Hypromellose (HPMC): Film Former, Binder, and Controlled-Release Polymer
Hypromellose (hydroxypropyl methylcellulose, HPMC) is a non-ionic, water-soluble cellulose ether that is arguably the most versatile polymer in pharmaceutical formulation. Its range of viscosity grades and substitution types makes it suitable for film coating, wet granulation binding, controlled-release matrix formation, and ophthalmic viscosity building — often within a single product line.
Product Profile
| CAS Number | 9004-65-3 |
|---|---|
| Appearance | White to off-white fibrous or granular powder |
| Function | Film former / binder / controlled-release matrix / thickener |
| Typical Use Level | 2–5% as binder; 2–4% for film coating; 10–80% in matrix tablets |
| Compendial Grade | EP / USP-NF / JP |
Formulation Applications
For film coating, low-viscosity HPMC grades (e.g., HPMC 2910, 3–15 cps) are used at 2–4% in aqueous coating solutions, often with plasticizers such as PEG 400 or triethyl citrate. As a wet granulation binder, HPMC at 2–5% in granulating fluid produces granules with good compressibility. For controlled-release matrices, high-viscosity grades (HPMC 2208, 4000–100,000 cps) at 20–40% form a hydrophilic gel layer upon contact with gastrointestinal fluids, controlling drug release over 8–24 hours. HPMC is also the polymer of choice for vegetarian (non-gelatin) capsule shells. Its non-ionic nature gives it broad pH-independent performance and compatibility with most APIs and excipients.
Why Source from TCS
TCS supplies hypromellose in multiple substitution types and viscosity grades to pharmaceutical formulators across Europe. Available in standard packaging with flexible quantities for R&D through production scale. Contact us with your grade requirements and volume needs.
FAQ
What information should be included in an inquiry for Hypromellose (HPMC) –9004-65-3?
A useful inquiry normally includes the product name, target application, estimated quantity, destination market, and any specific documentation or packaging requests.
How is Hypromellose (HPMC) –9004-65-3 usually evaluated for sourcing?
This product is positioned for excipient sourcing where formulation fit, dosage form, handling, and repeat purchasing requirements need to be reviewed together with commercial supply conditions.
What documentation and commercial points are commonly reviewed before buying Hypromellose (HPMC) –9004-65-3?
For excipient sourcing, teams usually discuss the intended dosage form, formulation role, packaging format, order volume, and the routine documentation needed for qualification and purchasing.
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If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.