TCS Industries Limited (China-sourced API supplier) supplies Heptane –- High-Purity Nonpolar Solvent for Extraction & Synthesis CAS 142-82-5 for pharmaceutical B2B procurement — COA, MSDS, and technical documentation available on request.
> Overview
| Product Name | Heptane –- High-Purity Nonpolar Solvent for Extraction & Synthesis |
|---|---|
| Structural Formula |  |
| CAS Number | 142-82-5 |
| Molecular Formula | C₇H₁₆ |
| Molecular Weight | 100.2 g/mol |
| InChIKey | IMNFDUFMRHMDMM-UHFFFAOYSA-N |
| SMILES | Available on request where applicable |
| Appearance | Clear, colourless liquid with a mild petroleum-like odour |
| Purity / Grade | By agreed specification and batch COA |
| Storage | Keep tightly closed in a cool, dry, well-ventilated place |
Heptane (CAS 142-82-5) is a straight-chain alkane hydrocarbon with the formula C₇H₁₆ (MW 100.20). It is a colorless, volatile liquid with a gasoline-like odor, immiscible with water. N-heptane is the reference fuel for octane rating determination (octane number = 0) and is widely used as an extraction solvent, chromatography mobile phase component, and reaction medium in pharmaceutical and chemical manufacturing.
TCS Industries Limited, a Hong Kong-based trading and sourcing company, supplies Heptane in technical, HPLC, and ACS reagent grades for global procurement programs.
> Applications
Pharmaceutical extraction and crystallization solvent
N-heptane is an ICH Class 3 solvent (low toxic potential, PDE 50 mg/day) widely used in pharmaceutical API manufacturing for extraction, crystallization, and purification processes. It is preferred over hexane for pharmaceutical applications due to lower neurotoxicity risk (n-hexane is ICH Class 2). The low polarity and defined boiling point (98 °C) make it suitable for controlled crystallization. Grodowska et al. (Acta Pol Pharm, 2010, 67:3–12) reviewed ICH solvent classification and selection criteria for pharmaceutical manufacturing.
Laboratory and chromatography solvent
HPLC-grade n-heptane is used as a normal-phase chromatography mobile phase component and as a reference standard for octane number testing (RON/MON). ACS reagent-grade material is used for general laboratory extraction and cleaning applications.
> Sourcing & Supply
TCS Industries Limited supports development, qualification and commercial purchasing discussions for Heptane –- High-Purity Nonpolar Solvent for Extraction & Synthesis with buyers in South America, Europe, the United Kingdom, Australia, New Zealand, Mexico and Canada.
- Evaluation and commercial quantities: 25 L cans for qualification; 200 L drums and IBC for production. Technical, ACS reagent, HPLC, and pharma grades available.
- Pallet quantities and production campaigns: repeat supply is coordinated against packaging, lead time, annual demand and destination-market import requirements.
> Quality & Documentation
Key specification parameters include assay (≥99.0% for technical, ≥99.0% for HPLC, ≥99.0% for ACS), water content (≤0.01% for HPLC), residue on evaporation, UV cutoff (HPLC grade: ≤200 nm), acidity, sulfur, thiophene (petroleum-derived), and specific gravity (0.683–0.684). HPLC grade requires fluorescence and UV absorbance testing. COA and MSDS are standard.
> Packaging
Heptane is a highly flammable liquid (flash point -4 °C) and must be stored in approved flammable-liquid storage areas away from ignition sources. Standard packaging includes 200 L steel drums (UN-rated) and 1000 L IBC. Transport as UN 1206, Class 3, PG II with DGD documentation. Labels and documents are checked before dispatch.
> Pricing & MOQ
Pricing is quoted by specification, packaging and destination. Common commercial discussions use 25 kg bag/drum formats, pallet quantities and production-campaign planning; smaller samples may be reviewed for qualified formulation teams.
