Heptane: High-Purity Nonpolar Solvent
Heptane (n-heptane) is a seven-carbon saturated hydrocarbon used as a nonpolar solvent in pharmaceutical synthesis, extraction, and analytical laboratories. It is classified as an ICH Class 3 solvent (low toxic potential), making it a preferred alternative to hexane for pharmaceutical applications where residual solvent limits are a regulatory concern.
Product Profile
| CAS Number | 142-82-5 |
|---|---|
| Molecular Formula | C₇H₁₆ |
| Appearance | Clear, colourless liquid with a mild petroleum-like odour |
| Function | Process solvent / extraction solvent / reaction medium |
Formulation Applications
In pharmaceutical manufacturing, heptane is used as a crystallization solvent, reaction medium, and extraction solvent during API synthesis. Its ICH Class 3 status (PDE of 50 mg/day) gives it a significant regulatory advantage over n-hexane (Class 2, PDE 2.9 mg/day), and it can often serve as a drop-in replacement in processes previously using hexane. In analytical chemistry, heptane is used as a mobile phase component in normal-phase HPLC and as a reference standard for octane number determination. It is highly flammable (flash point approximately -4°C) and must be handled with appropriate precautions. Heptane is immiscible with water and miscible with most organic solvents.
Why Source from TCS
TCS supplies heptane in HPLC, analytical, and technical grades to pharmaceutical and chemical companies across Europe. Available in standard packaging with flexible quantities. Contact us with your purity requirements and volume needs.
FAQ
What information should be included in an inquiry for Heptane –142-82-5?
A useful inquiry normally includes the product name, target application, estimated quantity, destination market, and any specific documentation or packaging requests.
How is Heptane –142-82-5 usually evaluated for sourcing?
This product is positioned for excipient sourcing where formulation fit, dosage form, handling, and repeat purchasing requirements need to be reviewed together with commercial supply conditions.
What documentation and commercial points are commonly reviewed before buying Heptane –142-82-5?
For excipient sourcing, teams usually discuss the intended dosage form, formulation role, packaging format, order volume, and the routine documentation needed for qualification and purchasing.
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