Polyethylene Glycol 4000: Tablet Binder, Coating Plasticiser and Osmotic Agent
Polyethylene Glycol 4000 (PEG 4000, also known as Macrogol 4000) is a solid-grade polyethylene glycol with an average molecular weight of 3000–4800 Da. It is one of the most commonly used PEG grades in oral solid dosage forms, serving as a binder, film-coating plasticiser, and pore-forming agent in osmotic drug delivery systems. PEG 4000 is also the active ingredient in osmotic laxative preparations.
Product Profile
| CAS Number | 25322-68-3 |
|---|---|
| Appearance | White, free-flowing powder or flakes |
| Function | Binder / coating plasticiser / osmotic agent / laxative |
| Typical Use Level | 5–15% as binder; 0.5–3% as coating plasticiser |
| Compendial Grade | EP / USP-NF / JP |
Formulation Applications
In tablet manufacturing, PEG 4000 functions as a wet or dry binder and improves the mechanical strength of compressed tablets. When added to aqueous film-coating systems based on HPMC or PVA, it acts as a plasticiser that prevents film cracking and improves coating flexibility. In controlled-release osmotic systems, it creates water-soluble pores in semi-permeable membranes. PEG 4000 (Macrogol 4000) is also used directly as an osmotic laxative in sachets and oral solutions, typically dosed at 10–20 g daily. In topical formulation, it forms the solid component of washable PEG ointment bases.
Why Source from TCS
TCS supplies Polyethylene Glycol 4000 in pharmaceutical and technical grades to formulators across Europe. Available in standard packaging with flexible quantities for R&D through production scale. Contact us with your application and volume requirements.
FAQ
What information should be included in an inquiry for Polyethylene Glycol 4000 -25322-68-3?
A useful inquiry normally includes the product name, target application, estimated quantity, destination market, and any specific documentation or packaging requests.
How is Polyethylene Glycol 4000 -25322-68-3 usually evaluated for sourcing?
This product is positioned for excipient sourcing where formulation fit, dosage form, handling, and repeat purchasing requirements need to be reviewed together with commercial supply conditions.
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For excipient sourcing, teams usually discuss the intended dosage form, formulation role, packaging format, order volume, and the routine documentation needed for qualification and purchasing.
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