, HDPE containers, fibre drums, 25 kg bags or palletized export packaging.
Can buyer-defined specifications be reviewed?
Yes. Send the specification, methods, impurity limits and required documents. TCS can review feasibility before confirming quotation and lead time.
What payment terms are normally used?
Standard payment is 100% T/T before dispatch unless a different arrangement has been approved for an established commercial account.
What lead time should buyers expect?
Lead time depends on stock, batch size, document scope and destination. Available stock can move faster; made-to-order or pallet programs require longer planning.
Does Sodium Bicarbonate interact with other drugs?
NaHCO₃ raises gastric pH and can affect absorption of pH-dependent drugs (ketoconazole, iron salts, tetracyclines). It also increases urinary pH, affecting renal clearance of weak acids and bases. These interactions are pharmacological, not chemical incompatibilities. Consider timing separation when used with pH-sensitive medications.
Last reviewed: June 2026
Evaluation and research orders (≤10 kg) are shipped with COA, MSDS, and certificate of origin. Bulk commercial orders (>10 kg) qualify for volume pricing with a full technical documentation package available on request.
> Request a Quote
If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.