Mannitol: Non-Hygroscopic Filler and Sweetener for Solid Dosage Forms
Mannitol is a six-carbon sugar alcohol that stands out among pharmaceutical fillers for its non-hygroscopic nature, pleasant sweet taste (approximately 50–70% of sucrose sweetness), and characteristic cooling sensation upon dissolution. It is the excipient of choice for orally disintegrating tablets (ODTs) and moisture-sensitive formulations where stability is compromised by water uptake.
Product Profile
| CAS Number | 87-78-5 |
|---|---|
| Molecular Formula | C₆H₁₄O₆ |
| Appearance | White crystalline powder or granules |
| Function | Filler / sweetener / tonicity agent / carrier |
| Typical Use Level | 10–90% w/w as tablet filler; 5–20% in lyophilized products |
| Compendial Grade | EP / USP-NF / JP |
Formulation Applications
Mannitol is available in several forms optimized for different processes: spray-dried mannitol for direct compression, granular mannitol for roller compaction, and powder mannitol for wet granulation. Spray-dried grades offer excellent flow and compressibility for direct compression, particularly in ODT formulations where rapid oral disintegration and pleasant taste are critical. Mannitol is the preferred bulking agent in freeze-dried (lyophilized) parenteral products because it forms a crystalline matrix that provides an elegant cake with excellent reconstitution properties. As an osmotic agent, it is used intravenously (10–20% solutions) for reduction of intracranial and intraocular pressure. Its non-hygroscopic character (moisture uptake less than 1% at 90% RH) makes it superior to lactose for moisture-sensitive APIs.
Why Source from TCS
TCS supplies mannitol in pharmaceutical and food grades (powder, granular, and spray-dried) to formulators across Europe. Available in standard packaging with flexible quantities for R&D through production scale. Contact us with your grade requirements and volume needs.
FAQ
What information should be included in an inquiry for Mannitol -87-78-5?
A useful inquiry normally includes the product name, target application, estimated quantity, destination market, and any specific documentation or packaging requests.
How is Mannitol -87-78-5 usually evaluated for sourcing?
This product is positioned for excipient sourcing where formulation fit, dosage form, handling, and repeat purchasing requirements need to be reviewed together with commercial supply conditions.
What documentation and commercial points are commonly reviewed before buying Mannitol -87-78-5?
For excipient sourcing, teams usually discuss the intended dosage form, formulation role, packaging format, order volume, and the routine documentation needed for qualification and purchasing.
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If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.