TCS Industries Limited (China-sourced API supplier) supplies Mannitol -– Non-Hygroscopic Filler & Sweetener for Solid Dosage Forms CAS 87-78-5 for pharmaceutical B2B procurement — COA, MSDS, and technical documentation available on request.
> Overview
| Product Name | Mannitol -– Non-Hygroscopic Filler & Sweetener for Solid Dosage Forms |
|---|---|
| Structural Formula |  |
| CAS Number | 87-78-5 |
| Molecular Formula | C₆H₁₄O₆ |
| Molecular Weight | 182.17 g/mol |
| InChIKey | FBPFZTCFMRRESA-KVTDHHQDSA-N |
| SMILES | Available on request where applicable |
| Appearance | White crystalline powder or granules |
| Purity / Grade | By agreed specification and batch COA |
| Storage | Keep tightly closed in a cool, dry, well-ventilated place |
Mannitol (CAS 87-78-5) is a six-carbon sugar alcohol (polyol) with the formula C₆H₁₄O₆ (MW 182.17), isomeric with sorbitol. It is produced by catalytic hydrogenation of fructose-glucose mixtures or by fermentation. Mannitol is used as a pharmaceutical excipient (tablet diluent, lyophilization bulking agent), osmotic diuretic, and diagnostic agent for renal function assessment. It provides 1.6 kcal/g and approximately 50% of sucrose sweetness.
TCS Industries Limited, a Hong Kong-based trading and sourcing company, supplies Mannitol in pharmaceutical (USP/Ph.Eur.) and food grades for global procurement programs.
> Applications
Tablet diluent and lyophilization bulking agent
Mannitol is used as a filler in chewable tablets (cool mouthfeel, pleasant sweetness) and as a bulking agent in lyophilized (freeze-dried) injectable and biologic products. Its crystalline structure during freeze-drying provides an elegant cake with good reconstitution properties. Spray-dried mannitol (Pearlitol SD, Mannogem equivalent) is engineered for direct compression. Pikal et al. (J Pharm Sci, 2004, 93:981–994) studied the lyophilization behavior of mannitol including polymorphic transitions and their impact on cake structure.
Osmotic diuretic and diagnostic agent
Intravenous mannitol (15–25% solution) is used as an osmotic diuretic to reduce intracranial pressure (cerebral edema) and intraocular pressure, promote renal excretion of toxic substances, and assess renal function (mannitol clearance = GFR). It is on the WHO Model List of Essential Medicines.
> Sourcing & Supply
TCS Industries Limited supports development, qualification and commercial purchasing discussions for Mannitol -– Non-Hygroscopic Filler & Sweetener for Solid Dosage Forms with buyers in South America, Europe, the United Kingdom, Australia, New Zealand, Mexico and Canada.
- Evaluation and commercial quantities: 25 kg bags for qualification; pallet for production. Crystalline, spray-dried (direct compression), and granular forms in pharmaceutical and food grades available. Injectable grade on request.
- Pallet quantities and production campaigns: repeat supply is coordinated against packaging, lead time, annual demand and destination-market import requirements.
> Quality & Documentation
Key specification parameters include assay (≥98.0% D-mannitol by HPLC), sorbitol content (≤2.0%), other polyols, loss on drying (≤0.5%), residue on ignition (≤0.1%), heavy metals (Pb ≤0.5 ppm), nickel, pH, conductivity, endotoxins (for injectable-grade), and microbial limits. White crystalline powder or granular. Meets USP-NF, Ph.Eur. (Mannitolum), and JP. COA and MSDS are standard.
> Packaging
Mannitol is a white, free-flowing crystalline powder, non-hygroscopic. Standard packaging includes 25 kg multiply paper bags with PE liner, palletized and shrink-wrapped. Store at room temperature in dry conditions. Shelf life is typically 36 months. Labels and documents are checked before dispatch.
> Pricing & MOQ
Pricing is quoted by specification, packaging and destination. Common commercial discussions use 25 kg bag/drum formats, pallet quantities and production-campaign planning; smaller samples may be reviewed for qualified formulation teams.
