N,N-Dimethylacetamide (DMAc): High-Boiling Polar Aprotic Solvent
N,N-Dimethylacetamide is a powerful polar aprotic solvent with a high boiling point of 165°C and complete miscibility with water and most organic solvents. It is widely used in pharmaceutical synthesis as a reaction medium for difficult transformations, and in polymer processing — particularly for dissolving polyimides, polyamides, and polyurethanes. Its strong solvating power and thermal stability make it a preferred choice where lower-boiling solvents such as DMF fall short.
Product Profile
| CAS Number | 127-19-5 |
|---|---|
| Molecular Formula | C₄H₉NO |
| Appearance | Colourless liquid with a faint amine-like odour |
| Function | Polar aprotic solvent / reaction medium |
| Boiling Point | 165°C |
Formulation Applications
DMAc serves as a process solvent in the synthesis of active pharmaceutical ingredients where high solvating power and elevated reaction temperatures are needed. In polymer science, it is the standard solvent for spinning polyimide and aramid fibres. It is also used to dissolve and process specialty coatings, membranes, and films. Formulators value its ability to keep heat-sensitive intermediates in solution during controlled crystallisation steps.
Why Source from TCS
TCS supplies N,N-Dimethylacetamide in pharmaceutical and technical grades to chemical and pharmaceutical companies across Europe. Available in drums and IBCs with flexible quantities for R&D through production scale. Contact us with your application and volume requirements.
FAQ
What information should be included in an inquiry for N,N-Dimethylacetamide –127-19-5?
A useful inquiry normally includes the product name, target application, estimated quantity, destination market, and any specific documentation or packaging requests.
How is N,N-Dimethylacetamide –127-19-5 usually evaluated for sourcing?
This product is positioned for excipient sourcing where formulation fit, dosage form, handling, and repeat purchasing requirements need to be reviewed together with commercial supply conditions.
What documentation and commercial points are commonly reviewed before buying N,N-Dimethylacetamide –127-19-5?
For excipient sourcing, teams usually discuss the intended dosage form, formulation role, packaging format, order volume, and the routine documentation needed for qualification and purchasing.
Request a Quote
If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.