Croscarmellose Sodium: Superdisintegrant for Immediate-Release Tablets
Croscarmellose sodium (cross-linked sodium carboxymethylcellulose) is a superdisintegrant that rapidly absorbs water and swells to promote fast tablet disintegration. It is one of the three most widely used superdisintegrants alongside crospovidone and sodium starch glycolate, and is effective at low concentrations in both direct compression and wet granulation processes.
Product Profile
| CAS Number | 74811-65-7 |
|---|---|
| Appearance | White to off-white, free-flowing powder |
| Function | Superdisintegrant |
| Typical Use Level | 1–5% w/w (commonly 2–3%) |
| Compendial Grade | EP / USP-NF / JP |
Formulation Applications
Croscarmellose sodium acts primarily by wicking and swelling — it draws water into the tablet matrix by capillary action and then swells to disrupt the tablet structure. It is effective both intragranularly (added before granulation) and extragranularly (added to the final blend), and many formulators split the total amount between both positions for optimal disintegration. Unlike sodium starch glycolate, croscarmellose sodium does not form a viscous gel, which makes it particularly suitable for formulations where rapid drug release is critical. It is compatible with most APIs and excipients, though its performance can be reduced in highly hydrophobic formulations unless wetting agents are included.
Why Source from TCS
TCS supplies croscarmellose sodium in pharmaceutical grade to formulators across Europe. Available in standard packaging with flexible quantities for R&D through production scale. Contact us with your application and volume requirements.
FAQ
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