TCS Industries Limited (China-sourced API supplier) supplies Denatonium Bromide CAS 56-94-0 for pharmaceutical B2B procurement — COA, MSDS, and technical documentation available on request.
> Overview
| Product Name | Denatonium Bromide |
|---|---|
| Structural Formula |  |
| CAS Number | 56-94-0 |
| Molecular Formula | C₃₂H₅₂Br₂N₄O₄ |
| Molecular Weight | 716.6 g/mol |
| InChIKey | YHKBUDZECQDYBR-UHFFFAOYSA-L |
| SMILES | Available on request where applicable |
| Appearance | White crystalline powder |
| Purity / Grade | By agreed specification and batch COA |
| Storage | Room temperature, dry conditions |
Denatonium Bromide (CAS 3734-33-6, also known as Bitrex) is the most bitter compound known, with a detection threshold of approximately 10 ppb in water. It has the formula C₂₈H₃₄BrNO₃ (MW 464.44) and is a quaternary ammonium salt of lidocaine with a benzoyl group. Denatonium bromide is used as an aversive (bittering) agent to prevent accidental ingestion of toxic household products, industrial chemicals, and denatured alcohol.
TCS Industries Limited, a Hong Kong-based trading and sourcing company, supplies Denatonium Bromide in pharmaceutical and technical grades for global procurement programs.
> Applications
Aversive bittering agent for poison prevention
Denatonium bromide at 10–50 ppm is added to toxic household products (antifreeze, cleaning agents, nail polish remover), denatured alcohol, and industrial chemicals to deter accidental ingestion by children and animals. Its extreme bitterness triggers an immediate aversive response. Sibert et al. (Arch Dis Child, 1996, 74:521–524) evaluated the effectiveness of denatonium bromide as an aversive agent in reducing childhood poisoning from household products.
Pharmaceutical and animal repellent applications
In pharmaceuticals, denatonium bromide is added to external-use products (rubbing alcohol, topical antiseptics) to prevent oral misuse. It is also used as an animal repellent coating on cables, garbage bags, and crops. In nail-biting deterrents, it is the active bitter agent at low concentration.
> Sourcing & Supply
TCS Industries Limited supports development, qualification and commercial purchasing discussions for Denatonium Bromide with buyers in South America, Europe, the United Kingdom, Australia, New Zealand, Mexico and Canada.
- Evaluation and commercial quantities: 100 g and 1 kg samples for formulation trials; 5 kg and 25 kg containers for production. Bromide and benzoate salt forms available. Anhydrous and solution (in propylene glycol) forms offered.
- Pallet quantities and production campaigns: repeat supply is coordinated against packaging, lead time, annual demand and destination-market import requirements.
> Quality & Documentation
Key specification parameters include assay (≥99.0% C₂₈H₃₄BrNO₃ on anhydrous basis), loss on drying (≤0.5%), residue on ignition (≤0.1%), melting point (163–170 °C), heavy metals (Pb ≤10 ppm), and identification by IR and bromide test. White crystalline powder, odorless, extremely bitter taste. Freely soluble in water and ethanol. Meets EP (Denatonii benzoas, benzoate form) and internal pharmaceutical specifications. COA and MSDS are standard.
> Packaging
Denatonium bromide is a white crystalline powder. Extremely bitter — handle with gloves to avoid taste contamination. Standard packaging includes 1 kg or 5 kg bottles in secondary containers, 25 kg fibre drums with PE liner. Store at room temperature in tightly sealed containers. Shelf life is typically 48 months. Labels and documents are checked before dispatch.
> Pricing & MOQ
Pricing is quoted by specification, packaging and destination. Common commercial discussions use 25 kg bag/drum formats, pallet quantities and production-campaign planning; smaller samples may be reviewed for qualified formulation teams.
