TCS Industries Limited (China-sourced API supplier) supplies Microcrystalline Cellulose -– Premium Filler & Binder for Direct Compression CAS 9004-34-6 for pharmaceutical B2B procurement — COA, MSDS, and technical documentation available on request.
> Overview
| Product Name | Microcrystalline Cellulose -– Premium Filler & Binder for Direct Compression |
|---|---|
| Structural Formula |  |
| CAS Number | 9004-34-6 |
| Molecular Formula | (C6H10O5)n |
| Molecular Weight | Grade-dependent (typ. 36,000 g/mol) |
| InChIKey | Not applicable (polydisperse polymer) |
| SMILES | Available on request where applicable |
| Appearance | White, odourless, free-flowing powder or granules |
| Purity / Grade | By agreed specification and batch COA |
| Storage | Keep tightly closed in a cool, dry, well-ventilated place |
Microcrystalline Cellulose (CAS 9004-34-6, MCC) is a purified, partially depolymerized cellulose prepared by treating wood pulp with mineral acid. MCC is a white, odorless, free-flowing powder used as a tablet binder-diluent, disintegrant, adsorbent, and anti-caking agent. It is the second most used pharmaceutical excipient (after lactose) and enables direct compression tableting with excellent compactability.
TCS Industries Limited, a Hong Kong-based trading and sourcing company, supplies Microcrystalline Cellulose in multiple particle size grades for pharmaceutical and food procurement programs.
> Applications
Direct compression binder-diluent
MCC is the preferred binder-filler for direct compression tableting due to its plastic deformation under pressure, creating strong inter-particle bonds without granulation. Different grades (PH-101, PH-102, PH-200, PH-301, PH-302) vary in particle size and density to suit different formulation needs. Doelker et al. (Powder Technol, 1995, 85:13–25) studied the compaction mechanisms of MCC including hydrogen bonding and mechanical interlocking at the particle level.
Wet granulation binder and capsule filler
MCC is used as a binder in wet granulation processes and as a filler in hard capsule formulations. Granular grades (PH-200, ~200 µm) improve flow for capsule filling. Silicified MCC (co-processed with colloidal silica) provides enhanced flow and moisture resistance for direct compression of moisture-sensitive APIs.
> Sourcing & Supply
TCS Industries Limited supports development, qualification and commercial purchasing discussions for Microcrystalline Cellulose -– Premium Filler & Binder for Direct Compression with buyers in South America, Europe, the United Kingdom, Australia, New Zealand, Mexico and Canada.
- Evaluation and commercial quantities: 5 kg samples for formulation trials; 20 kg or 25 kg bags for production. PH-101, PH-102, PH-200, PH-301, PH-302, and silicified grades available.
- Pallet quantities and production campaigns: repeat supply is coordinated against packaging, lead time, annual demand and destination-market import requirements.
> Quality & Documentation
Key specification parameters include degree of polymerization (DP ≤350), loss on drying (≤7.0%), residue on ignition (≤0.05%), water-soluble substances, heavy metals (Pb ≤10 ppm), ether-soluble substances, particle size distribution (grade-specific: PH-101 ~50 µm, PH-102 ~100 µm, PH-200 ~200 µm), bulk density, tapped density, and microbial limits. White, odorless powder. Meets USP-NF, Ph.Eur. (Cellulosum microcristallinum), and JP. COA and MSDS are standard.
> Packaging
MCC is a white, odorless, free-flowing powder. Hygroscopic at high humidity. Standard packaging includes 20 kg or 25 kg multiply paper bags with PE liner, palletized and shrink-wrapped. Store at room temperature in dry conditions (≤65% RH). Shelf life is typically 36 months. Labels and documents are checked before dispatch.
> Pricing & MOQ
Pricing is quoted by specification, packaging and destination. Common commercial discussions use 25 kg bag/drum formats, pallet quantities and production-campaign planning; smaller samples may be reviewed for qualified formulation teams.
