TCS Industries Limited (China-sourced API supplier) supplies Polyethylene Glycol 4000 -– Tablet Binder, Coating Aid & Osmotic Agent CAS 25322-68-3 for pharmaceutical B2B procurement — COA, MSDS, and technical documentation available on request.
> Overview
| Product Name | Polyethylene Glycol 4000 -– Tablet Binder, Coating Aid & Osmotic Agent |
|---|---|
| Structural Formula |  |
| CAS Number | 25322-68-3 |
| Molecular Formula | H(OC2H4)nOH |
| Molecular Weight | ~4,000 g/mol (n ≈ 91) |
| InChIKey | Not applicable (polydisperse polymer) |
| SMILES | Available on request where applicable |
| Appearance | White, free-flowing powder or flakes |
| Purity / Grade | By agreed specification and batch COA |
| Storage | Keep tightly closed in a cool, dry, well-ventilated place |
PEG 4000 (CAS 25322-68-3) is a polyethylene glycol with an average molecular weight of approximately 4000 Da and the formula H(OCH₂CH₂)ₙOH (n ≈ 90). It is a white, free-flowing waxy solid (melting point 53–58 °C) supplied as flakes, powder, or pastilles. PEG 4000 is used as a suppository base component, tablet coating plasticizer, fusion binder, and osmotic laxative (macrogol 4000) in pharmaceutical formulations.
TCS Industries Limited, a Hong Kong-based trading and sourcing company, supplies PEG 4000 in pharmaceutical (USP-NF/Ph.Eur.) grade for global procurement programs.
> Applications
Osmotic laxative (macrogol 4000)
PEG 4000 (macrogol 4000) is the active ingredient in osmotic laxative preparations (Forlax, Transipeg) for the treatment of chronic constipation. At 10–20 g/day dissolved in water, it increases fecal water content through osmotic retention in the colon without being absorbed or metabolized. Di Palma et al. (Am J Gastroenterol, 2000, 95:446–450) demonstrated the efficacy and safety of PEG 4000 as an osmotic laxative in a randomized controlled trial of chronic constipation.
Tablet coating plasticizer and fusion binder
PEG 4000 is used as a plasticizer in aqueous film coating solutions (with HPMC or other polymers) at 0.5–2.0% of coating solution weight. It improves film flexibility and reduces coating defects. It is also used as a fusion binder in melt granulation and as the firm component in PEG suppository bases.
> Sourcing & Supply
TCS Industries Limited supports development, qualification and commercial purchasing discussions for Polyethylene Glycol 4000 -– Tablet Binder, Coating Aid & Osmotic Agent with buyers in South America, Europe, the United Kingdom, Australia, New Zealand, Mexico and Canada.
- Evaluation and commercial quantities: 5 kg samples; 25 kg bags for production. Pharmaceutical (USP-NF/Ph.Eur.) grade in flakes, powder, or pastille form available.
- Pallet quantities and production campaigns: repeat supply is coordinated against packaging, lead time, annual demand and destination-market import requirements.
> Quality & Documentation
Key specification parameters include average molecular weight (3000–4800), hydroxyl value (25–32 mg KOH/g), pH (4.5–7.5), water content (≤1.0%), residue on ignition (≤0.1%), ethylene glycol and diethylene glycol (≤0.25%), heavy metals (Pb ≤10 ppm), colour, viscosity, and microbial limits. White waxy solid (flakes or powder). Meets USP-NF and Ph.Eur. (Macrogolum 4000). COA and MSDS are standard.
> Packaging
PEG 4000 is a white, free-flowing waxy solid supplied as flakes, powder, or pastilles. Non-hygroscopic under normal conditions. Standard packaging includes 25 kg multiply paper bags with PE liner, palletized. Store at room temperature in dry conditions. Shelf life is typically 24 months. Labels and documents are checked before dispatch.
> Pricing & MOQ
Pricing is quoted by specification, packaging and destination. Common commercial discussions use 25 kg bag/drum formats, pallet quantities and production-campaign planning; smaller samples may be reviewed for qualified formulation teams.