> Regulatory & Compounding Context
Mannitol is monographed in USP-NF, Ph.Eur. (Mannitolum), BP, JP, and FCC. Approved as a food additive in the EU (E421, quantum satis). GRAS in the US. Listed in the FDA IID for oral, parenteral, inhalation, and other dosage forms. On the WHO Model List of Essential Medicines (osmotic diuretic). ADI: not specified (JECFA). No special import permits.
> Alias Index
- IUPAC: D-Mannitol
- CAS Number: 87-78-5
- Formula: C₆H₁₄O₆ (MW 182.17)
- EU food additive: E421
- Sweetness: ~50% of sucrose
- Pharmacopoeial name: Mannitolum (Ph.Eur.)
- Brand equivalents: Pearlitol (Roquette), Mannogem (SPI Pharma), Parteck M (Merck)
- Commercial request terms: mannitol USP, D-mannitol pharma grade, spray-dried mannitol DC, lyophilization bulking agent, E421, TCS Industries Limited
> FAQ
Why is Mannitol preferred for chewable tablets?
Mannitol produces a cooling sensation in the mouth (negative heat of solution), has a clean sweet taste (~50% of sucrose), is non-cariogenic, and is non-hygroscopic (maintaining tablet quality). These properties make it the preferred diluent for chewable and sublingual tablets. Sorbitol is an alternative but is hygroscopic.
What documents are available for Mannitol -– Non-Hygroscopic Filler & Sweetener for Solid Dosage Forms orders?
COA and MSDS are standard for commercial discussions. COO, packing list, invoice and other import-support documents can be arranged according to order scope.
Can TCS Industries Limited support Mannitol -– Non-Hygroscopic Filler & Sweetener for Solid Dosage Forms supply to South America?
Yes. We support B2B buyers in Argentina, Colombia, Chile, Peru, Ecuador, Uruguay, Bolivia, Brazil, Paraguay, Venezuela, Guyana and Suriname, subject to route and document review.
Do you support Europe, the United Kingdom, Australia, New Zealand, Mexico and Canada?
Yes. These destinations can be reviewed for project supply, import documents, packaging and logistics planning before quotation.
What Mannitol grade is used for lyophilization?
Standard crystalline mannitol (USP/Ph.Eur.) is used as a bulking agent in lyophilized formulations at 2–5% w/v. It crystallizes during freeze-drying, providing cake structure and elegance. Mannitol can exist in polymorphic forms (alpha, beta, delta); the beta polymorph is most stable. An annealing step during lyophilization ensures complete crystallization.
Is Mannitol non-hygroscopic?
Yes. Mannitol is effectively non-hygroscopic — it does not absorb moisture below 90% RH. This is a key advantage over sorbitol (hygroscopic above 65% RH) and lactose (hygroscopic above 80% RH). Non-hygroscopic behavior helps maintain tablet hardness and stability during storage.
Can you arrange samples before commercial purchasing?
Samples or evaluation quantities may be reviewed for qualified buyers after target specification, application and destination-market requirements are clarified.
How is Mannitol -– Non-Hygroscopic Filler & Sweetener for Solid Dosage Forms packaged for export?
Packaging is confirmed by quantity and material properties. Typical options include foil bags, HDPE containers, fibre drums, 25 kg bags or palletized export packaging.
Can buyer-defined specifications be reviewed?
Yes. Send the specification, methods, impurity limits and required documents. TCS can review feasibility before confirming quotation and lead time.
What payment terms are normally used?
Standard payment is 100% T/T before dispatch unless a different arrangement has been approved for an established commercial account.
What lead time should buyers expect?
Lead time depends on stock, batch size, document scope and destination. Available stock can move faster; made-to-order or pallet programs require longer planning.
Can Mannitol be used for direct compression?
Spray-dried mannitol (Pearlitol SD/Mannogem equivalent) is engineered for direct compression with controlled particle size and flowability. Standard crystalline mannitol has poor compressibility and requires granulation. Specify “spray-dried direct compression grade” at inquiry for DC applications.
Last reviewed: June 2026
Evaluation and research orders (≤10 kg) are shipped with COA, MSDS, and certificate of origin. Bulk commercial orders (>10 kg) qualify for volume pricing with a full technical documentation package available on request.
> Request a Quote
If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.