TCS Industries Limited (China-sourced API supplier) supplies Diphemanil Methylsulfate — API CAS 62-97-5 for pharmaceutical B2B procurement — COA, MSDS, and technical documentation available on request.
> Overview
| Product Name | Diphemanil Methylsulfate |
|---|---|
| Structural Formula |  |
| CAS Number | 62-97-5 |
| Molecular Formula | C21H27NO4S |
| Molecular Weight | 389.5 g/mol |
| InChIKey | BREMLQBSKCSNNH-UHFFFAOYSA-M |
| SMILES | Available on request where applicable |
| Appearance | White to off-white crystalline powder |
| Purity / Grade | By agreed specification and batch COA |
| Storage | Store at controlled room temperature |
Diphemanil Methylsulfate (CAS 62-97-5) is a quaternary ammonium anticholinergic agent with the formula C₂₁H₂₅NO₄S (MW 389.49). It blocks muscarinic acetylcholine receptors and has been used as an antisecretory and antispasmodic agent. Diphemanil methylsulfate reduces sweat gland activity and has been applied in hyperhidrosis management and as a gastrointestinal antispasmodic.
TCS Industries Limited, a Hong Kong-based trading and sourcing company, supplies Diphemanil Methylsulfate API for pharmaceutical procurement programs.
> Applications
Anticholinergic for hyperhidrosis
Diphemanil methylsulfate is applied topically or administered orally to reduce sweat gland activity by blocking muscarinic receptors on eccrine glands. It has been used in dermatological formulations for focal hyperhidrosis. Bajaj et al. (Indian J Dermatol Venereol Leprol, 2009, 75:463–468) evaluated topical anticholinergic agents including diphemanil for management of primary focal hyperhidrosis.
Gastrointestinal antispasmodic
As a quaternary ammonium compound, diphemanil methylsulfate has poor blood-brain barrier penetration, limiting CNS side effects. It was used as a GI antispasmodic for peptic ulcer and functional bowel disorders. Its quaternary structure also makes it suitable for topical anticholinergic formulations.
> Sourcing & Supply
TCS Industries Limited supports development, qualification and commercial purchasing discussions for Diphemanil Methylsulfate with buyers in Australia, New Zealand, Canada and South Korea.
- Evaluation and commercial quantities: 100 g samples for analytical work; 1 kg for formulation development; 5–25 kg for production. Custom synthesis available for pharmaceutical-grade material.
- Pallet quantities and production campaigns: repeat supply is coordinated against packaging, lead time, annual demand and destination-market import requirements.
> Quality & Documentation
Key specification parameters include assay (≥98.0%), related substances, loss on drying, residue on ignition, heavy metals, residual solvents, and microbial limits. White to off-white crystalline powder. Soluble in water and ethanol. Identity by HPLC, IR, and melting point. Meets in-house pharmaceutical specifications. COA and MSDS are standard.
> Packaging
Diphemanil methylsulfate is a white to off-white crystalline powder. Standard packaging includes glass bottles or PE-lined aluminium foil bags in fibre drums. Store at controlled room temperature (15–25 °C). Protect from moisture. Shelf life depends on storage conditions and is specified on COA. Labels and documents are checked before dispatch.
> Pricing & MOQ
Pricing is quoted by specification, packaging and destination. Common commercial discussions use 25 kg bag/drum formats, pallet quantities and production-campaign planning; smaller samples may be reviewed for qualified formulation teams.
> Regulatory & Compounding Context
Diphemanil methylsulfate (Prantal) was previously FDA-approved as an oral anticholinergic. The original NDA is discontinued in the US market. It remains available in some markets for dermatological and GI indications. New formulations may require full NDA or equivalent dossier. No current pharmacopoeial monograph in USP or Ph.Eur.
> Alias Index
- INN: Diphemanil
- CAS Number: 62-97-5
- Formula: C₂₁H₂₅NO₄S (MW 389.49)
- Brand name: Prantal (discontinued in US)
- Pharmacological class: Quaternary ammonium anticholinergic
- Commercial request terms: diphemanil methylsulfate API, anticholinergic API, Prantal generic, hyperhidrosis API, TCS Industries Limited
> FAQ
Why is Diphemanil a quaternary ammonium compound?
The quaternary ammonium structure makes diphemanil permanently charged and unable to cross the blood-brain barrier. This eliminates central anticholinergic side effects (confusion, sedation) while retaining peripheral activity on sweat glands and GI smooth muscle. This is a key advantage over tertiary amine anticholinergics like atropine.
What documents are available for Diphemanil Methylsulfate orders?
COA and MSDS are standard for commercial discussions. COO, packing list, invoice and other import-support documents can be arranged according to order scope.
Do you supply Diphemanil Methylsulfate to Australia and Canada?
Yes. We support B2B buyers in Australia, New Zealand, Canada and South Korea, subject to route and document review.
Do you supply New Zealand and South Korea?
Yes. We review Australia, New Zealand, Canada and South Korea for project supply, import documents, packaging and logistics planning before quotation.
Is Diphemanil still used clinically?
Diphemanil is used in limited markets, primarily for topical hyperhidrosis management. Its oral GI antispasmodic use has been largely replaced by newer agents. It remains of interest for topical anticholinergic formulations where a water-soluble quaternary compound is needed.
What formulations are possible?
Diphemanil methylsulfate is water-soluble, enabling aqueous solution, cream, and gel formulations for topical use. Oral tablets (100 mg historically) are manufactured by direct compression or wet granulation. Topical formulations at 2–5% in cream or gel base are reported in literature for focal hyperhidrosis.
Can you arrange samples before commercial purchasing?
Samples or evaluation quantities may be reviewed for qualified buyers after target specification, application and destination-market requirements are clarified.
How is Diphemanil Methylsulfate packaged for export?
Packaging is confirmed by quantity and material properties. Typical options include foil bags, HDPE containers, fibre drums, 25 kg bags or palletized export packaging.
Can buyer-defined specifications be reviewed?
Yes. Send the specification, methods, impurity limits and required documents. TCS can review feasibility before confirming quotation and lead time.
What payment terms are normally used?
Standard payment is 100% T/T before dispatch unless a different arrangement has been approved for an established commercial account.
What lead time should buyers expect?
Lead time depends on stock, batch size, document scope and destination. Available stock can move faster; made-to-order or pallet programs require longer planning.
Is custom synthesis available?
Yes. Since commercial bulk production has decreased, TCS can arrange custom synthesis of diphemanil methylsulfate from qualified manufacturers. Quantities from gram-scale for R&D to multi-kilogram for clinical supply. Synthesis follows established routes with full analytical characterization and regulatory documentation.
Last reviewed: June 2026
Evaluation and research orders (≤10 kg) are shipped with COA, MSDS, and certificate of origin. Bulk commercial orders (>10 kg) qualify for volume pricing with a full technical documentation package available on request.
> Request a Quote
If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.