> Regulatory & Compounding Context
PEG 4000 is monographed in USP-NF (Polyethylene Glycol) and Ph.Eur. (Macrogolum 4000). Listed in the FDA IID for oral, topical, rectal, and ophthalmic dosage forms. Macrogol 4000 is approved as an active ingredient for osmotic laxative preparations in the EU and other markets. Approved as a food additive (indirect). GRAS. No special import permits.
> Alias Index
- Chemical class: Polyethylene glycol
- CAS Number: 25322-68-3
- Average MW: ~4000 Da (n ≈ 90)
- Pharmacopoeial name: Macrogolum 4000 (Ph.Eur.), PEG 3350 (USP-NF laxative monograph)
- Physical state: Waxy solid (mp 53–58 °C)
- Brand names (laxative): Forlax, Transipeg, MiraLAX (PEG 3350)
- Commercial request terms: PEG 4000 USP, macrogol 4000 laxative grade, PEG coating plasticizer, suppository base PEG, TCS Industries Limited
> FAQ
What is the difference between PEG 4000 and PEG 3350?
PEG 3350 (MiraLAX in the US) and macrogol 4000 (Forlax in the EU) overlap in molecular weight range (3000–4800 Da). PEG 3350 has a narrower MW distribution centered at 3350 Da. Both are used as osmotic laxatives at similar doses. The choice depends on the pharmacopoeial reference required for your market.
What documents are available for Polyethylene Glycol 4000 -– Tablet Binder, Coating Aid & Osmotic Agent orders?
COA and MSDS are standard for commercial discussions. COO, packing list, invoice and other import-support documents can be arranged according to order scope.
Can TCS Industries Limited support Polyethylene Glycol 4000 -– Tablet Binder, Coating Aid & Osmotic Agent supply to South America?
Yes. We support B2B buyers in Argentina, Colombia, Chile, Peru, Ecuador, Uruguay, Bolivia, Brazil, Paraguay, Venezuela, Guyana and Suriname, subject to route and document review.
Do you support Europe, the United Kingdom, Australia, New Zealand, Mexico and Canada?
Yes. These destinations can be reviewed for project supply, import documents, packaging and logistics planning before quotation.
Is PEG 4000 used as a laxative active ingredient?
Yes. Macrogol 4000 at 10–20 g/day (dissolved in water) is an effective osmotic laxative for chronic constipation and bowel preparation before colonoscopy. It retains water in the colon by osmosis without being absorbed. It is approved as an active pharmaceutical ingredient, not just an excipient, for this indication.
How is PEG 4000 used in film coating?
PEG 4000 is added to aqueous HPMC or PVA coating solutions at 0.5–2.0% as a plasticizer. It reduces glass transition temperature of the film, improves flexibility, reduces cracking, and enhances film adhesion to the tablet core. It replaces volatile plasticizers (propylene glycol, triethyl citrate) in some formulations.
Can you arrange samples before commercial purchasing?
Samples or evaluation quantities may be reviewed for qualified buyers after target specification, application and destination-market requirements are clarified.
How is Polyethylene Glycol 4000 -– Tablet Binder, Coating Aid & Osmotic Agent packaged for export?
Packaging is confirmed by quantity and material properties. Typical options include foil bags, HDPE containers, fibre drums, 25 kg bags or palletized export packaging.
Can buyer-defined specifications be reviewed?
Yes. Send the specification, methods, impurity limits and required documents. TCS can review feasibility before confirming quotation and lead time.
What payment terms are normally used?
Standard payment is 100% T/T before dispatch unless a different arrangement has been approved for an established commercial account.
What lead time should buyers expect?
Lead time depends on stock, batch size, document scope and destination. Available stock can move faster; made-to-order or pallet programs require longer planning.
Can PEG 4000 be used in suppository bases?
Yes. PEG 4000 serves as the high-MW (firm) component in PEG suppository blends. A typical formula: 20% PEG 400 + 50% PEG 1000 + 30% PEG 4000. The ratio is adjusted to achieve the desired hardness and dissolution rate. PEG suppositories dissolve in rectal fluid rather than melting.
Last reviewed: June 2026
Evaluation and research orders (≤10 kg) are shipped with COA, MSDS, and certificate of origin. Bulk commercial orders (>10 kg) qualify for volume pricing with a full technical documentation package available on request.
> Request a Quote
If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.