Microcrystalline Cellulose (MCC): The Gold Standard Filler-Binder for Direct Compression
Microcrystalline cellulose (MCC) is a purified, partially depolymerized cellulose derived from wood pulp. It is the most important filler-binder for direct compression tableting and has become a foundational excipient in modern solid dosage form development. Its exceptional compressibility, low lubricant sensitivity, and compatibility with virtually all APIs make it the first-choice diluent for most formulators.
Product Profile
| CAS Number | 9004-34-6 |
|---|---|
| Appearance | White, odourless, free-flowing powder or granules |
| Function | Filler / binder / disintegrant / adsorbent |
| Typical Use Level | 20–90% w/w as filler-binder in tablets |
| Compendial Grade | EP / USP-NF / JP |
Formulation Applications
MCC is available in multiple grades defined by particle size and moisture content. The most common pharmaceutical grade (equivalent to Avicel PH-102, ~100 µm) provides the optimal balance of flowability and compressibility for direct compression. Finer grades (~50 µm, PH-101 type) offer higher compressibility but poorer flow and are suited for wet granulation. Coarser grades (PH-200, ~180 µm) provide improved flow for high-speed tableting. MCC deforms plastically under compression, forming strong hydrogen bonds between particles — this is the basis of its exceptional binding properties. It also contributes to tablet disintegration through moisture wicking and swelling. Silicified MCC grades (co-processed with colloidal silicon dioxide) offer enhanced flow for poorly flowing blends. MCC absorbs up to 12% moisture in equilibrium with typical ambient conditions without adverse effects on tableting performance.
Why Source from TCS
TCS supplies microcrystalline cellulose in multiple pharmaceutical grades to formulators across Europe. Available in standard packaging with flexible quantities for R&D through production scale. Contact us with your grade requirements and volume needs.
FAQ
What information should be included in an inquiry for Microcrystalline Cellulose -9004-34-6?
A useful inquiry normally includes the product name, target application, estimated quantity, destination market, and any specific documentation or packaging requests.
How is Microcrystalline Cellulose -9004-34-6 usually evaluated for sourcing?
This product is positioned for excipient sourcing where formulation fit, dosage form, handling, and repeat purchasing requirements need to be reviewed together with commercial supply conditions.
What documentation and commercial points are commonly reviewed before buying Microcrystalline Cellulose -9004-34-6?
For excipient sourcing, teams usually discuss the intended dosage form, formulation role, packaging format, order volume, and the routine documentation needed for qualification and purchasing.
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