> Regulatory & Compounding Context
MCC is monographed in USP-NF (Microcrystalline Cellulose), Ph.Eur. (Cellulosum microcristallinum), BP, and JP. Approved as a food additive in the EU (E460(i)). GRAS in the US. Listed in the FDA IID for oral and topical dosage forms. No ADI specified. No special import permits.
> Alias Index
- Chemical class: Partially depolymerized cellulose
- CAS Number: 9004-34-6
- Abbreviation: MCC
- EU food additive: E460(i)
- Pharmacopoeial name: Cellulosum microcristallinum (Ph.Eur.)
- Grade system: PH-101 (50 µm), PH-102 (100 µm), PH-200 (200 µm), PH-301/302 (high density)
- Brand equivalents: Avicel (DuPont/IFF), Vivapur (JRS Pharma), Emcocel (JRS)
- Commercial request terms: MCC PH-102, microcrystalline cellulose USP, Avicel equivalent, direct compression filler, E460, TCS Industries Limited
> FAQ
Which MCC grade should I use?
PH-101 (50 µm): best compactability, used in wet granulation and small tablets. PH-102 (100 µm): standard for direct compression, good balance of flow and compactability. PH-200 (200 µm): best flow, used for capsule filling and large tablets. PH-301/302: high-density grades for reducing tablet size. Specify grade at inquiry.
What documents are available for Microcrystalline Cellulose -– Premium Filler & Binder for Direct Compression orders?
COA and MSDS are standard for commercial discussions. COO, packing list, invoice and other import-support documents can be arranged according to order scope.
Can TCS Industries Limited support Microcrystalline Cellulose -– Premium Filler & Binder for Direct Compression supply to South America?
Yes. We support B2B buyers in Argentina, Colombia, Chile, Peru, Ecuador, Uruguay, Bolivia, Brazil, Paraguay, Venezuela, Guyana and Suriname, subject to route and document review.
Do you support Europe, the United Kingdom, Australia, New Zealand, Mexico and Canada?
Yes. These destinations can be reviewed for project supply, import documents, packaging and logistics planning before quotation.
Can MCC replace Lactose in tablet formulations?
MCC can replace lactose as a filler-binder. MCC has superior compactability, is non-cariogenic, and is lactose-free (suitable for lactose-intolerant patients). However, MCC is hygroscopic and has lower density than lactose. MCC-lactose blends are common to optimize both compactability and flow/density properties.
What is silicified MCC?
Silicified MCC (SMCC) is co-processed MCC with 2% colloidal silicon dioxide. It has improved flow, compactability, and moisture resistance compared to standard MCC. SMCC enables direct compression of moisture-sensitive and poorly flowing formulations. Prosolv (JRS) is a commercial SMCC brand. Specify SMCC if required.
Can you arrange samples before commercial purchasing?
Samples or evaluation quantities may be reviewed for qualified buyers after target specification, application and destination-market requirements are clarified.
How is Microcrystalline Cellulose -– Premium Filler & Binder for Direct Compression packaged for export?
Packaging is confirmed by quantity and material properties. Typical options include foil bags, HDPE containers, fibre drums, 25 kg bags or palletized export packaging.
Can buyer-defined specifications be reviewed?
Yes. Send the specification, methods, impurity limits and required documents. TCS can review feasibility before confirming quotation and lead time.
What payment terms are normally used?
Standard payment is 100% T/T before dispatch unless a different arrangement has been approved for an established commercial account.
What lead time should buyers expect?
Lead time depends on stock, batch size, document scope and destination. Available stock can move faster; made-to-order or pallet programs require longer planning.
Is MCC derived from wood or cotton?
Pharmaceutical MCC is produced from refined wood pulp (softwood or hardwood) by controlled acid hydrolysis. Cotton-derived MCC exists but is less common. The source does not significantly affect pharmaceutical properties when material meets pharmacopoeial specifications. All commercial sources are plant-based (vegetarian, non-GMO).
Last reviewed: June 2026
Evaluation and research orders (≤10 kg) are shipped with COA, MSDS, and certificate of origin. Bulk commercial orders (>10 kg) qualify for volume pricing with a full technical documentation package available on request.
> Request a Quote
If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.