> Regulatory & Compounding Context
Denatonium bromide is listed as a denaturant in alcohol regulations worldwide (US TTB, EU). Required by regulation in antifreeze in many US states and EU member states. Listed in the FDA IID as a flavoring/masking agent. Ph.Eur. monographs the benzoate salt (Denatonii benzoas). No scheduled substance restrictions. Oregon and other US states mandate denatonium in antifreeze products by law.
> Alias Index
- IUPAC: Benzyl[2-(2,6-dimethylanilino)-2-oxoethyl]diethylammonium bromide
- CAS Number: 3734-33-6 (bromide); 3734-33-6 (sometimes listed as benzoate: 40316-09-8)
- Formula: C₂₈H₃₄BrNO₃ (MW 464.44)
- Trade name: Bitrex (registered trademark of Johnson Matthey)
- Related salt: Denatonium benzoate (CAS 40316-09-8)
- Commercial request terms: denatonium bromide, Bitrex equivalent, bittering agent, aversive denaturant, denatured alcohol additive, TCS Industries Limited
> FAQ
How bitter is Denatonium Bromide?
Denatonium bromide is detected by taste at approximately 10 ppb (parts per billion) in water. It is 1000 times more bitter than quinine. A concentration of 10 ppm is sufficient to make any liquid intensely unpleasant. This extreme bitterness at nanogram levels makes it effective at very low concentrations that do not affect product performance.
What documents are available for Denatonium Bromide orders?
COA and MSDS are standard for commercial discussions. COO, packing list, invoice and other import-support documents can be arranged according to order scope.
Can TCS Industries Limited support Denatonium Bromide supply to South America?
Yes. We support B2B buyers in Argentina, Colombia, Chile, Peru, Ecuador, Uruguay, Bolivia, Brazil, Paraguay, Venezuela, Guyana and Suriname, subject to route and document review.
Do you support Europe, the United Kingdom, Australia, New Zealand, Mexico and Canada?
Yes. These destinations can be reviewed for project supply, import documents, packaging and logistics planning before quotation.
Is Denatonium Bromide toxic?
No. Denatonium bromide has very low toxicity (oral LD50 >500 mg/kg in rats). At the concentrations used as a bittering agent (10–50 ppm), it is far below any toxic threshold. Its safety at aversive concentrations is the basis for regulatory mandates — it deters ingestion without adding toxicity to the product it protects.
What is the difference between the Bromide and Benzoate salts?
Denatonium bromide (CAS 3734-33-6) and denatonium benzoate (CAS 40316-09-8) have the same denatonium cation and identical bitterness. The bromide salt is more common in industrial use. The benzoate salt has a Ph.Eur. monograph and is preferred in pharmaceutical applications. Both are freely soluble in water and ethanol.
Can you arrange samples before commercial purchasing?
Samples or evaluation quantities may be reviewed for qualified buyers after target specification, application and destination-market requirements are clarified.
How is Denatonium Bromide packaged for export?
Packaging is confirmed by quantity and material properties. Typical options include foil bags, HDPE containers, fibre drums, 25 kg bags or palletized export packaging.
Can buyer-defined specifications be reviewed?
Yes. Send the specification, methods, impurity limits and required documents. TCS can review feasibility before confirming quotation and lead time.
What payment terms are normally used?
Standard payment is 100% T/T before dispatch unless a different arrangement has been approved for an established commercial account.
What lead time should buyers expect?
Lead time depends on stock, batch size, document scope and destination. Available stock can move faster; made-to-order or pallet programs require longer planning.
Is Denatonium required by law in antifreeze?
Yes, in many jurisdictions. Oregon (US) was the first state to mandate denatonium in antifreeze (2005). Multiple US states and EU member states have similar requirements. Typical mandated concentration is 30–50 ppm denatonium benzoate. These laws aim to prevent accidental poisoning of children and pets by ethylene glycol-based antifreeze.
Last reviewed: June 2026
Evaluation and research orders (≤10 kg) are shipped with COA, MSDS, and certificate of origin. Bulk commercial orders (>10 kg) qualify for volume pricing with a full technical documentation package available on request.
> Request a Quote
If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.