Polyethylene Glycol 6000: Solid Hydrophilic Excipient for Tablets and Ointments
Polyethylene Glycol 6000 (PEG 6000, Macrogol 6000) is a high-molecular-weight grade with an average Mw of 5400–7400 Da. It is a hard, waxy solid at room temperature with a melting point of approximately 56–63°C. PEG 6000 is valued in formulation for its binding strength, its ability to form rigid suppository and ointment bases, and its use as a carrier in hot-melt extrusion and solid dispersion technologies.
Product Profile
| CAS Number | 25322-68-3 |
|---|---|
| Appearance | White powder or flakes |
| Function | Binder / ointment base component / solid dispersion carrier |
| Typical Use Level | 5–20% as binder; 30–60% in ointment bases |
| Compendial Grade | EP / USP-NF |
Formulation Applications
PEG 6000 is used as a dry binder in tablet formulations, where its higher molecular weight provides stronger inter-particulate bonding than PEG 4000. In suppository and ointment bases, it is the firm component blended with lower-Mw PEGs to control melting point and hardness. Formulators working with hot-melt extrusion use PEG 6000 as a hydrophilic carrier to create amorphous solid dispersions that enhance the dissolution rate of BCS Class II drugs. It also serves as a plasticiser in some film-coating systems at low concentrations.
Why Source from TCS
TCS supplies Polyethylene Glycol 6000 in pharmaceutical and technical grades to formulators across Europe. Available in standard packaging with flexible quantities for R&D through production scale. Contact us with your application and volume requirements.
FAQ
What information should be included in an inquiry for Polyethylene Glycol 6000 –25322-68-3?
A useful inquiry normally includes the product name, target application, estimated quantity, destination market, and any specific documentation or packaging requests.
How is Polyethylene Glycol 6000 –25322-68-3 usually evaluated for sourcing?
This product is positioned for excipient sourcing where formulation fit, dosage form, handling, and repeat purchasing requirements need to be reviewed together with commercial supply conditions.
What documentation and commercial points are commonly reviewed before buying Polyethylene Glycol 6000 –25322-68-3?
For excipient sourcing, teams usually discuss the intended dosage form, formulation role, packaging format, order volume, and the routine documentation needed for qualification and purchasing.
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