> Regulatory & Compounding Context
N-heptane is classified as ICH Class 3 solvent (low toxic potential) for pharmaceutical manufacturing. REACH-registered. Classified as Flammable Liquid Category 2 (H225, flash point -4 °C), Aspiration Hazard Category 1 (H304), and STOT SE 3 (H336). Transport: UN 1206, Class 3, PG II. OEL: 400 ppm (8h TWA, ACGIH TLV). Buyers must confirm local solvent emission and safety regulations.
> Alias Index
- IUPAC: Heptane
- CAS Number: 142-82-5
- Formula: C₇H₁₆ (MW 100.20)
- Common names: n-Heptane, Normal heptane, Dipropylmethane
- Physical properties: b.p. 98.4 °C, flash point -4 °C, density 0.684 g/mL
- ICH classification: Class 3 (low toxic potential, PDE 50 mg/day)
- Transport: UN 1206, Class 3, PG II
- InChIKey: IMNFDUFMRHMDMM-UHFFFAOYSA-N
- Commercial request terms: n-heptane pharma grade, heptane HPLC, extraction solvent ICH Class 3, TCS Industries Limited
> FAQ
Why is n-heptane preferred over n-hexane for pharmaceutical use?
N-heptane is ICH Class 3 (low toxic potential, PDE 50 mg/day). N-hexane is ICH Class 2 with a lower PDE (2.9 mg/day) due to neurotoxicity risk (metabolite 2,5-hexanedione causes peripheral neuropathy). Pharmaceutical manufacturers increasingly substitute heptane for hexane in extraction and crystallization.
What documents are available for Heptane –- High-Purity Nonpolar Solvent for Extraction & Synthesis orders?
COA and MSDS are standard for commercial discussions. COO, packing list, invoice and other import-support documents can be arranged according to order scope.
Can TCS Industries Limited support Heptane –- High-Purity Nonpolar Solvent for Extraction & Synthesis supply to South America?
Yes. We support B2B buyers in Argentina, Colombia, Chile, Peru, Ecuador, Uruguay, Bolivia, Brazil, Paraguay, Venezuela, Guyana and Suriname, subject to route and document review.
Do you support Europe, the United Kingdom, Australia, New Zealand, Mexico and Canada?
Yes. These destinations can be reviewed for project supply, import documents, packaging and logistics planning before quotation.
Is Heptane classified as dangerous goods?
Yes. N-heptane is UN 1206, Class 3 Flammable Liquid, Packing Group II (flash point -4 °C). It is also classified as an aspiration hazard (H304). Transport requires UN-rated packaging and DGD documentation.
What is the relationship between Heptane and octane number?
N-heptane defines octane number 0 (zero) on the RON/MON scale. Isooctane (2,2,4-trimethylpentane) defines 100. The octane number of a fuel is determined by comparison to n-heptane/isooctane reference blends. High-purity n-heptane is used as a reference standard for octane testing.
Can you arrange samples before commercial purchasing?
Samples or evaluation quantities may be reviewed for qualified buyers after target specification, application and destination-market requirements are clarified.
How is Heptane –- High-Purity Nonpolar Solvent for Extraction & Synthesis packaged for export?
Packaging is confirmed by quantity and material properties. Typical options include foil bags, HDPE containers, fibre drums, 25 kg bags or palletized export packaging.
Can buyer-defined specifications be reviewed?
Yes. Send the specification, methods, impurity limits and required documents. TCS can review feasibility before confirming quotation and lead time.
What payment terms are normally used?
Standard payment is 100% T/T before dispatch unless a different arrangement has been approved for an established commercial account.
What lead time should buyers expect?
Lead time depends on stock, batch size, document scope and destination. Available stock can move faster; made-to-order or pallet programs require longer planning.
What grades does TCS supply?
TCS sources technical grade (≥99%), ACS reagent grade, HPLC grade (low UV absorbance, controlled water), and pharmaceutical grade (ICH Class 3 compliant). Specify the intended application and analytical requirements at inquiry.
Last reviewed: June 2026
Evaluation and research orders (≤10 kg) are shipped with COA, MSDS, and certificate of origin. Bulk commercial orders (>10 kg) qualify for volume pricing with a full technical documentation package available on request.
> Request a Quote
If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.