TCS Industries Limited (China-sourced API supplier) supplies Unifiram — API CAS 272786-64-8 for pharmaceutical B2B procurement — COA, MSDS, and technical documentation available on request.
> Overview
| Product Name | Unifiram |
|---|---|
| Structural Formula |  |
| CAS Number | 272786-64-8 |
| Molecular Formula | C₁₃H₁₅FN₂O₃S |
| Molecular Weight | 298.34 g/mol |
| InChIKey | SNRTZFZAFBIBJP-UHFFFAOYSA-N |
| SMILES | Available on request where applicable |
| Appearance | White crystalline powder |
| Purity / Grade | By agreed specification and batch COA |
| Storage | Room temperature, dry conditions |
Unifiram (CAS 272786-64-8, development code DM-235) is an experimental nootropic compound with the formula C₁₃H₁₅NO₃ (MW 233.26). It is a piperazine-derived ampakine that positively modulates AMPA-type glutamate receptors. Unifiram has shown cognitive enhancement in animal models at doses 100–1000× lower than piracetam. It has not been approved for clinical use in any jurisdiction and remains a research chemical.
TCS Industries Limited, a Hong Kong-based trading and sourcing company, supplies Unifiram as a research-grade API for preclinical research and development programs.
> Applications
AMPA receptor modulation and cognition research
Unifiram enhances long-term potentiation (LTP) and improves memory performance in passive avoidance and Morris water maze tests in rodents. It acts as a positive allosteric modulator of AMPA receptors, increasing glutamatergic neurotransmission without direct receptor activation. Galeotti et al. (Behav Brain Res, 2003, 141:11–17) demonstrated the anti-amnesic properties of unifiram in mouse models and reported potency exceeding piracetam by several orders of magnitude in cognitive enhancement assays.
Research applications
Unifiram is used in academic research on glutamatergic synaptic plasticity, AMPA receptor pharmacology, and cognitive enhancement mechanisms. It is not an approved drug, has no completed clinical trials, and is classified as a research chemical. It has gained attention in the nootropic research community due to its high potency.
> Sourcing & Supply
TCS Industries Limited supports development, qualification and commercial purchasing discussions for Unifiram with buyers in Australia, New Zealand, Canada and South Korea.
- Evaluation and commercial quantities: 10 g samples for screening assays; 100 g and 1 kg for research programs. Research-grade crystalline powder with full analytical characterization. For research use only — not for human consumption.
- Pallet quantities and production campaigns: repeat supply is coordinated against packaging, lead time, annual demand and destination-market import requirements.
> Quality & Documentation
Key specification parameters include assay (≥98.0%), related substances, loss on drying, heavy metals, residual solvents, and microbial limits. White crystalline powder. Soluble in DMSO, slightly soluble in water. Identity by HPLC, NMR, and MS. Research grade — no pharmacopeial monograph exists. COA with full analytical data is standard.
> Packaging
Unifiram is a white crystalline powder. Standard packaging includes sealed amber glass vials or foil bags under nitrogen (1 g, 10 g, 50 g, or 100 g). Store at -20 °C or 2–8 °C. Protect from light and moisture. Labeled for research use only. Labels and documents are checked before dispatch.
> Pricing & MOQ
Pricing is quoted by specification, packaging and destination. Common commercial discussions use 25 kg bag/drum formats, pallet quantities and production-campaign planning; smaller samples may be reviewed for qualified formulation teams.
> Regulatory & Compounding Context
Unifiram is not approved for human use in any jurisdiction. No pharmacopeial monograph exists. It is classified as a research chemical. Not scheduled as a controlled substance in most jurisdictions but may be subject to novel substance or analog regulations. Buyers are responsible for verifying regulatory status in their jurisdiction. For research use only.
> Alias Index
- Name: Unifiram
- CAS Number: 272786-64-8
- Development code: DM-235
- Formula: C₁₃H₁₅NO₃ (MW 233.26)
- Pharmacological class: AMPA receptor positive allosteric modulator (ampakine)
- Status: Research chemical, not approved for clinical use
- Commercial request terms: unifiram research chemical, DM-235, AMPA modulator, nootropic research API, TCS Industries Limited
> FAQ
Is Unifiram approved for human use?
No. Unifiram has not completed clinical trials and is not approved by any regulatory agency (FDA, EMA, or other). It is an experimental compound studied in preclinical (animal) models only. It is supplied for research use only and is not intended for human consumption.
What documents are available for Unifiram orders?
COA and MSDS are standard for commercial discussions. COO, packing list, invoice and other import-support documents can be arranged according to order scope.
Do you supply Unifiram to Australia and Canada?
Yes. We support B2B buyers in Australia, New Zealand, Canada and South Korea, subject to route and document review.
Do you supply New Zealand and South Korea?
Yes. We review Australia, New Zealand, Canada and South Korea for project supply, import documents, packaging and logistics planning before quotation.
How does Unifiram compare to Piracetam?
In rodent models, unifiram shows anti-amnesic activity at doses 100–1000× lower than piracetam (0.01–0.1 mg/kg vs. 30–100 mg/kg). Both modulate AMPA receptor function, but unifiram has higher binding affinity. However, piracetam has decades of clinical data and pharmacopeial monographs, while unifiram has only preclinical data with no established human safety profile.
What is an ampakine?
Ampakines are compounds that positively modulate AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors — ionotropic glutamate receptors critical for synaptic plasticity and memory formation. Ampakines slow AMPA receptor desensitization and deactivation, enhancing excitatory neurotransmission. Several ampakine classes (benzamides, benzothiadiazines, piperazines) have been studied for cognitive disorders.
Can you arrange samples before commercial purchasing?
Samples or evaluation quantities may be reviewed for qualified buyers after target specification, application and destination-market requirements are clarified.
How is Unifiram packaged for export?
Packaging is confirmed by quantity and material properties. Typical options include foil bags, HDPE containers, fibre drums, 25 kg bags or palletized export packaging.
Can buyer-defined specifications be reviewed?
Yes. Send the specification, methods, impurity limits and required documents. TCS can review feasibility before confirming quotation and lead time.
What payment terms are normally used?
Standard payment is 100% T/T before dispatch unless a different arrangement has been approved for an established commercial account.
What lead time should buyers expect?
Lead time depends on stock, batch size, document scope and destination. Available stock can move faster; made-to-order or pallet programs require longer planning.
Is regulatory documentation available?
Unifiram is supplied with a full analytical COA including HPLC purity, NMR identity, mass spectrometry confirmation, and residual solvent analysis. No DMF or pharmacopeial monograph exists. Buyers should verify regulatory classification in their jurisdiction before ordering. For research use only.
Last reviewed: June 2026
Evaluation and research orders (≤10 kg) are shipped with COA, MSDS, and certificate of origin. Bulk commercial orders (>10 kg) qualify for volume pricing with a full technical documentation package available on request.
> Request a Quote
If your team already has a target application, estimated quantity, destination market, or documentation requirements, send those details so the commercial response can be prepared more efficiently.